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Xenobiotica
the fate of foreign compounds in biological systems
Volume 16, 1986 - Issue 6
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Original Article

The rate of N-demethylation of N,N-dimethylanilines and N-methylanilines by rat-liver microsomes is related to their first ionization potential, their lipophilicity and to a steric bulk factor

G. Galliani Istituto di Chimica Organica dell'Università, via Venezian, 1-20133, Milan, Italy
,
M. Nali Istituto di Chimica Organica dell'Università, via Venezian, 1-20133, Milan, Italy
,
B. Rindone Istituto di Chimica Organica dell'Università, via Venezian, 1-20133, Milan, Italy
,
S. Tollari Istituto di Chimica Organica dell'Università, via Venezian, 1-20133, Milan, Italy
,
M. Rocchetti Istituto di Richerche Farmacologiche “Mario Negri”, via Eritrea, 62-20157, Milan, Italy
&
M. Salmona Istituto di Richerche Farmacologiche “Mario Negri”, via Eritrea, 62-20157, Milan, Italy
Pages 511-517 | Received 26 Feb 1985, Published online: 30 Sep 2009

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