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Clinical Trials
An old friend who has overstayed their welcome: the ALSFRS-R total score as primary endpoint for ALS clinical trials
Ruben P.A. van Eijk1 Department of Neurology, UMC Utrecht Brain Centre, University Medical Centre Utrecht, Utrecht, The Netherlands;2 Biostatistics & Research Support, Julius Centre for Health Sciences and Primary Care, University Medical Centre Utrecht, Utrecht, The NetherlandsCorrespondence[email protected]
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Adriaan D. de Jongh1 Department of Neurology, UMC Utrecht Brain Centre, University Medical Centre Utrecht, Utrecht, The NetherlandsView further author information
, Stavros Nikolakopoulos2 Biostatistics & Research Support, Julius Centre for Health Sciences and Primary Care, University Medical Centre Utrecht, Utrecht, The NetherlandsView further author information
, Christopher J. McDermott3 Department of Neuroscience, University of Sheffield, Sheffield Institute for Translational Neuroscience, Sheffield, UK, and
https://orcid.org/0000-0002-1269-9053View further author information
Marinus J.C. Eijkemans2 Biostatistics & Research Support, Julius Centre for Health Sciences and Primary Care, University Medical Centre Utrecht, Utrecht, The NetherlandsView further author information
, Kit C.B. Roes2 Biostatistics & Research Support, Julius Centre for Health Sciences and Primary Care, University Medical Centre Utrecht, Utrecht, The Netherlands;4 Department of Health Evidence, Radboud Medical Centre Utrecht, Nijmegen, The NetherlandsView further author information
& Leonard H. van den Berg1 Department of Neurology, UMC Utrecht Brain Centre, University Medical Centre Utrecht, Utrecht, The NetherlandsView further author information
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Pages 300-307
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Received 10 Nov 2020, Accepted 17 Jan 2021, Published online: 02 Feb 2021
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