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Management

Systematic review of antioxidant types and doses in male infertility: Benefits on semen parameters, advanced sperm function, assisted reproduction and live-birth rateFootnote

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Pages 113-124 | Received 30 Sep 2017, Accepted 22 Nov 2017, Published online: 18 Mar 2019

References

  • I.D.SharlipJ.P.JarowA.M.BelkerL.I.LipshultzM.SigmanA.J.Thomaset alBest practice policies for male infertilityFertil Steril772002873882
  • A.AgarwalA.MulgundA.HamadaM.R.ChyatteA unique view on male infertility around the globeReprod Biol Endocrinol1320153710.1186/s12958-015-0032-1
  • B.HalliwellFree radicals and vascular disease: how much do we know?BMJ3071993885886
  • C.E.FordK.W.JonesO.J.MillerU.MittwochL.S.PenroseM.Ridleret alThe chromosomes in a patient showing both mongolism and the Klinefelter syndromeLancet11959709710
  • R.J.BrookerGenetics: analysis and principles4th ed.2011McGraw-Hill Higher EducationOhio, USA
  • R.J.AitkenJ.S.ClarksonS.FishelGeneration of reactive oxygen species, lipid peroxidation, and human sperm functionBiol Reprod411989183197
  • H.SiesStrategies of antioxidant defenseEur J Biochem2151993213219
  • A.AgarwalA.MajzoubS.C.EstevesE.KoR.RamasamyA.ZiniClinical utility of sperm DNA fragmentation testing: practice recommendations based on clinical scenariosTransl Androl Urol52016935950
  • A.AgarwalR.K.SharmaK.P.NallellaA.J.ThomasJrJ.G.AlvarezS.C.SikkaReactive oxygen species as an independent marker of male factor infertilityFertil Steril862006878885
  • K.TremellenOxidative stress and male infertility–a clinical perspectiveHum Reprod Update142008243258
  • A.AgarwalR.A.SalehM.A.BedaiwyRole of reactive oxygen species in the pathophysiology of human reproductionFertil Steril792003829843
  • P.GharagozlooA.Gutiérrez-AdánA.ChamprouxA.NoblancA.KocerA.Calleet alA novel antioxidant formulation designed to treat male infertility associated with oxidative stress: promising preclinical evidence from animal modelsHum Reprod3120162522562
  • M.G.ElSheikhM.B.HosnyA.ElshenoufyH.ElghamrawiA.FayadS.AbdelrahmanCombination of vitamin E and clomiphene citrate in treating patients with idiopathic oligoasthenozoospermia: a prospective, randomized trialAndrology32015864867
  • G.Paradiso GalatiotoG.L.GravinaG.AngelozziA.SacchettiP.F.InnominatoG.Paceet alMay antioxidant therapy improve sperm parameters of men with persistent oligospermia after retrograde embolization for varicocele?World J Urol26200897102
  • S.PeivandiA.KarimpourN.MoslemizadehEffects of l-carnitine on infertile men’s spermogram; a randomized clinical trialJ Reprod Infertil102010245251
  • M.R.SafarinejadEfficacy of coenzyme Q10 on semen parameters, sperm function and reproductive hormones in infertile menJ Urol1822009237248
  • M.R.SafarinejadS.SafarinejadEfficacy of selenium and/or N-acetyl-cysteine for improving semen parameters in infertile men: a double-blind, placebo controlled, randomized studyJ Urol1812009741751
  • W.Y.WongH.M.MerkusC.M.ThomasR.MenkveldG.A.ZielhuisR.P.Steegers-TheunissenEffects of folic acid and zinc sulfate on male factor subfertility: a double-blind, randomized, placebo-controlled trialFertil Steril772002491498
