Bupivacaine in alginate and chitosan nanoparticles: an in vivo evaluation of efficacy, pharmacokinetics, and local toxicity

Cíntia Maria Saia Cereda1 Institute and Research Center São Leopoldo Mandic, Campinas, São Paulo, Brazil

Daniel Sebbe Mecatti2 UNIFAG, São Francisco University, Bragança Paulista, São Paulo, Brazil

Juliana Zampoli Boava Papini1 Institute and Research Center São Leopoldo Mandic, Campinas, São Paulo, Brazil

Diego Valério Bueno2 UNIFAG, São Francisco University, Bragança Paulista, São Paulo, Brazil

Michelle Franz-Montan3 Department of Physiological Sciences, University of Campinas, Piracicaba, São Paulo, Brazil

Thalita Rocha2 UNIFAG, São Francisco University, Bragança Paulista, São Paulo, Brazil

José Pedrazzoli Júnior2 UNIFAG, São Francisco University, Bragança Paulista, São Paulo, Brazil

Eneida de Paula4 Department of Biochemistry and Tissue Biology, University of Campinas, Campinas, São Paulo, Brazil

Daniele Ribeiro de Araújo5 Human and Natural Science Centre, Federal University of ABC, Santo André, São Paulo, Brazil

Renato Grillo6 Department of Physics and Chemistry, School of Engineering, São Paulo State University (UNESP), Ilha Solteira, São Paulo, Brazil

Leonardo Fernandes Fraceto7 Department of Environmental Engineering, São Paulo State University (UNESP), Sorocaba, São Paulo, Brazil

Silvana Aparecida Calafatti2 UNIFAG, São Francisco University, Bragança Paulista, São Paulo, Brazil

Giovana Radomille Tofoli1 Institute and Research Center São Leopoldo Mandic, Campinas, São Paulo, BrazilCorrespondence[email protected]

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