New 1,2,3-triazole/1,2,4-triazole hybrids linked to oxime moiety as nitric oxide donor selective COX-2, aromatase, B-RAF^V600E and EGFR inhibitors celecoxib analogs: design, synthesis, anti-inflammatory/anti-proliferative activities, apoptosis and molecular modeling study

Wael A. A. Fadalya Pharmaceutical Organic Chemistry Department, Faculty of Pharmacy, Beni-Suef University, Beni-Suef, EgyptView further author information

Mohamed T. M. Nemrb Pharmaceutical Organic Chemistry Department, Faculty of Pharmacy, Cairo University, Cairo, EgyptCorrespondence[email protected]
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Taha H. Zidana Pharmaceutical Organic Chemistry Department, Faculty of Pharmacy, Beni-Suef University, Beni-Suef, EgyptView further author information

Fatma E. A. Mohameda Pharmaceutical Organic Chemistry Department, Faculty of Pharmacy, Beni-Suef University, Beni-Suef, EgyptView further author information

Marwa M. Abdelhakeema Pharmaceutical Organic Chemistry Department, Faculty of Pharmacy, Beni-Suef University, Beni-Suef, EgyptView further author information

Nour N. Abu Jayabc Sharjah Institute for Medical Research, College of Medicine, University of Sharjah, Sharjah, United Arab EmiratesView further author information

Hany A. Omarc Sharjah Institute for Medical Research, College of Medicine, University of Sharjah, Sharjah, United Arab Emirates;d Pharmacology Department, Faculty of Pharmacy, Beni-Suef University, Beni-Suef, EgyptView further author information

Khaled R. A. Abdellatifa Pharmaceutical Organic Chemistry Department, Faculty of Pharmacy, Beni-Suef University, Beni-Suef, Egypt;e Pharmaceutical Sciences Department, Ibn Sina National College for Medical Studies, Jeddah, Saudi ArabiaView further author information

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New 1,2,3-triazole/1,2,4-triazole hybrids linked to oxime moiety as nitric oxide donor selective COX-2, aromatase, B-RAF^V600E and EGFR inhibitors celecoxib analogs: design, synthesis, anti-inflammatory/anti-proliferative activities, apoptosis and molecular modeling study

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New 1,2,3-triazole/1,2,4-triazole hybrids linked to oxime moiety as nitric oxide donor selective COX-2, aromatase, B-RAFV600E and EGFR inhibitors celecoxib analogs: design, synthesis, anti-inflammatory/anti-proliferative activities, apoptosis and molecular modeling study

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New 1,2,3-triazole/1,2,4-triazole hybrids linked to oxime moiety as nitric oxide donor selective COX-2, aromatase, B-RAF^V600E and EGFR inhibitors celecoxib analogs: design, synthesis, anti-inflammatory/anti-proliferative activities, apoptosis and molecular modeling study