Modest and variable efficacy of pre-exposure hydroxocobalamin and dicobalt edetate in a porcine model of acute cyanide salt poisoning

Adrian ThompsonDepartment of Pharmacology, Toxicology, & Therapeutics, University/BHF Centre for Cardiovascular Science, University of Edinburgh, Edinburgh, UK; View further author information

Michael DunnMedical Toxicology Centre, University of Newcastle, Newcastle upon Tyne, UK; View further author information

Robert D JeffersonMedical Toxicology Centre, University of Newcastle, Newcastle upon Tyne, UK; View further author information

Kosala DissanayakeDepartment of Pharmacology, Toxicology, & Therapeutics, University/BHF Centre for Cardiovascular Science, University of Edinburgh, Edinburgh, UK; View further author information

Frances ReedWellcome Critical Care Laboratory for Large Animals, Roslin Institute, Royal (Dick) School of Veterinary Studies, University of Edinburgh, Edinburgh, UKView further author information

Rachael GregsonWellcome Critical Care Laboratory for Large Animals, Roslin Institute, Royal (Dick) School of Veterinary Studies, University of Edinburgh, Edinburgh, UKView further author information

Stephen GreenhalghWellcome Critical Care Laboratory for Large Animals, Roslin Institute, Royal (Dick) School of Veterinary Studies, University of Edinburgh, Edinburgh, UKView further author information

R Eddie CluttonWellcome Critical Care Laboratory for Large Animals, Roslin Institute, Royal (Dick) School of Veterinary Studies, University of Edinburgh, Edinburgh, UKView further author information

Peter G BlainMedical Toxicology Centre, University of Newcastle, Newcastle upon Tyne, UK; View further author information

Simon HL ThomasMedical Toxicology Centre, University of Newcastle, Newcastle upon Tyne, UK; View further author information

Michael EddlestonDepartment of Pharmacology, Toxicology, & Therapeutics, University/BHF Centre for Cardiovascular Science, University of Edinburgh, Edinburgh, UK; Correspondence[email protected]