Anti-cancer and immunomodulatory evaluation of new nicotinamide derivatives as potential VEGFR-2 inhibitors and apoptosis inducers: in vitro and in silico studies

Reda G. Yousefa Pharmaceutical Medicinal Chemistry & Drug Design Department, Faculty of Pharmacy (Boys), Al-Azhar University, Cairo, EgyptView further author information

Alaa Elwana Pharmaceutical Medicinal Chemistry & Drug Design Department, Faculty of Pharmacy (Boys), Al-Azhar University, Cairo, EgyptView further author information

Ibraheem M. M. Gobaarab Zoology Department, Faculty of Science (Boys), Al-Azhar University, Cairo, EgyptView further author information

Ahmed B. M. Mehanyb Zoology Department, Faculty of Science (Boys), Al-Azhar University, Cairo, EgyptView further author information

Wagdy M. Eldehnac Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Kafrelsheikh University, Kafrelsheikh, EgyptView further author information

Souad A. El-Metwallyd Department of Basic Science, Higher Technological institute, 10th of Ramadan City, EgyptView further author information

Bshra A. Alsfouke Department of Pharmaceutical Sciences, College of Pharmacy, Princess Nourah Bint Abdulrahman University, Riyadh, Saudi ArabiaView further author information

Eslam B. Elkaeedf Department of Pharmaceutical Sciences, College of Pharmacy, AlMaarefa University, Riyadh, Saudi ArabiaView further author information

Ahmed M. Metwalyg Pharmacognosy and Medicinal Plants Department, Faculty of Pharmacy (Boys), Al-Azhar University, Cairo, Egypt;h Biopharmaceutical Products Research Department, Genetic Engineering and Biotechnology Research Institute, City of Scientific Research and Technological Applications (SRTA-City), Alexandria, EgyptCorrespondence[email protected]
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Ibrahim H. Eissaa Pharmaceutical Medicinal Chemistry & Drug Design Department, Faculty of Pharmacy (Boys), Al-Azhar University, Cairo, EgyptCorrespondence[email protected]