Stereoselective hydroxylation by CYP2C19 and oxidation by ADH4 in the in vitro metabolism of tivantinib

Yumi NishiyaDrug Metabolism and Pharmacokinetics Research Laboratories, Daiichi Sankyo Co., Ltd., Tokyo, Japan, Correspondence[email protected]

Daisuke NakaiDrug Metabolism and Pharmacokinetics Research Laboratories, Daiichi Sankyo Co., Ltd., Tokyo, Japan,

Yoko UrasakiDrug Metabolism and Pharmacokinetics Research Laboratories, Daiichi Sankyo Co., Ltd., Tokyo, Japan,

Hideo TakakusaDrug Metabolism and Pharmacokinetics Research Laboratories, Daiichi Sankyo Co., Ltd., Tokyo, Japan,

Satoru OhsukiOrganic Synthesis Department, Daiichi Sankyo RD Novare Co., Ltd., Tokyo, Japan,

Yuji IwanoOrganic Synthesis Department, Daiichi Sankyo RD Novare Co., Ltd., Tokyo, Japan,

Takanori YasukochiOrganic Synthesis Department, Daiichi Sankyo RD Novare Co., Ltd., Tokyo, Japan,

Tomoko TakayamaDiscovery Science and Technology Department, Daiichi Sankyo RD Novare Co., Ltd., Tokyo, Japan,

Shohei BazyoDiscovery Science and Technology Department, Daiichi Sankyo RD Novare Co., Ltd., Tokyo, Japan,

Chikahiro OzaDiscovery Science and Technology Department, Daiichi Sankyo RD Novare Co., Ltd., Tokyo, Japan,

Atsushi KuriharaDrug Metabolism and Pharmacokinetics Research Laboratories, Daiichi Sankyo Co., Ltd., Tokyo, Japan,

Ronald E SavageArQule, Inc., Woburn, MA, USA, and

Takashi IzumiResearch Function, Daiichi Sankyo Co., Ltd., Tokyo, Japan

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