  • A.E.OmuM.K.Al-AzemiE.O.KehindeJ.T.AnimM.A.OriowoT.C.MathewIndications of the mechanisms involved in improved sperm parameters by zinc therapyMed Princ Pract172008108116
  • A.LenziP.SgròP.SalaconeD.PaoliB.GilioF.Lombardoet alA placebo-controlled double-blind randomized trial of the use of combined l-carnitine and l-acetyl-carnitine treatment in men with asthenozoospermiaFertil Steril81200415781584
  • H.CiftciA.VeritM.SavasE.YeniO.ErelEffects of N-acetylcysteine on semen parameters and oxidative/antioxidant statusUrology7420097376
  • E.GrecoM.IacobelliL.RienziF.UbaldiS.FerreroJ.TesarikReduction of the incidence of sperm DNA fragmentation by oral antioxidant treatmentJ Androl262005349353
  • S.A.SuleimanM.E.AliZ.M.ZakiE.M.el-MalikM.A.NasrLipid peroxidation and human sperm motility: protective role of vitamin EJ Androl171996530537
  • L.Keskes-AmmarN.Feki-ChakrounT.RebaiZ.SahnounH.GhozziS.Hammamiet alSperm oxidative stress and the effect of an oral vitamin E and selenium supplement on semen quality in infertile menArch Androl4920038394
  • K.TremellenG.MiariD.FroilandJ.ThompsonA randomised control trial examining the effect of an antioxidant (Menevit) on pregnancy outcome during IVF-ICSI treatmentAust N Z J Obstet Gynaecol472007216221
  • A.E.OmuH.DashtiS.Al-OthmanTreatment of asthenozoospermia with zinc sulphate: andrological, immunological and obstetric outcomeEur J Obstet Gynecol Reprod Biol791998179184
  • G.CavalliniA.P.FerrarettiL.GianaroliG.BiagiottiG.VitaliCinnoxicam and l-carnitine/acetyl-l-carnitine treatment for idiopathic and varicocele-associated oligoasthenospermiaJ Androl252004761772
  • E.KessopoulouH.J.PowersK.K.SharmaM.J.PearsonJ.M.RussellI.D.Cookeet alA double-blind randomized placebo cross-over controlled trial using the antioxidant vitamin E to treat reactive oxygen species associated male infertilityFertil Steril641995825831
  • W.C.HawkesZ.AlkanK.WongSelenium supplementation does not affect testicular selenium status or semen quality in North American menJ Androl302009525533
  • C.RolfT.G.CooperC.H.YeungE.NieschlagAntioxidant treatment of patients with asthenozoospermia or moderate oligoasthenozoospermia with high-dose vitamin C and vitamin E: a randomized, placebo-controlled, double-blind studyHum Reprod14199910281033
  • M.SigmanS.GlassJ.CampagnoneJ.L.PryorCarnitine for the treatment of idiopathic asthenospermia: a randomized, double-blind, placebo-controlled trialFertil Steril85200614091414
  • F.H.ComhaireA.B.ChristopheA.A.ZalataW.S.DhoogeA.M.MahmoudC.E.DepuydtThe effects of combined conventional treatment, oral antioxidants and essential fatty acids on sperm biology in subfertile menProstaglandins Leukot Essent Fatty Acids632000159165
  • N.P.GuptaR.KumarLycopene therapy in idiopathic male infertility – a preliminary reportInt Urol Nephrol342002369372
  • M.K.MoslemiS.TavanbakhshSelenium-vitamin E supplementation in infertile men: effects on semen parameters and pregnancy rateInt J Gen Med4201199104
  • N.K.MohantyS.KumarA.K.JhaR.P.AroraManagement of idiopathic oligoasthenospermia with lycopeneIndian J Urol1820015761
  • Y.J.MénézoA.HazoutG.PanteixF.RobertJ.RolletP.Cohen-Bacrieet alAntioxidants to reduce sperm DNA fragmentation: an unexpected adverse effectReprod Biomed Online142007418421
