In vivo nose-to-brain delivery of the hydrophilic antiviral ribavirin by microparticle agglomerates

Alessandro GiulianiDepartment of Veterinary Medical Science, Alma Mater Studiorum – University of Bologna, Ozzano, Italy;

Anna Giulia BalducciDepartment of Food and Drug, University of Parma, Parma, Italy; ;Interdepartmental Center for Health Products – Biopharmanet TEC, University of Parma, Parma, Italy;

Elisa ZironiDepartment of Veterinary Medical Science, Alma Mater Studiorum – University of Bologna, Ozzano, Italy;

Gaia ColomboDepartment of Life Sciences and Biotechnology, University of Ferrara, Ferrara, Italy;

Fabrizio BortolottiDepartment of Life Sciences and Biotechnology, University of Ferrara, Ferrara, Italy;

Luca LorenziniIRET Foundation, Ozzano, (BO), Italy;

Viola GalligioniDepartment of Veterinary Medical Science, Alma Mater Studiorum – University of Bologna, Ozzano, Italy;

Giampiero PagliucaDepartment of Veterinary Medical Science, Alma Mater Studiorum – University of Bologna, Ozzano, Italy;

Alessandra ScagliariniDepartment of Veterinary Medical Science, Alma Mater Studiorum – University of Bologna, Ozzano, Italy;

Laura CalzàIRET Foundation, Ozzano, (BO), Italy; ;Department of Pharmacy and Biotechnology, Ozzano, Italy

Fabio SonvicoDepartment of Food and Drug, University of Parma, Parma, Italy; ;Interdepartmental Center for Health Products – Biopharmanet TEC, University of Parma, Parma, Italy; Correspondence[email protected]

http://orcid.org/0000-0001-7372-1456