Establishing in vitro in vivo correlations to screen monoclonal antibodies for physicochemical properties related to favorable human pharmacokinetics

Lindsay B. AveryBioMedicine Design, Pfizer Inc., Andover, MA, USA

Jason WadeBioMedicine Design, Pfizer Inc., Cambridge, MA, USA

Mengmeng WangBioMedicine Design, Pfizer Inc., Andover, MA, USA

Amy TamBioMedicine Design, Pfizer Inc., Cambridge, MA, USA

Amy KingBioMedicine Design, Pfizer Inc., Cambridge, MA, USA

Nicole Piche-NicholasBioMedicine Design, Pfizer Inc., Cambridge, MA, USA

Mania S. KavosiBioMedicine Design, Pfizer Inc., Andover, MA, USA

Steve PennBioMedicine Design, Pfizer Inc., Andover, MA, USA;Medicine Design, Pfizer Inc., Cambridge, MA, USA

David CirelliPharmaceutical Sciences, Pfizer Inc., Andover, MA, USA

Jeffrey C. KurzBioMedicine Design, Pfizer Inc., Andover, MA, USA

Minlei ZhangBioMedicine Design, Pfizer Inc., Andover, MA, USA

Orla CunninghamBiomedicine Design, Pfizer Inc., Dublin, Ireland

Rhys JonesBioMedicine Design, Pfizer Inc., Cambridge, MA, USA;Currently Medicine Design, Pfizer Inc., La Jolla, CA, USA

Brian J. FennellBiomedicine Design, Pfizer Inc., Dublin, Ireland

Barry McDonnellBiomedicine Design, Pfizer Inc., Dublin, Ireland

Paul SakorafasPharmaceutical Sciences, Pfizer Inc., Andover, MA, USA

James ApgarBioMedicine Design, Pfizer Inc., Cambridge, MA, USA

William J. FinlayBiomedicine Design, Pfizer Inc., Dublin, Ireland;Currently CodeBase, Edinburgh, UK

Laura LinBioMedicine Design, Pfizer Inc., Cambridge, MA, USA

Laird BloomBioMedicine Design, Pfizer Inc., Cambridge, MA, USACorrespondence[email protected]

Denise M. O'HaraBioMedicine Design, Pfizer Inc., Andover, MA, USACorrespondencedenise.o'[email protected]

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