- Jabes D. The antibiotic R&D pipeline: an update. Curr Opin Microbiol2011; 14: 564–569.
- Schultz C, Geerlings S. Plasmid-mediated resistance in Enterobacteriaceae: changing landscape and implications for therapy. Drugs2012; 72: 1–16.
- Martinez M, Silley P. Antimicrobial drug resistance. Handb Exp Pharmacol2010; 199: 227–264.
- Zhang Y, Heym B, Allen B et al. The catalase-peroxidase gene and isoniazid resistance of Mycobacterium tuberculosis. Nature1992; 358: 591–593.
- Scorpio A, Zhang Y. Mutations in pncA, a gene encoding pyrazinamidase/nicotinamidase, causes resistance to antituberculous drug pyrazinamide in tubercle Bacillus. Nature Medicine1996; 2: 662–667.
- Goodwin A, Kersulyte D, Sisson G et al. Metronidazole resistance in Helicobacter pylori is due to null mutations in a gene (rdxA) that encodes an oxygen-insensitive NADPH nitroreductase. Mol Microbiol1998; 28: 383–393.
- Theuretzbacher U. Resistance drives antibacterial drug development. Curr Opin Pharmacol2011; 11: 433–438.
- Kohanski MA, Dwyer DJ, Collins JJ. How antibiotics kill bacteria: from targets to networks. Nature Rev Microbiol2010; 8: 423–435.
- Fischbach MA. Combination therapies for combating antimicrobial resistance. Curr Opin Microbiol2011; 14: 519–523.
- Roemer T, Davies J, Giaever G et al. Bugs, drugs and chemical genomics. Nat Chem Biol2011; 8: 46–56.
- Bassetti M, Ginocchio F, Mikulska M et al. Will new antimicrobials overcome resistance among Gram-negatives? Expert Rev Anti Infect Ther2011; 9: 909–922.
- Ma Q, Yu Z, Han B et al. [Research progress in fusion expression of antimicrobial peptides.] Sheng Wu Gong Cheng Xue Bao2011; 27: 1408–1416. Chinese.
- Pucci MJ. Novel genetic techniques and approaches in the microbial genomics era: identification and/or validation of targets for the discovery of new antibacterial agents. Drugs RD2007; 8: 201–212.
- Manai M, Cozzone AJ. Analysis of the protein kinase activity of Escherichia coli cells. Biochem Biophys Res Commun1979; 91: 819–826.
- Wang JH, Koshland DE Jr. Evidence for protein kinase activities in the prokaryote Salmonella typhimurium. J Biol Chem1978; 253: 7605–7608.
- Pereira SFF, Goss L, Dworkin J. Eukaryote-like serine/threonine kinases and phosphatases in bacteria. Microbiol Molec Bio Rev2011; 75: 192–212.
- Grangeasse C, Cozzone AJ, Deutscher J et al. Tyrosine phosphorylation: an emerging device of bacterial physiology. Trends Biochem Sci2007; 32: 86–94.
- Mijakovic I, Macek B. Impact of phosphoproteomics on studies of bacterial physiology. FEMS Microbiol Rev2012; 36: 877–892.
- Lengeler JW, Jahreis K. Bacterial PEP-dependent carbohydrate: phosphotransferase systems couple sensing and global control mechanisms. Contrib Microbiol2009; 16: 65–87.
- Goulian M. Two-component signaling circuit structure and properties. Curr Opin Microbiol2010; 13: 184–189.
- Ge R, Shan W. Bacterial phosphoproteomic analysis reveals the correlation between protein phosphorylation and bacterial pathogenicity. Genom Proteom Bioinform2011; 9: 119–127.
- Scherr N, Honnappa S, Kunz G et al. Structural basis for the specific inhibition of protein kinase G, a virulence factor of Mycobacterium tuberculosis. Proc Natl Acad Sci USA2007; 104: 12151–12156.
- Grangeasse C, Nessler S, Morera S et al. Inhibitors of bacterial tyrosine kinase and uses thereof. World Intellectual Property Organization. WO/2009/133209A1, 2009
- Stephenson K, Hoch JA. Two-component and phosphorelay signal-transduction systems as therapeutic targets. Curr Opin Pharmacol2002; 2: 507–512.
- Rasko DA, Moreira CG, Li DR et al. Targeting QseC signaling and virulence for antibiotic development. Science2008; 321: 1078–1080.
- Li N, Wang F, Niu S et al. Discovery of novel inhibitors of Streptococcus pneumoniae based on the virtual screening with the homology-modeled structure of histidine kinase VicK. BMC Microbiol2009; 9: 129–139.
- Debarbouillé M, Dramsi S, Dussurget O et al. Characterization of a serine/threonine kinase involved in virulence of Staphylococcus aureus. J Bacteriol2009; 191: 4070–4081.
- Olivares-Illana V, Meyer P, Bechet E et al. Structural basis for the regulation mechanism of the tyrosine kinase CapB from Staphylococcus aureus. PLoS Biol2008; 6: e143.
- Lee DC, Zheng J, She YM et al. Structure of Escherichia coli tyrosine kinase Etk reveals a novel activation mechanism. EMBO J2008; 27: 1758–1766.
- Bechet E, Gruszczyk J, Terreux R et al. Identification of structural and molecular determinants of the tyrosine kinase Wzc and implications in capsular polysaccharide export. Molec Microbiol2010; 77: 1315–1325.
Open access
453
Views
11
CrossRef citations to date
0
Altmetric
Commentaries
An insight into future antibacterial therapy
Alain J CozzoneInstitute of Biology and Chemistry of Proteins, University of Lyon, 7 passage du Vercors, 69007 Lyon, France
Pages 1-3
|
Received 28 May 2012, Accepted 17 Sep 2012, Published online: 25 Jan 2019
Related research
People also read lists articles that other readers of this article have read.
Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.
Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.