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Emerging Microbes & Infections Volume 4, 2015 - Issue 1
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Original Articles

T-cell reprogramming through targeted CD4-coreceptor and T-cell receptor expression on maturing thymocytes by latent Circoviridae family member porcine circovirus type 2 cell infections in the thymus

Stefanie Klausmann Institute of Veterinary Pathology, Vetsuisse Faculty, University of Zurich , CH-8057 Zurich, Switzerland; Department of Farm Animals, Division of Swine Medicine, Vetsuisse Faculty, University of Zurich , CH-8057-Zurich, Switzerland
,
Titus Sydler Institute of Veterinary Pathology, Vetsuisse Faculty, University of Zurich , CH-8057 Zurich, Switzerland
,
Summerfield Artur Institute of Virology and Immunology (IVI) , 3147 Mittelhäusern, Switzerland
,
Fraser I Lewis Section of Epidemiology, Vetsuisse Faculty, University of Zurich , CH-8057 Zurich, Switzerland
,
Roseline Weilenmann Institute of Veterinary Pathology, Vetsuisse Faculty, University of Zurich , CH-8057 Zurich, Switzerland
,
Xaver Sidler Department of Farm Animals, Division of Swine Medicine, Vetsuisse Faculty, University of Zurich , CH-8057-Zurich, Switzerland
&
Enrico Brugnera Institute of Veterinary Pathology, Vetsuisse Faculty, University of Zurich , CH-8057 Zurich, Switzerland; Department of Farm Animals, Division of Swine Medicine, Vetsuisse Faculty, University of Zurich , CH-8057-Zurich, SwitzerlandCorrespondence[email protected]
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Pages 1-12 | Received 02 Jul 2014, Accepted 31 Jan 2015, Published online: 25 Jan 2019

  • Stone JD , Chervin AS , Kranz DM .T-cell receptor binding affinities and kinetics: impact on T-cell activity and specificity. Immunology 2009;126: 165–176.
  • Starr TK , Jameson SC , Hogquist KA .Positive and negative selection of T cells. Annu Rev Immunol 2003;21: 139–176.
  • Klein L , Kyewski B , Allen PM , Hogquist KA .Positive and negative selection of the T cell repertoire: what thymocytes see (and don't see). Nat Rev Immunol 2014;14: 377–391.
  • Brugnera E , Bhandoola A , Cibotti R et al.Coreceptor reversal in the thymus: signaled CD4+8+ thymocytes initially terminate CD8 transcription even when differentiating into CD8+ T cells. Immunity 2000;13: 59–71.
  • Singer A , Adoro S , Park JH .Lineage fate and intense debate: myths, models and mechanisms of CD4- versus CD8-lineage choice. Nat Rev Immunol 2008;8: 788–801.
  • Takada K , Jameson SC .Naive T cell homeostasis: from awareness of space to a sense of place. Nat Rev Immunol 2009;9: 823–832.
  • Fathman CG , Lineberry NB .Molecular mechanisms of CD4+ T-cell anergy. Nat Rev Immunol 2007;7: 599–609.
  • Kaiser P .Advances in avian immunology — prospects for disease control: a review. Avian Pathol 2010;39: 309–324.
  • Li L , Kapoor A , Slikas B et al.Multiple diverse circoviruses infect farm animals and are commonly found in human and chimpanzee feces. J Virol 2010;84: 1674–1682.
  • Bendinelli M , Pistello M , Maggi F , Fornai C , Freer G , Vatteroni ML .Molecular properties, biology, and clinical implications of TT virus, a recently identified widespread infectious agent of humans. Clin Microbiol Rev 2001;14: 98–113.
  • Li L , Shan T , Soji OB et al.Possible cross-species transmission of circoviruses and cycloviruses among farm animals. J Gen Virol 2011;92: 768–772.
  • Macera L , Cortey M , Maggi F , Segales J , Kekarainen T .A novel rolling circle amplification assay to detect members of the family Anelloviridae in pigs and humans. Virus Res 2011;160: 424–427.
