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Journal of Biopharmaceutical Statistics Volume 22, 2012 - Issue 4: Adaptive Designs for Clinical Trials: Considerations about and Beyond the FDA Adaptive Designs Guidance
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Original Articles

Minimizing the Maximum Expected Sample Size in Two-Stage Phase II Clinical Trials with Continuous Outcomes

James M. S. Wason MRC Biostatistics Unit Hub for Trials Methodology Research, Cambridge, United KingdomCorrespondence[email protected]
&
Adrian P. Mander MRC Biostatistics Unit Hub for Trials Methodology Research, Cambridge, United Kingdom
Pages 836-852 | Received 06 Apr 2010, Accepted 10 Sep 2010, Published online: 31 May 2012

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