Unexpected rise in the circulation of complex HBV variants enriched of HBsAg vaccine-escape mutations in HBV genotype-D: potential impact on HBsAg detection/quantification and vaccination strategies

Lorenzo Piermatteoa Department of Biology, Tor Vergata University, Rome, Italy;b Department of Experimental Medicine, Tor Vergata University, Rome, Italy

Stefano D’Annab Department of Experimental Medicine, Tor Vergata University, Rome, Italy

Ada Bertolib Department of Experimental Medicine, Tor Vergata University, Rome, Italy

Maria Bellocchib Department of Experimental Medicine, Tor Vergata University, Rome, Italy

Luca Cariotib Department of Experimental Medicine, Tor Vergata University, Rome, Italy

Lavinia Fabenic National Institute for Infectious Disease, IRCCS L. Spallanzani, Virology and Biosafety Laboratories Unit, Rome, Italy

Mohammad Alkhatibb Department of Experimental Medicine, Tor Vergata University, Rome, Italy

Simone La Fraziaa Department of Biology, Tor Vergata University, Rome, Italy

Miriam Lichtnerd Department of Public Health and Infectious Disease, “Sapienza” University, Rome, Italy

Claudio Mastroiannid Department of Public Health and Infectious Disease, “Sapienza” University, Rome, Italy

Giuseppe De Sanctise “Umberto I” University Hospital, Rome, Italy

Massimo Marignanif Department of Gastroenterology, “S. Andrea Hospital”, Rome, Italy

Caterina Pasquazzif Department of Gastroenterology, “S. Andrea Hospital”, Rome, Italy

Nerio Iapadreg “San Salvatore Hospital”, L’Aquila, Italy

Giustino Parrutih Infectious Diseases Unit, Pescara General Hospital, Pescara, Italy

Giuseppina Cappielloi Microbiology and Virology Unit, “S. Pertini” Hospital, Rome, Italy

Jacopo Vecchietj Clinic of Infectious Diseases, Department of Medicine and Science of Aging, University “G. d'Annunzio” Chieti-Pescara, Chieti, Italy

Vincenzo Malagninok Infectious Diseases Unit, Tor Vergata University Hospital, Rome, Italy

Sandro Grellib Department of Experimental Medicine, Tor Vergata University, Rome, Italy;l Virology Unit, Tor Vergata University Hospital, Rome, Italy

Francesca Ceccherini-Silberteinb Department of Experimental Medicine, Tor Vergata University, Rome, Italy

Massimo Andreonik Infectious Diseases Unit, Tor Vergata University Hospital, Rome, Italy

Loredana Sarmatik Infectious Diseases Unit, Tor Vergata University Hospital, Rome, Italy

Valentina Svichera Department of Biology, Tor Vergata University, Rome, ItalyCorrespondence[email protected]

Romina Salpinia Department of Biology, Tor Vergata University, Rome, Italy

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Unexpected rise in the circulation of complex HBV variants enriched of HBsAg vaccine-escape mutations in HBV genotype-D: potential impact on HBsAg detection/quantification and vaccination strategies

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Unexpected rise in the circulation of complex HBV variants enriched of HBsAg vaccine-escape mutations in HBV genotype-D: potential impact on HBsAg detection/quantification and vaccination strategies

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