Can a serum acetaminophen concentration obtained less than 4 hours post-ingestion determine which patients do not require treatment with acetylcysteine?^*

Mark C. YaremaPoison and Drug Information Service, Alberta Health Services, Alberta, Canada; ;Department of Emergency Medicine, University of Calgary, Alberta, Canada; ;Section of Clinical Pharmacology and Toxicology, Alberta Health Services, Alberta, Canada; Correspondence[email protected]

Jason P. GreenDepartment of Pediatrics, McMaster University, Ontario, Canada;

Marco L. A. SivilottiDepartment of Emergency Medicine, Queen’s University, Ontario, Canada; ;Department of Biomedical & Molecular Sciences, Queen’s University, Ontario, Canada;

David W. JohnsonPoison and Drug Information Service, Alberta Health Services, Alberta, Canada; ;Department of Pediatrics, University of Calgary, Alberta, Canada;

Alberto Nettel-AguirreDepartment of Pediatrics, University of Calgary, Alberta, Canada; ;Alberta Children’s Hospital Research Institute for Child & Maternal Health, Alberta, Canada; ;Department of Community Health Sciences, University of Calgary, Alberta, Canada;

Charlemaigne VictorinoPrairie Regional Research Data Centre, Statistics Canada, Alberta, Canada;

Daniel A. SpykerDepartment of Emergency Medicine, Oregon Health Sciences University, Portland, OR, USA;

Barry H. RumackDepartment of Pediatrics, University of Colorado School of Medicine, Denver, CO, USA

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Can a serum acetaminophen concentration obtained less than 4 hours post-ingestion determine which patients do not require treatment with acetylcysteine?^*

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Can a serum acetaminophen concentration obtained less than 4 hours post-ingestion determine which patients do not require treatment with acetylcysteine?*

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Can a serum acetaminophen concentration obtained less than 4 hours post-ingestion determine which patients do not require treatment with acetylcysteine?^*