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Breast Cancer: Targets and Therapy Volume 16, 2024 - Issue
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CLINICAL TRIAL REPORT

Does the Dose of Standard Adjuvant Chemotherapy Affect the Triple-negative Breast Cancer Benefit from Extended Capecitabine Metronomic Therapy? An Exploratory Analysis of the SYSUCC-001 Trial

Ying Chen1 Department of Breast Surgery, Guangdong Provincial Hospital of Traditional Chinese Medicine, Guangzhou, People’s Republic of China;2 Department of Breast Surgery, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, People’s Republic of ChinaView further author information
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Wen-Xia Li1 Department of Breast Surgery, Guangdong Provincial Hospital of Traditional Chinese Medicine, Guangzhou, People’s Republic of China;2 Department of Breast Surgery, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, People’s Republic of ChinaView further author information
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Jia-Hua Wu1 Department of Breast Surgery, Guangdong Provincial Hospital of Traditional Chinese Medicine, Guangzhou, People’s Republic of China;2 Department of Breast Surgery, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, People’s Republic of ChinaView further author information
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Geng-Hang Chen2 Department of Breast Surgery, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, People’s Republic of ChinaView further author information
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Chun-Min Yang1 Department of Breast Surgery, Guangdong Provincial Hospital of Traditional Chinese Medicine, Guangzhou, People’s Republic of China;2 Department of Breast Surgery, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, People’s Republic of ChinaView further author information
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Hai Lu1 Department of Breast Surgery, Guangdong Provincial Hospital of Traditional Chinese Medicine, Guangzhou, People’s Republic of China;2 Department of Breast Surgery, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, People’s Republic of ChinaView further author information
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Xi Wang3 Department of Breast Oncology, Sun Yat-sen University Cancer Center, the State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, People’s Republic of ChinaView further author information
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Shu-Sen Wang4 Department of Medical Oncology, Sun Yat-sen University Cancer Center, the State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, People’s Republic of ChinaView further author information
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Heng Huang5 Department of Breast Oncology, Lianjiang People’s Hospital, Lianjiang, People’s Republic of ChinaView further author information
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Li Cai6 Department of Medical Oncology, The Affiliated Tumour Hospital of Harbin Medical University, Harbin, People’s Republic of ChinaView further author information
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Li Zhao7 Department of Breast Oncology, Guangzhou First People Hospital, Guangzhou, People’s Republic of ChinaView further author information
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Rou-Jun Peng8 Department of Integrated Therapy in Oncology, Sun Yat-sen University Cancer Center, the State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, People’s Republic of ChinaView further author information
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Ying Lin9 Department of Breast Oncology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, People’s Republic of ChinaView further author information
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Jun Tang3 Department of Breast Oncology, Sun Yat-sen University Cancer Center, the State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, People’s Republic of ChinaView further author information
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Jian Zeng10 Department of Breast Oncology, The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, People’s Republic of ChinaView further author information
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Le-Hong Zhang11 Department of Breast Oncology, The Second Affiliated Hospital of Guangzhou Medical University, Guangzhou, People’s Republic of ChinaView further author information
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Yong-Li Ke12 Department of Breast Oncology, General Hospital of PLA Guangzhou Military Area, Guangzhou, People’s Republic of ChinaView further author information
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Xian-Ming Wang13 Department of Breast Oncology, Shenzhen Second People’s Hospital, Shenzhen, People’s Republic of ChinaView further author information
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Xin-Mei Liu14 Department of Breast Oncology, Haikou People’s Hospital, Haikou, People’s Republic of ChinaView further author information
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An-Qin Zhang15 Department of Breast Oncology, Maternal and Child Health Care Hospital of Guangdong Province, Guangzhou, People’s Republic of ChinaView further author information
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Fei Xu4 Department of Medical Oncology, Sun Yat-sen University Cancer Center, the State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, People’s Republic of ChinaORCID Iconhttps://orcid.org/0000-0001-8543-6636View further author information