  • C.AbadM.J.AmengualJ.GosálvezK.CowardN.HannaouiJ.Benetet alEffects of oral antioxidant treatment upon the dynamics of human sperm DNA fragmentation and subpopulations of sperm with highly degraded DNAAndrologia452013211216
  • J.Gual-FrauC.AbadM.J.AmengualN.HannaouiM.A.ChecaJ.Ribas-Maynouet alOral antioxidant treatment partly improves integrity of human sperm DNA in infertile grade I varicocele patientsHum Fertil (Camb)182015225229
  • E.GevaB.BartoovN.ZabludovskyJ.B.LessingL.Lerner-GevaA.AmitThe effect of antioxidant treatment on human spermatozoa and fertilization rate in an in vitro fertilization programFertil Steril661996430434
  • M.R.SafarinejadThe effect of coenzyme Q(1)(0) supplementation on partner pregnancy rate in infertile men with idiopathic oligoasthenoteratozoospermia: an open-label prospective studyInt Urol Nephrol442012689700
  • E.GrecoS.RomanoM.IacobelliS.FerreroE.BaroniM.G.Minasiet alICSI in cases of sperm DNA damage: beneficial effect of oral antioxidant treatmentHum Reprod20200525902594
  • J.MoilanenO.HovattaExcretion of alpha-tocopherol into human seminal plasma after oral administrationAndrologia271995133136
  • F.SinghA.L.CharlesA.I.SchlagowskiJ.BouitbirA.BonifacioF.Piquardet alReductive stress impairs myoblasts mitochondrial function and triggers mitochondrial hormesisBBA1853201515741585
  • S.MentorD.FisherAggressive antioxidant reductive stress impairs brain endothelial cell angiogenesis and blood brain barrier functionCurr Neurovasc Res1420177181
  • D.LamosováM.JurániM.GreksákM.NakanoM.VanekováEffect of Rooibos tea (Aspalathus linearis) on chick skeletal muscle cell growth in cultureComp Biochem Physiol C: Pharmacol Toxicol Endocrinol11619973945
  • P.ThérondJ.AugerA.LegrandP.JouannetAlpha-tocopherol in human spermatozoa and seminal plasma: relationships with motility, antioxidant enzymes and leukocytesMol Hum Reprod21996739744
  • A.E.OmuT.FatinikunN.MannazhathS.AbrahamSignificance of simultaneous determination of serum and seminal plasma alpha-tocopherol and retinol in infertile men by high-performance liquid chromatographyAndrologia311999347354
  • R.A.JacobF.S.PianaltoR.E.AgeeCellular ascorbate depletion in healthy menJ Nutr122199211111118
  • C.G.FragaP.A.MotchnikM.K.ShigenagaH.J.HelbockR.A.JacobB.N.AmesAscorbic acid protects against endogenous oxidative DNA damage in human spermPNAS8819911100311006
  • S.E.LewisR.John AitkenS.J.ConnerG.D.IuliisD.P.EvensonR.Henkelet alThe impact of sperm DNA damage in assisted conception and beyond: recent advances in diagnosis and treatmentReprod Biomed Online272013325337
  • J.Z.ShiS.S.ZhangZ.ZhangQ.LiangY.ShiJ.L.Huaet alExpressions of sperm-specific genes in carnitine-cultured testis sperm of obstructive azoospermia patientsZhonghua Nan Ke Xue162010504509 [article in Chinese]
  • S.BanihaniA.AgarwalR.SharmaM.BayachouCryoprotective effect of l-carnitine on motility, vitality and DNA oxidation of human spermatozoaAndrologia462014637641
  • I.GülçinAntioxidant and antiradical activities of L-carnitineLife Sci782006803811
  • S.D.AhmedK.A.KariraJagdeshS.AhsanRole of l-carnitine in male infertilityJ Pak Med Assoc612011732736
  • A.LewinH.LavonThe effect of coenzyme Q10 on sperm motility and functionMol Aspects Med18Suppl.1997S213S219
