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Position Papers

Applying extracellular vesicles based therapeutics in clinical trials – an ISEV position paper

Thomas LenerSpinal Cord Injury & Tissue Regeneration Center Salzburg (SCI-TReCS), Paracelsus Medical University (PMU), Salzburg, Austria;Department of Blood Group Serology and Transfusion MedicineUniversity Hospital, Salzburger Landeskliniken GesmbH (SALK), Salzburg, Austria

Mario GimonaSpinal Cord Injury & Tissue Regeneration Center Salzburg (SCI-TReCS), Paracelsus Medical University (PMU), Salzburg, Austria;Department of Blood Group Serology and Transfusion MedicineUniversity Hospital, Salzburger Landeskliniken GesmbH (SALK), Salzburg, Austria

Ludwig AignerSpinal Cord Injury & Tissue Regeneration Center Salzburg (SCI-TReCS), Paracelsus Medical University (PMU), Salzburg, Austria

Verena BörgerInstitute for Transfusion MedicineUniversity Hospital Essen, University of Duisburg-Essen, Essen, Germany

Edit BuzasDepartment of GeneticsCell- and Immunobiology, Semmelweis University, Budapest, Hungary

Giovanni CamussiMolecular Biotechnology CenterDepartment of Medical Sciences, University of Turin, Turin, Italy

Nathalie ChaputLaboratory of Immunomonitoring in Oncology, UMS 3655 CNRS/US23 Inserm, Villejuif, France;Centre of Clinical Investigation in Biotherapy CICBT 1248, Institut Gustave Roussy, Villejuif, France

Devasis ChatterjeeDivision of Hematology & Oncology, Rhode Island Hospital, Providence, RI, USA;The Alpert Medical School of Brown University Providence, RI, USA

Felipe A. CourtDepartment of Physiology Faculty of Biology, Pontificia-Universidad Católica de Chile, Santiago, Chile

Hernando A. del PortilloICREA at Barcelona Centre for International Health Research (CRESIB), Hospital Clínic – Universitat de Barcelona, Barcelona, Spain;Institut d'Investigació Germans Trias i Pujol (IGTP), Badalona, Spain

Lorraine O'DriscollSchool of Pharmacy and Pharmaceutical SciencesTrinity College Dublin, Dublin 2, Ireland;;Trinity Biomedical Sciences Institute Trinity College Dublin, Dublin 2, Ireland

Stefano FaisAnti-Tumor Drugs SectionDepartment of Therapeutic Research and Medicines Evaluation, National Institute of Health (ISS), Rome, Italy

Juan M. Falcon-PerezMetabolomics Unit CIC bioGUNE, CIBERehd, Bizkaia Technology Park, Derio, Spain;IKERBASQUEBasque Foundation for Science, Bilbao, Spain

Ursula Felderhoff-MueserDepartment of Paediatrics I Neonatology, University Hospital Essen, University Duisburg-Essen, Essen, Germany

Lorenzo FraileDepartament de Producció Animal, ETSEA, Universitat de Lleida, Lleida, Spain

Yong Song GhoDepartment of Life SciencesPohang University of Science and Technology, Pohang, Republic of Korea

André GörgensInstitute for Transfusion MedicineUniversity Hospital Essen, University of Duisburg-Essen, Essen, Germany

Ramesh C. GuptaDepartment of Pharmacology and ToxicologyUniversity of Louisville, Louisville, KY, USA;James Graham Brown Cancer CenterUniversity of Louisville, Louisville, KY, USA

An HendrixLaboratory of Experimental Cancer Research Department of Radiation Oncology and Experimental Cancer Research, Ghent University Hospital, Ghent, Belgium

Dirk M. HermannDepartment of NeurologyUniversity Hospital Essen, University of Duisburg-Essen, Essen, Germany

Andrew F. HillDepartment of Biochemistry and Genetics, La Trobe Institute for Molecular Science, La Trobe University, Melbourne, Australia

Fred HochbergMassachusetts General Hospital, Boston, MA, USA

Peter A. HornInstitute for Transfusion MedicineUniversity Hospital Essen, University of Duisburg-Essen, Essen, Germany

Dominique de KleijnDepartment of SurgeryYLL School of Medicine, NUS, Singapore, Singapore

Lambros KordelasDepartment of Bone Marrow TransplantationUniversity Hospital Essen, University of Duisburg-Essen, Essen, Germany

Boris W. KramerExperimental Perinatology/NeonatologySchool of Mental Health and Neuroscience, School of Oncology and Developmental Biology, Maastricht University Medical Center, Maastricht, The Netherlands

Eva-Maria Krämer-AlbersMolecular Cell Biology and Focus Program Translational NeurosciencesUniversity of Mainz, Mainz, Germany

Sandra Laner-PlambergerSpinal Cord Injury & Tissue Regeneration Center Salzburg (SCI-TReCS), Paracelsus Medical University (PMU), Salzburg, Austria;Department of Blood Group Serology and Transfusion MedicineUniversity Hospital, Salzburger Landeskliniken GesmbH (SALK), Salzburg, Austria

Saara LaitinenResearch and Cell ServicesFinnish Red Cross Blood Service, Helsinki, Finland

