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Research Paper
Gaussian curvature dilutes the nuclear lamina, favoring nuclear rupture, especially at high strain rate
Charlotte R. Pfeifera Physical Sciences Oncology Center at Penn (PSOC@penn), University of Pennsylvania, Philadelphia, PA, USA;b Molecular & Cell Biophysics Lab, University of Pennsylvania, Philadelphia, PA, USA;c Graduate Group/Department of Physics & Astronomy, University of Pennsylvania, Philadelphia, PA, USAView further author information
, Michael P. Tobina Physical Sciences Oncology Center at Penn (PSOC@penn), University of Pennsylvania, Philadelphia, PA, USA;b Molecular & Cell Biophysics Lab, University of Pennsylvania, Philadelphia, PA, USA;d Graduate Group/Department of Bioengineering, University of Pennsylvania, Philadelphia, PA, USAView further author information
, Sangkyun Choa Physical Sciences Oncology Center at Penn (PSOC@penn), University of Pennsylvania, Philadelphia, PA, USA;b Molecular & Cell Biophysics Lab, University of Pennsylvania, Philadelphia, PA, USAView further author information
, Manasvita Vashistha Physical Sciences Oncology Center at Penn (PSOC@penn), University of Pennsylvania, Philadelphia, PA, USA;b Molecular & Cell Biophysics Lab, University of Pennsylvania, Philadelphia, PA, USAView further author information
, Lawrence J. Doolinga Physical Sciences Oncology Center at Penn (PSOC@penn), University of Pennsylvania, Philadelphia, PA, USA;b Molecular & Cell Biophysics Lab, University of Pennsylvania, Philadelphia, PA, USAView further author information
, Lizeth Lopez Vazqueza Physical Sciences Oncology Center at Penn (PSOC@penn), University of Pennsylvania, Philadelphia, PA, USA;b Molecular & Cell Biophysics Lab, University of Pennsylvania, Philadelphia, PA, USAView further author information
, Emma G. Ricci-De Luccaa Physical Sciences Oncology Center at Penn (PSOC@penn), University of Pennsylvania, Philadelphia, PA, USA;b Molecular & Cell Biophysics Lab, University of Pennsylvania, Philadelphia, PA, USAView further author information
, Keiann T. Simona Physical Sciences Oncology Center at Penn (PSOC@penn), University of Pennsylvania, Philadelphia, PA, USA;b Molecular & Cell Biophysics Lab, University of Pennsylvania, Philadelphia, PA, USAView further author information
& Dennis E. Dischera Physical Sciences Oncology Center at Penn (PSOC@penn), University of Pennsylvania, Philadelphia, PA, USA;b Molecular & Cell Biophysics Lab, University of Pennsylvania, Philadelphia, PA, USA;c Graduate Group/Department of Physics & Astronomy, University of Pennsylvania, Philadelphia, PA, USA;d Graduate Group/Department of Bioengineering, University of Pennsylvania, Philadelphia, PA, USACorrespondence[email protected]
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Pages 130-144
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Received 10 Oct 2021, Accepted 18 Feb 2022, Published online: 16 Mar 2022
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