ORCID Icon,
Xi-Wen Bi4 Department of Medical Oncology, Sun Yat-sen University Cancer Center, the State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, People’s Republic of ChinaView further author information
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Jia-Jia Huang4 Department of Medical Oncology, Sun Yat-sen University Cancer Center, the State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, People’s Republic of ChinaView further author information
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Ji-Bin Li16 Department of Good Clinical Practice, Sun Yat-sen University Cancer Center, the State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, People’s Republic of ChinaORCID Iconhttps://orcid.org/0000-0001-7632-3648View further author information
ORCID Icon,
Dan-Mei Pang17 Department of Medical Oncology, Foshan First People’s Hospital, Foshan, People’s Republic of ChinaView further author information
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Cong Xue4 Department of Medical Oncology, Sun Yat-sen University Cancer Center, the State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, People’s Republic of ChinaORCID Iconhttps://orcid.org/0000-0003-3558-8572View further author information
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Yan-Xia Shi4 Department of Medical Oncology, Sun Yat-sen University Cancer Center, the State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, People’s Republic of ChinaView further author information
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Zhen-Yu He18 Department of Radiotherapy, Sun Yat-sen University Cancer Center, the State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, People’s Republic of ChinaORCID Iconhttps://orcid.org/0000-0003-1402-8963View further author information
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Huan-Xin Lin18 Department of Radiotherapy, Sun Yat-sen University Cancer Center, the State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, People’s Republic of ChinaORCID Iconhttps://orcid.org/0000-0002-0621-4486View further author information
ORCID Icon,
Xin An4 Department of Medical Oncology, Sun Yat-sen University Cancer Center, the State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, People’s Republic of ChinaORCID Iconhttps://orcid.org/0000-0003-0683-5511View further author information
ORCID Icon,
Wen Xia4 Department of Medical Oncology, Sun Yat-sen University Cancer Center, the State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, People’s Republic of ChinaView further author information
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Ye Cao16 Department of Good Clinical Practice, Sun Yat-sen University Cancer Center, the State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, People’s Republic of ChinaView further author information
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Ying Guo16 Department of Good Clinical Practice, Sun Yat-sen University Cancer Center, the State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, People’s Republic of ChinaView further author information
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Ruo-Xi Hong4 Department of Medical Oncology, Sun Yat-sen University Cancer Center, the State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, People’s Republic of ChinaView further author information
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Kui-Kui Jiang4 Department of Medical Oncology, Sun Yat-sen University Cancer Center, the State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, People’s Republic of ChinaORCID Iconhttps://orcid.org/0000-0003-4498-8404View further author information
ORCID Icon,
Yong-Yi Zhong4 Department of Medical Oncology, Sun Yat-sen University Cancer Center, the State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, People’s Republic of ChinaView further author information
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Ge Zhang19 Law Sau Fai Institute for Advancing Translational Medicine in Bone and Joint Diseases (TMBJ), School of Chinese Medicine, Hong Kong Baptist University, Hong KongView further author information
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Piyawan Tienchaiananda20 Division of Medical Oncology, Department of Medicine, Faculty of Medicine, Rangsit University, Rajavithi Hospital, Bangkok, ThailandView further author information
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Masahiro Oikawa21 The Department of Breast Surgery, New-wa-kai Oikawa Hospital, Fukuoka, JapanView further author information
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Zhong-Yu Yuan4 Department of Medical Oncology, Sun Yat-sen University Cancer Center, the State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, People’s Republic of ChinaCorrespondence[email protected]
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Qian-Jun Chen22 State Key Laboratory of Traditional Chinese Medicine Syndrome/Departments of Gynecologic Oncology, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, People’s Republic of China;23 State Key Laboratory of Traditional Chinese Medicine Syndrome, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, People’s Republic of ChinaCorrespondence[email protected]
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Pages 223-231 | Received 30 Nov 2023, Accepted 27 Mar 2024, Published online: 12 Apr 2024

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