  • A.ManciniB.ConteL.De MarinisM.E.HallgassD.PozzaA.Oradeiet alCoenzyme Q10 levels in human seminal fluid: diagnostic and clinical implicationsMol Aspects Med15Suppl.1994S249S255
  • B.GressierA.CabanisS.LebegueC.BrunetT.DineM.Luyckxet alDecrease of hypochlorous acid and hydroxyl radical generated by stimulated human neutrophils: comparison in vitro of some thiol-containing drugsMethods Find Exp Clin Pharmacol161994913
  • K.ErkkiläV.HirvonenE.WuokkoM.ParvinenL.DunkelN-acetyl-l-cysteine inhibits apoptosis in human male germ cells in vitroJ Clin Endocrinol Metab83199825232531
  • T.OedaR.HenkelH.OhmoriW.B.SchillScavenging effect of N-acetyl-l-cysteine against reactive oxygen species in human semen: a possible therapeutic modality for male factor infertility?Andrologia291997125131
  • A.RoveriA.CasascoM.MaiorinoP.DalanA.CalligaroF.UrsiniPhospholipid hydroperoxide glutathione peroxidase of rat testis. Gonadotropin dependence and immunocytochemical identificationJ Biol Chem267199261426146
  • J.G.AlvarezB.T.StoreyLipid peroxidation and the reactions of superoxide and hydrogen peroxide in mouse spermatozoaBiol Reprod301984833841
  • F.UrsiniS.HeimM.KiessM.MaiorinoA.RoveriJ.Wissinget alDual function of the selenoprotein PHGPx during sperm maturationScience285199913931396
  • G.Noack-FullerC.De BeerH.SeibertCadmium, lead, selenium, and zinc in semen of occupationally unexposed menAndrologia251993712
  • K.M.HambidgeN.F.KrebsZinc deficiency: a special challengeJ Nutr137200711011105
  • S.R.PowellThe antioxidant properties of zincJ Nutr130Suppl.20001447S1454S
  • S.E.ChiaC.N.OngL.H.ChuaL.M.HoS.K.TayComparison of zinc concentrations in blood and seminal plasma and the various sperm parameters between fertile and infertile menJ Androl2120005357
  • R.JoshiS.AdhikariB.S.PatroS.ChattopadhyayT.MukherjeeFree radical scavenging behavior of folic acid: evidence for possible antioxidant activityFree Radic Biol Med30200113901399
  • M.KelkelM.SchumacherM.DicatoM.DiederichAntioxidant and anti-proliferative properties of lycopeneFree Radic Res452011925940
  • A.AgarwalL.H.SekhonOxidative stress and antioxidants for idiopathic oligoasthenoteratospermia: Is it justified?Indian J Urol2720117485
  • T.G.CooperE.NoonanS.von EckardsteinJ.AugerH.W.BakerH.M.Behreet alWorld Health Organization reference values for human semen characteristicsHum Reprod Update162010231245
  • E.B.DawsonW.A.HarrisM.C.TeterL.C.PowellEffect of ascorbic acid supplementation on the sperm quality of smokersFertil Steril58199210341039
  • A.CyrusA.KabirD.GoodarziM.MoghimiThe effect of adjuvant vitamin C after varicocele surgery on sperm quality and quantity in infertile men: a double blind placebo controlled clinical trialInt Braz J Urol412015230238
  • G.BalerciaF.RegoliT.ArmeniA.KoverechF.ManteroM.BoscaroPlacebo-controlled double-blind randomized trial on the use of l-carnitine, l-acetylcarnitine, or combined l-carnitine and l-acetylcarnitine in men with idiopathic asthenozoospermiaFertil Steril842005662671
  • A.NadjarzadehF.ShidfarN.AmirjannatiM.R.VafaS.A.MotevalianM.R.Gohariet alEffect of Coenzyme Q10 supplementation on antioxidant enzymes activity and oxidative stress of seminal plasma: a double-blind randomised clinical trialAndrologia462014177183