Tommaso LeonardiDivision of Stem Cell Neurobiology, Department of Clinical Neurosciences, Wellcome Trust-Medical Research Council Stem Cell Institute, University of Cambridge, Cambridge, UK;European Molecular Biology LaboratoryEuropean Bioinformatics Institute (EMBL-EBI), Cambridge, UK

Magdalena J. LorenowiczDepartment of Cell BiologyCenter for Molecular Medicine, University Medical Center, Utrecht, The Netherlands

Sai Kiang LimInstitute of Medical BiologyAgency for Science Technology and Research (A*STAR), Singapore, Singapore

Jan LötvallKrefting Research Centre, Institute of Medicine, the Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden

Casey A. MaguireHarvard Medical School, Massachusetts General Hospital, Boston, MA, USA

Antonio MarcillaDpto. Biología Celular y ParasitologiaFacultat de Farmacia, Universitat de Valencia, Valencia, Spain;Joint Research Unit on EndocrinologyNutrition and Clinical Dietetics, Universitat de València-Health Research Institute La Fe, Valencia, Spain

Irina NazarenkoInstitute for Environmental Health Sciences and Hospital Infection Control Medical CenterUniversity of Freiburg, Freiburg im Breisgau, Germany

Takahiro OchiyaDivision of Molecular and Cellular MedicineNational Cancer Center Research Institute, Tokyo, Japan

Tushar PatelDepartments of Transplantation and Cancer BiologyMayo Clinic, Jacksonville, FL, USA

Shona PedersenCentre for Cardiovascular Research, Department of Clinical Biochemistry, Aalborg University Hospital, Aalborg University, Aalborg, Denmark

Gabriella PocsfalviMass Spectrometry and ProteomicsInstitute of Biosciences and BioResources, National Research Council of Italy, Naples, Italy

Stefano PluchinoDivision of Stem Cell Neurobiology, Department of Clinical Neurosciences, Wellcome Trust-Medical Research Council Stem Cell Institute, University of Cambridge, Cambridge, UK

Peter QuesenberryDivision of Hematology & Oncology, Rhode Island Hospital, Providence, RI, USA;The Alpert Medical School of Brown University Providence, RI, USA

Ilona G. ReischlBASG – Bundesamt für Sicherheit im Gesundheitswesen – Federal Office for Safety in Health Care, AGES – Agentur für Gesundheit und Ernährungssicherheit – Austrian Agency for Health and Food Safety, Institut Überwachung – Institute Surveillance, Wien, Austria

Francisco J. RiveraInstitute of Molecular Regenerative MedicineSpinal Cord Injury & Tissue Regeneration Center Salzburg (SCI-TReCS), Paracelsus Medical University (PMU), Salzburg, Austria;

Ralf SanzenbacherRalf Sanzenbacher Paul-Ehrlich-Institut, Bundesinstitut für Impfstoffe und biomedizinische Arzneimittel, Federal Institute for Vaccines and Biomedicines, Langen, Germany

Katharina SchallmoserSpinal Cord Injury & Tissue Regeneration Center Salzburg (SCI-TReCS), Paracelsus Medical University (PMU), Salzburg, Austria;Department of Blood Group Serology and Transfusion MedicineUniversity Hospital, Salzburger Landeskliniken GesmbH (SALK), Salzburg, Austria

Ineke Slaper-CortenbachCell Therapy Facility Department of Clinical Pharmacy, University Medical Center Utrecht, Utrecht, The Netherlands

Dirk StrunkExperimental & Clinical Cell Therapy InstituteSpinal Cord Injury & Tissue Regeneration Center Salzburg (SCI-TReCS), Paracelsus Medical University, Salzburg, Austria

Torsten TonnInstitute for Transfusion Medicine DresdenGerman Red Cross Blood Donation Service North-East, Dresden, Germany

Pieter VaderLaboratory of Clinical Chemistry and HematologyUniversity Medical Center Utrecht, Utrecht, The Netherlands;Department of PhysiologyAnatomy and Genetics, University of Oxford, Oxford, UK

Bas W. M. van BalkomDepartment of Nephrology and HypertensionUniversity Medical Center Utrecht, Utrecht, The Netherlands

Marca WaubenDepartment of Biochemistry and Cell BiologyFaculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands

Samir El AndaloussiDepartment of PhysiologyAnatomy and Genetics, University of Oxford, Oxford, UK;Department of Laboratory MedicineKarolinska Institutet, Stockholm, Sweden

Clotilde ThéryCentre of Clinical Investigation in Biotherapy CICBT 1248, Institut Gustave Roussy, Villejuif, France;INSERM U932 Institut Curie, Paris, France

Eva RohdeSpinal Cord Injury & Tissue Regeneration Center Salzburg (SCI-TReCS), Paracelsus Medical University (PMU), Salzburg, Austria;Department of Blood Group Serology and Transfusion MedicineUniversity Hospital, Salzburger Landeskliniken GesmbH (SALK), Salzburg, AustriaCorrespondence[email protected] [email protected]

Bernd GiebelInstitute for Transfusion MedicineUniversity Hospital Essen, University of Duisburg-Essen, Essen, GermanyCorrespondence[email protected] [email protected]

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Applying extracellular vesicles based therapeutics in clinical trials – an ISEV position paper

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