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Original Research
Safety profile of solid lipid nanoparticles loaded with rosmarinic acid for oral use: in vitro and animal approaches
Ana Raquel Madureira1 Catholic University of Portugal, CBQF – Center for Biotechnology and Fine Chemistry – Associate Laboratory, Faculty of Biotechnology, Porto, Portugal
, Sara Nunes2 Laboratory of Pharmacology and Experimental Therapeutics, Institute for Biomedical Imaging and Life Sciences (IBILI), Faculty of Medicine, and CNC.IBILI Consortium, University of Coimbra, Coimbra, Portugal
, Débora A Campos1 Catholic University of Portugal, CBQF – Center for Biotechnology and Fine Chemistry – Associate Laboratory, Faculty of Biotechnology, Porto, Portugal
, João C Fernandes2 Laboratory of Pharmacology and Experimental Therapeutics, Institute for Biomedical Imaging and Life Sciences (IBILI), Faculty of Medicine, and CNC.IBILI Consortium, University of Coimbra, Coimbra, Portugal
, Cláudia Marques3 Department of Biochemistry, Faculty of Medicine, University of Porto, Porto, Portugal
, Monica Zuzarte2 Laboratory of Pharmacology and Experimental Therapeutics, Institute for Biomedical Imaging and Life Sciences (IBILI), Faculty of Medicine, and CNC.IBILI Consortium, University of Coimbra, Coimbra, Portugal
, Beatriz Gullón1 Catholic University of Portugal, CBQF – Center for Biotechnology and Fine Chemistry – Associate Laboratory, Faculty of Biotechnology, Porto, Portugal
, Luís M Rodríguez-Alcalá1 Catholic University of Portugal, CBQF – Center for Biotechnology and Fine Chemistry – Associate Laboratory, Faculty of Biotechnology, Porto, Portugal
, Conceição Calhau3 Department of Biochemistry, Faculty of Medicine, University of Porto, Porto, Portugal;4 Center for Health Technology and Services Research (CINTESIS), Porto, Portugal
, Bruno Sarmento5 Department of Pharmaceutical Sciences, Institute of Health Sciences-North, CESPU, Gandra, Portugal;6 “I3S” Instituto de Investigação e Inovação em Saúde, University of Porto, Porto, Portugal;7 INEB, Institute of Biomedical Engineering, University of Porto, Porto, Portugal
, Ana Maria Gomes1 Catholic University of Portugal, CBQF – Center for Biotechnology and Fine Chemistry – Associate Laboratory, Faculty of Biotechnology, Porto, Portugal
, Maria Manuela Pintado1 Catholic University of Portugal, CBQF – Center for Biotechnology and Fine Chemistry – Associate Laboratory, Faculty of Biotechnology, Porto, Portugal
& Flávio Reis2 Laboratory of Pharmacology and Experimental Therapeutics, Institute for Biomedical Imaging and Life Sciences (IBILI), Faculty of Medicine, and CNC.IBILI Consortium, University of Coimbra, Coimbra, PortugalCorrespondence[email protected]
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Pages 3621-3640
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Published online: 04 Aug 2016
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