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Nonclinical immunogenicity risk assessment for knobs-into-holes bispecific IgG1 antibodies
Wen-Ting K. Tsaia Department of Antibody Engineering, Genentech, Inc, South San Francisco, CA, USACorrespondence[email protected]
https://orcid.org/0000-0003-4800-8848View further author information
Yinyin Lib Department of Biochemical and Cellular Pharmacology, Genentech, Inc, South San Francisco, CA, USA
https://orcid.org/0000-0001-6195-8309View further author information
Zhaojun Yinc Department of Bioanalytical Sciences, Genentech, Inc, South San Francisco, CA, USAView further author information
, Peter Tranc Department of Bioanalytical Sciences, Genentech, Inc, South San Francisco, CA, USAView further author information
, Qui Phungd Department of Microchemistry, Proteomics and Lipidomics, Genentech, Inc, South San Francisco, CA, USA
https://orcid.org/0000-0001-6472-4567View further author information
Zhenru Zhoud Department of Microchemistry, Proteomics and Lipidomics, Genentech, Inc, South San Francisco, CA, USAView further author information
, Kun Pengc Department of Bioanalytical Sciences, Genentech, Inc, South San Francisco, CA, USA
https://orcid.org/0000-0002-0480-073XView further author information
Dan Qinb Department of Biochemical and Cellular Pharmacology, Genentech, Inc, South San Francisco, CA, USAView further author information
, Sien Tamb Department of Biochemical and Cellular Pharmacology, Genentech, Inc, South San Francisco, CA, USAView further author information
, Christoph Spiessa Department of Antibody Engineering, Genentech, Inc, South San Francisco, CA, USA
https://orcid.org/0000-0002-0570-9700View further author information
Jochen Brumme Department of Nonclinical Biostatistics, Genentech, Inc, South San Francisco, CA, USA
https://orcid.org/0000-0001-9518-038XView further author information
Manda Wongf Department of Structural Biology, Genentech, Inc, South San Francisco, CA, USA
https://orcid.org/0000-0001-5830-1517View further author information
Zhengmao Yeb Department of Biochemical and Cellular Pharmacology, Genentech, Inc, South San Francisco, CA, USAView further author information
, Patrick Wuc Department of Bioanalytical Sciences, Genentech, Inc, South San Francisco, CA, USA
https://orcid.org/0000-0002-1437-6688View further author information
Sivan Cohenc Department of Bioanalytical Sciences, Genentech, Inc, South San Francisco, CA, USA
https://orcid.org/0000-0001-6213-6200View further author information
Paul J. Cartera Department of Antibody Engineering, Genentech, Inc, South San Francisco, CA, USACorrespondence[email protected]
https://orcid.org/0000-0001-7854-062XView further author information
Article: 2362789
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Received 15 Feb 2024, Accepted 29 May 2024, Published online: 06 Jun 2024
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