Zinc oxide nanoparticles and spironolactone-enhanced Nrf2/HO-1 pathway and inhibited Wnt/β-catenin pathway in adenine-induced nephrotoxicity in rats

Amira Awadallaa Center of Excellence for Genome and Cancer Research, Urology and Nephrology Center, Mansoura University, Mansoura, Egypt

Eman T. Hamama Center of Excellence for Genome and Cancer Research, Urology and Nephrology Center, Mansoura University, Mansoura, Egypt

Fardous F. El-Sendunyb Chemistry Department, Faculty of Science, Mansoura University, Mansoura, Egypt;c Department of Pathology & Laboratory Medicine, Sylvester Comprehensive Cancer Center, Miami, FL, USA

Nisreen Mansour Omard Department of Medical Physiology, Faculty of Medicine, Mansoura University, Mansoura, Egypt

Mohamed R. Mahdie Department of Human Anatomy and Embryology, Faculty of Medicine, Mansoura University, Mansoura, Egypt

Nashwa Barakatf Urology and Nephrology Center, Mansoura University, Mansoura, Egypt

Omar A. Ammarg Basic Science Department, Delta University for Science and Technology, Gamasa, Egypt

Abdelaziz M. Husseind Department of Medical Physiology, Faculty of Medicine, Mansoura University, Mansoura, Egypt

Ahmed A. Shokeira Center of Excellence for Genome and Cancer Research, Urology and Nephrology Center, Mansoura University, Mansoura, Egypt;f Urology and Nephrology Center, Mansoura University, Mansoura, Egypt

Salma M. Khirallahh Biochemistry Division, Chemistry Department, Faculty of Science, Port Said University, Port Said, EgyptCorrespondence[email protected]

https://orcid.org/0000-0002-7631-6840