Targeting Ewing sarcoma with activated and GD2-specific chimeric antigen receptor-engineered human NK cells induces upregulation of immune-inhibitory HLA-G

Sareetha KailayangiriDepartment of Pediatric Hematology and Oncology, University Children's Hospital Muenster, Muenster, Germany

Bianca AltvaterDepartment of Pediatric Hematology and Oncology, University Children's Hospital Muenster, Muenster, Germany

Christian SpurnyDepartment of Pediatric Hematology and Oncology, University Children's Hospital Muenster, Muenster, Germany

Silke JamitzkyDepartment of Pediatric Hematology and Oncology, University Children's Hospital Muenster, Muenster, Germany

Sonja SchelhaasEuropean Institute for Molecular Imaging (EIMI), University of Muenster, Muenster, Germany

Andreas H. JacobsEuropean Institute for Molecular Imaging (EIMI), University of Muenster, Muenster, Germany;Cells-in-Motion Cluster of Excellence (EXC 1003 – CiM), University of Muenster, Muenster, Germany

Constanze WiekDepartment of Otorhinolaryngology, Head and Neck Surgery, Children's Hospital, Heinrich Heine University, Duesseldorf, Germany

Katharina RoelleckeDepartment of Otorhinolaryngology, Head and Neck Surgery, Children's Hospital, Heinrich Heine University, Duesseldorf, Germany

Helmut HanenbergDepartment of Otorhinolaryngology, Head and Neck Surgery, Children's Hospital, Heinrich Heine University, Duesseldorf, Germany;Department of Pediatrics III, University Children's Hospital Essen, University of Duisburg-Essen, Essen, Germany

Wolfgang HartmannGerhard-Domagk Institute for Pathology, University of Muenster, Muenster, Germany

Heinz WiendlCells-in-Motion Cluster of Excellence (EXC 1003 – CiM), University of Muenster, Muenster, Germany;Department of Neurology, University Hospital Muenster, Muenster, Germany

Susann PankratzDepartment of Neurology, University Hospital Muenster, Muenster, Germany

Jutta MeltzerDepartment of Pediatric Hematology and Oncology, University Children's Hospital Muenster, Muenster, Germany

Nicole FarwickDepartment of Pediatric Hematology and Oncology, University Children's Hospital Muenster, Muenster, Germany

Lea GreuneDepartment of Pediatric Hematology and Oncology, University Children's Hospital Muenster, Muenster, Germany

Maike FlueggeDepartment of Pediatric Hematology and Oncology, University Children's Hospital Muenster, Muenster, Germany

Claudia RossigDepartment of Pediatric Hematology and Oncology, University Children's Hospital Muenster, Muenster, Germany;Cells-in-Motion Cluster of Excellence (EXC 1003 – CiM), University of Muenster, Muenster, GermanyCorrespondence[email protected]

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Targeting Ewing sarcoma with activated and GD2-specific chimeric antigen receptor-engineered human NK cells induces upregulation of immune-inhibitory HLA-G

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Targeting Ewing sarcoma with activated and GD2-specific chimeric antigen receptor-engineered human NK cells induces upregulation of immune-inhibitory HLA-G

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