Involvement of complement activation in the pulmonary vasoactivity of polystyrene nanoparticles in pigs: unique surface properties underlying alternative pathway activation and instant opsonization

Tamás Mészáros1 Nanomedicine Research and Education Center, Department of Pathophysiology, Semmelweis University, Budapest, Hungary, [email protected];2 SeroScience Ltd, Budapest, Hungary, [email protected]

Gergely Tibor Kozma2 SeroScience Ltd, Budapest, Hungary, [email protected]

Taro Shimizu3 Department of Pharmacokinetics and Biopharmaceutics, Institute of Biomedical Sciences, Tokushima University, Tokushima, Japan

Koga Miyahara3 Department of Pharmacokinetics and Biopharmaceutics, Institute of Biomedical Sciences, Tokushima University, Tokushima, Japan

Keren Turjeman4 Laboratory of Membrane and Liposome Research, Department of Biochemistry and Molecular Biology, Institute for Medical Research Israel-Canada (IMRIC), The Hebrew University-Hadassah Medical School, Jerusalem, Israel

Tatsuhiro Ishida3 Department of Pharmacokinetics and Biopharmaceutics, Institute of Biomedical Sciences, Tokushima University, Tokushima, Japan

Yechezkel Barenholz4 Laboratory of Membrane and Liposome Research, Department of Biochemistry and Molecular Biology, Institute for Medical Research Israel-Canada (IMRIC), The Hebrew University-Hadassah Medical School, Jerusalem, Israel

Rudolf Urbanics1 Nanomedicine Research and Education Center, Department of Pathophysiology, Semmelweis University, Budapest, Hungary, [email protected];2 SeroScience Ltd, Budapest, Hungary, [email protected]

János Szebeni1 Nanomedicine Research and Education Center, Department of Pathophysiology, Semmelweis University, Budapest, Hungary, [email protected];2 SeroScience Ltd, Budapest, Hungary, [email protected];5 Department of Nanobiotechnology and Regenerative Medicine, Faculty of Health, Miskolc University, Miskolc, Hungary, [email protected]Correspondence[email protected]

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Involvement of complement activation in the pulmonary vasoactivity of polystyrene nanoparticles in pigs: unique surface properties underlying alternative pathway activation and instant opsonization

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Involvement of complement activation in the pulmonary vasoactivity of polystyrene nanoparticles in pigs: unique surface properties underlying alternative pathway activation and instant opsonization

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