  • Biagini P , Bedarida S , Touinssi M , Galicher V , de Micco P .Human gyrovirus in healthy blood donors, France. Emerg Infect Dis 2013;19: 1014–1015.
  • Maggi F , Macera L , Focosi D et al.Human gyrovirus DNA in human blood, Italy. Emerg Infect Dis 2012;18: 956–959.
  • Tan le V , van Doorn HR , Nghia HD et al.Identification of a new cyclovirus in cerebrospinal fluid of patients with acute central nervous system infections. MBio 2013;4: e00231–e00213.
  • Kekarainen T , Sibila M , Segales J .Prevalence of swine Torque teno virus in post-weaning multisystemic wasting syndrome (PMWS)-affected and non-PMWS-affected pigs in Spain. J Gen Virol 2006;87: 833–837.
  • Ritterbusch GA , Rocha CA , Mores N et al.Natural co-infection of torque teno virus and porcine circovirus 2 in the reproductive apparatus of swine. Res Vet Sci 2012;92: 519–523.
  • Ellis JA , Allan G , Krakowka S .Effect of coinfection with genogroup 1 porcine torque teno virus on porcine circovirus type 2-associated postweaning multisystemic wasting syndrome in gnotobiotic pigs. Am J Vet Res 2008;69: 1608–1614.
  • Smits SL , Zijlstra EE , van Hellemond JJ et al.Novel cyclovirus in human cerebrospinal fluid, Malawi, 2010–2011. Emerg Infect Dis 2013;19. doi: https://doi.org/10.3201/eid1909.130404.
  • Gia Phan T , Phung Vo N , Sdiri-Loulizi K et al.Divergent gyroviruses in the feces of Tunisian children. Virology 2013;446: 346–348.
  • Allan GM , Ellis JA .Porcine circoviruses: a review. J Vet Diagn Invest 2000;12: 3–14.
  • Nayabian H , Mardani K .Molecular characterization of the chicken anaemia viruses isolated from broiler farms of west Azerbaijan, Iran. Avian Pathol 2013;42: 108–113.
  • Ellis J , Clark E , Haines D et al.Porcine circovirus-2 and concurrent infections in the field. Vet Microbiol 2004;98: 159–163.
  • Faurez F , Dory D , Grasland B , Jestin A .Replication of porcine circoviruses. Virol J 2009;6: 60.
  • Steinfeldt T , Finsterbusch T , Mankertz A .Demonstration of nicking/joining activity at the origin of DNA replication associated with the rep and rep' proteins of porcine circovirus type 1. J Virol 2006;80: 6225–6234.
  • Segales J , Kekarainen T , Cortey M .The natural history of porcine circovirus type 2: from an inoffensive virus to a devastating swine disease? Vet Microbiol 2013;165: 13–20.
  • Cheung AK , Lager KM , Kohutyuk OI et al.Detection of two porcine circovirus type 2 genotypic groups in United States swine herds. Arch Virol 2007;152: 1035–1044.
  • Segales J , Olvera A , Grau-Roma L et al.PCV-2 genotype definition and nomenclature. Vet Rec 2008;162: 867–868.
  • Tomas A , Fernandes LT , Valero O , Segales J .A meta-analysis on experimental infections with porcine circovirus type 2 (PCV2). Vet Microbiol 2008;132: 260–273.
  • Baumgartner M , Brugnera E , Sydler T , Burgi E , Hassig M , Sidler X .Risk factors causing postweaning multisystemic wasting syndrome (PMWS) onset in Swiss pig farms. Schweiz Arch Tierheilkd 2012;154: 429–436.
  • Opriessnig T , Meng XJ , Halbur PG .Porcine circovirus type 2 associated disease: update on current terminology, clinical manifestations, pathogenesis, diagnosis, and intervention strategies. J Vet Diagn Invest 2007;19: 591–615.
  • Harding JC , Ellis JA , McIntosh KA , Krakowka S .Dual heterologous porcine circovirus genogroup 2a/2b infection induces severe disease in germ-free pigs. Vet Microbiol 2010;145: 209–219.
