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Drug Delivery Volume 25, 2018 - Issue 1
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Research Article

Bone-targeted methotrexate–alendronate conjugate inhibits osteoclastogenesis in vitro and prevents bone loss and inflammation of collagen-induced arthritis in vivo

Zi’ang XieDepartment of Orthopaedics, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, China; ;Key Laboratory of Biotherapy of Zhejiang Province, Hangzhou, China; View further author information
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Guanxiong LiuSchool of Chemistry and Chemical Engineering, Yangzhou University, Jiangsu, China; View further author information
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Pan TangDepartment of Orthopaedics, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, China; ;Key Laboratory of Biotherapy of Zhejiang Province, Hangzhou, China; View further author information
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Xuewu SunDepartment of Orthopaedics, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, China; ;Key Laboratory of Biotherapy of Zhejiang Province, Hangzhou, China; View further author information
,
Shuai ChenDepartment of Orthopaedics, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, China; View further author information
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An QinDepartment of Orthopaedics, Shanghai Key Laboratory of Orthopaedic Implant, Shanghai Ninth People’s Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, PR ChinaView further author information
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Peizhi ZhuSchool of Chemistry and Chemical Engineering, Yangzhou University, Jiangsu, China; Correspondence[email protected]
View further author information
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Jianfeng ZhangDepartment of Orthopaedics, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, China; Correspondence[email protected]
View further author information
&
Shunwu FanDepartment of Orthopaedics, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, China; Correspondence[email protected]
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Pages 187-197 | Received 23 Sep 2017, Accepted 25 Dec 2017, Published online: 05 Jan 2018

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