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ORIGINAL RESEARCH
New IMB16-4 Hot-Melt Extrusion Preparation Improved Oral Bioavailability and Enhanced Anti-Cholestatic Effect on Rats
Yuqin Li1 Graduate School, Hebei Medical University, Shijiazhuang, People’s Republic of China;2 Hebei Key Laboratory of Metabolic Diseases, Hebei General Hospital, Shijiazhuang, People’s Republic of China
, Changlin Tian1 Graduate School, Hebei Medical University, Shijiazhuang, People’s Republic of China;2 Hebei Key Laboratory of Metabolic Diseases, Hebei General Hospital, Shijiazhuang, People’s Republic of China
, Xiaofei Song3 Department of Otolaryngology, Hebei General Hospital, Shijiazhuang, People’s Republic of China
, Mengying Du4 Performance Assessment Department, Quality Management Department, Hebei General Hospital, Shijiazhuang, People’s Republic of China
, Guoning Zhang5 Institute of Medicinal Biotechnology, Chinese Academy of Medical Science and Peking Union Medical College, Beijing, People’s Republic of Chinahttps://orcid.org/0000-0003-1736-6749
& Hongtao Liu2 Hebei Key Laboratory of Metabolic Diseases, Hebei General Hospital, Shijiazhuang, People’s Republic of ChinaCorrespondence[email protected]
Pages 649-657
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Received 27 Oct 2022, Accepted 16 Feb 2023, Published online: 28 Feb 2023
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