Evaluation of a chimeric (uPA+/+)/SCID mouse model with a humanized liver for prediction of human metabolism

Mark De SerresPreclinical Drug Metabolism and Pharmacokinetics, GlaxoSmithKline, Research Triangle Park, NC, USACorrespondence[email protected]

Gary BowersPreclinical Drug Metabolism and Pharmacokinetics, GlaxoSmithKline, Research Triangle Park, NC, USA

Gary BoyleWare, Hertfordshire, UK

Claire BeaumontWare, Hertfordshire, UK

Steve CastellinoPreclinical Drug Metabolism and Pharmacokinetics, GlaxoSmithKline, Research Triangle Park, NC, USA

James SigafoosPreclinical Drug Metabolism and Pharmacokinetics, GlaxoSmithKline, Research Triangle Park, NC, USA

Mehul DaveWare, Hertfordshire, UK

Andrew RobertsWare, Hertfordshire, UK

Vishal ShahPreclinical Drug Metabolism and Pharmacokinetics, GlaxoSmithKline, Research Triangle Park, NC, USA

Katie OlsonPreclinical Drug Metabolism and Pharmacokinetics, GlaxoSmithKline, Research Triangle Park, NC, USA

Dipak PatelPreclinical Drug Metabolism and Pharmacokinetics, GlaxoSmithKline, Research Triangle Park, NC, USA

David WagnerPreclinical Drug Metabolism and Pharmacokinetics, GlaxoSmithKline, Research Triangle Park, NC, USA

Russell YeagerPreclinical Drug Metabolism and Pharmacokinetics, GlaxoSmithKline, Research Triangle Park, NC, USA

Cosette Serabjit-SinghPreclinical Drug Metabolism and Pharmacokinetics, GlaxoSmithKline, Research Triangle Park, NC, USA

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