High-efficiency liposomal encapsulation of a tyrosine kinase inhibitor leads to improved in vivo toxicity and tumor response profile

Rajesh Mukthavaram1 Translational Neuro-Oncology Laboratories, Moores Cancer Center, UC San Diego, La Jolla, CA, USA

Pengfei Jiang1 Translational Neuro-Oncology Laboratories, Moores Cancer Center, UC San Diego, La Jolla, CA, USA

Rohit Saklecha1 Translational Neuro-Oncology Laboratories, Moores Cancer Center, UC San Diego, La Jolla, CA, USA

Dmitri Simberg3 Solid Tumor Therapeutics Program, Moores Cancer Center, UC San Diego, La Jolla, CA, USA;4 Skaggs School of Pharmacy and Pharmaceutical Sciences, University of Colorado, Denver, CO, USA

Ila Sri Bharati1 Translational Neuro-Oncology Laboratories, Moores Cancer Center, UC San Diego, La Jolla, CA, USA

Natsuko Nomura1 Translational Neuro-Oncology Laboratories, Moores Cancer Center, UC San Diego, La Jolla, CA, USA

Ying Chao1 Translational Neuro-Oncology Laboratories, Moores Cancer Center, UC San Diego, La Jolla, CA, USA

Sandra Pastorino1 Translational Neuro-Oncology Laboratories, Moores Cancer Center, UC San Diego, La Jolla, CA, USA

Sandeep C Pingle1 Translational Neuro-Oncology Laboratories, Moores Cancer Center, UC San Diego, La Jolla, CA, USA

Valentina Fogal1 Translational Neuro-Oncology Laboratories, Moores Cancer Center, UC San Diego, La Jolla, CA, USA

Wolf Wrasidlo1 Translational Neuro-Oncology Laboratories, Moores Cancer Center, UC San Diego, La Jolla, CA, USA;2 Department of Neurosciences, Moores Cancer Center, UC San Diego, La Jolla, CA, USA

Milan Makale1 Translational Neuro-Oncology Laboratories, Moores Cancer Center, UC San Diego, La Jolla, CA, USA;2 Department of Neurosciences, Moores Cancer Center, UC San Diego, La Jolla, CA, USACorrespondence[email protected]

Santosh Kesari1 Translational Neuro-Oncology Laboratories, Moores Cancer Center, UC San Diego, La Jolla, CA, USA;2 Department of Neurosciences, Moores Cancer Center, UC San Diego, La Jolla, CA, USACorrespondence[email protected]

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High-efficiency liposomal encapsulation of a tyrosine kinase inhibitor leads to improved in vivo toxicity and tumor response profile

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High-efficiency liposomal encapsulation of a tyrosine kinase inhibitor leads to improved in vivo toxicity and tumor response profile

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