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Xenobiotica
the fate of foreign compounds in biological systems
Volume 46, 2016 - Issue 11
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General Xenobiochemistry

Single concentration loss of activity assay provides an improved assessment of drug–drug interaction risk compared to IC50-shift

Simon G. WongDepartment of Pharmacokinetics and Drug Metabolism, Amgen, South San Francisco, CA, USACorrespondence[email protected]
,
Mey LeeDepartment of Pharmacokinetics and Drug Metabolism, Amgen, South San Francisco, CA, USA
&
Bradley K. WongDepartment of Pharmacokinetics and Drug Metabolism, Amgen, South San Francisco, CA, USA
Pages 953-966 | Received 30 Oct 2015, Accepted 13 Jan 2016, Published online: 09 Mar 2016

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