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Drug Development and Industrial Pharmacy Volume 37, 2011 - Issue 9
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Research Article

Co-administration of a nanosuspension of a poorly soluble basic compound and a solution of a proton pump inhibitor—the importance of gastrointestinal pH and solubility for the in vivo exposure

Kalle SigfridssonCorrespondence[email protected]
,
Anders LundqvistDiscovery Drug Metabolism and Pharmacokinetics & Bioanalytical Chemistry, AstraZeneca R&D Mölndal, S-431 83 Mölndal, Sweden
&
Marie StrimforsDiscovery Drug Metabolism and Pharmacokinetics & Bioanalytical Chemistry, AstraZeneca R&D Mölndal, S-431 83 Mölndal, Sweden
Pages 1036-1042 | Received 05 Jul 2010, Accepted 25 Jan 2011, Published online: 21 Mar 2011

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