  • R.LafuenteM.González-ComadránI.SolàG.LópezM.BrassescoR.Carreraset alCoenzyme Q10 and male infertility: a meta-analysisJ Assist Reprod Genet30201311471156
  • D.VézinaF.MauffetteK.D.RobertsG.BleauSelenium-vitamin E supplementation in infertile men. Effects on semen parameters and micronutrient levels and distributionBiol Trace Elem Res5319966583
  • M.H.HadwaL.A.AlmashhedyA.R.AlsalmanOral zinc supplementation restores superoxide radical scavengers to normal levels in spermatozoa of Iraqi asthenospermic patientsInt J Vitam Nutr Res852015165173
  • A.M.JequierSemen analysis: a new manual and its application to the understanding of semen and its pathologyAsian J Androl1220101113
  • S.C.EstevesClinical relevance of routine semen analysis and controversies surrounding the 2010 World Health Organization criteria for semen examinationInt Braz J Urol402014443453
  • J.ErenpreissM.SpanoJ.ErenpreisaM.BungumA.GiwercmanSperm chromatin structure and male fertility: biological and clinical aspectsAsian J Androl820061129
  • M.B.ShamsiR.KumarR.DadaEvaluation of nuclear DNA damage in human spermatozoa in men opting for assisted reproductionIndian J Med Res1272008115123
  • R.K.SharmaT.SaidA.AgarwalSperm DNA damage and its clinical relevance in assessing reproductive outcomeAsian J Androl62004139148
  • R.A.SalehA.AgarwalR.K.SharmaT.M.SaidS.C.SikkaA.J.ThomasJr.Evaluation of nuclear DNA damage in spermatozoa from infertile men with varicoceleFertil Steril80200314311436
  • R.A.SalehA.AgarwalE.A.NadaM.H.El-TonsyR.K.SharmaA.Meyeret alNegative effects of increased sperm DNA damage in relation to seminal oxidative stress in men with idiopathic and male factor infertilityFertil Steril79Suppl. 3200315971605
  • A.AgarwalC.L.ChoS.C.EstevesShould we evaluate and treat sperm DNA fragmentation?Curr Opin Obstet Gynecol282016164171
  • A.M.Gil-VillaW.Cardona-MayaA.AgarwalR.SharmaA.CadavidRole of male factor in early recurrent embryo loss: do antioxidants have any effect?Fertil Steril922009565571
  • A.AgarwalK.MakkerR.SharmaClinical relevance of oxidative stress in male factor infertility: an updateAm J Reprod Immunol592008211
  • A.AgarwalE.TvrdaR.SharmaRelationship amongst teratozoospermia, seminal oxidative stress and male infertilityReprod Biol Endocrinol12201445
  • M.CocuzzaS.C.SikkaK.S.AthaydeA.AgarwalClinical relevance of oxidative stress and sperm chromatin damage in male infertility: an evidence based analysisInt Braz J Urol332007603621
  • P.GharagozlooR.J.AitkenThe role of sperm oxidative stress in male infertility and the significance of oral antioxidant therapyHum Reprod26201116281640
  • M.E.HammadehS.Al HasaniP.RosenbaumW.SchmidtC.Fischer HammadehReactive oxygen species, total antioxidant concentration of seminal plasma and their effect on sperm parameters and outcome of IVF/ICSI patientsArch Gynecol Obstet2772008515526
  • M.G.ShowellR.Mackenzie-ProctorJ.BrownA.YazdaniM.T.StankiewiczR.J.HartAntioxidants for male subfertilityCochrane Database Syst Rev122014CD00741110.1002/14651858.CD007411
  • C.RossA.MorrissM.KhairyY.KhalafP.BraudeA.Coomarasamyet alA systematic review of the effect of oral antioxidants on male infertilityReprod Biomed Online202010711723