  • Khaiseb S , Sydler T , Zimmermann D , Pospischil A , Sidler X , Brugnera E .Coreplication of the major genotype group members of porcine circovirus type 2 as a prerequisite to coevolution may explain the variable disease manifestations. J Virol 2011;85: 11111–11120.
  • Segales J .Porcine circovirus type 2 (PCV2) infections: clinical signs, pathology and laboratory diagnosis. Virus Res 2012;164: 10–19.
  • Opriessnig T , Meng XJ , Halbur PG .Porcine circovirus type 2 associated disease: update on current terminology, clinical manifestations, pathogenesis, diagnosis, and intervention strategies. J Vet Diagn Invest 2007;19: 591–615.
  • Wiederkehr DD , Sydler T , Buergi E et al.A new emerging genotype subgroup within PCV-2b dominates the PMWS epizooty in Switzerland. Vet Microbiol 2009;136: 27–35.
  • Segales J , Allan GM , Domingo M .Porcine circovirus diseases. Anim Health Res Rev 2005;6: 119–142.
  • Darwich L , Segales J , Domingo M , Mateu E .Changes in CD4+, CD8+, CD4+ CD8+, and immunoglobulin M-positive peripheral blood mononuclear cells of postweaning multisystemic wasting syndrome-affected pigs and age-matched uninfected wasted and healthy pigs correlate with lesions and porcine circovirus type 2 load in lymphoid tissues. Clin Diagn Lab Immunol 2002;9: 236–242.
  • Darwich L , Balasch M , Plana-Duran J , Segales J , Domingo M , Mateu E .Cytokine profiles of peripheral blood mononuclear cells from pigs with postweaning multisystemic wasting syndrome in response to mitogen, superantigen or recall viral antigens. J Gen Virol 2003;84: 3453–3457.
  • Sundt TM , LeGuern C , Germana S et al.Characterization of a polymorphism of CD4 in miniature swine. J Immunol 1992;148: 3195–3201.
  • Frey CF , Bauhofer O , Ruggli N , Summerfield A , Hofmann MA , Tratschin JD .Classical swine fever virus replicon particles lacking the Erns gene: a potential marker vaccine for intradermal application. Vet Res 2006;37: 655–670.
  • Kurmann J , Sydler T , Brugnera E et al.Vaccination of dams increases antibody titer and improves growth parameters in finisher pigs subclinically infected with porcine circovirus type 2. Clin Vaccine Immunol 2011;18: 1644–1649.
  • Sun X , Wertz N , Lager KM , Butler JE .Antibody repertoire development in fetal and neonatal piglets. XV. Porcine circovirus type 2 infection differentially affects serum IgG levels and antibodies to ORF2 in piglets free from other environmental factors. Vaccine 2012;31: 141–148.
  • Lang PA , Recher M , Haussinger D , Lang KS .Genes determining the course of virus persistence in the liver: lessons from murine infection with lymphocytic choriomeningitis virus. Cell Physiol Biochem 2010;26: 263–272.
  • Meerts P , Misinzo G , Lefebvre D et al.Correlation between the presence of neutralizing antibodies against porcine circovirus 2 (PCV2) and protection against replication of the virus and development of PCV2-associated disease. BMC Vet Res 2006;2: 6.
  • Fort M , Olvera A , Sibila M , Segales J , Mateu E .Detection of neutralizing antibodies in postweaning multisystemic wasting syndrome (PMWS)-affected and non-PMWS-affected pigs. Vet Microbiol 2007;125: 244–255.
  • Lunney JK , Ho CS , Wysocki M , Smith DM .Molecular genetics of the swine major histocompatibility complex, the SLA complex. Dev Comp Immunol 2009;33: 362–374.
  • Schindler M , Munch J , Kutsch O et al.Nef-mediated suppression of T cell activation was lost in a lentiviral lineage that gave rise to HIV-1. Cell 2006;125: 1055–1067.
  • Dembic Z , Munthe LA , Schenck K , Mueller C , Bogen B .Transient overexpression of CD4 enhances allelic exclusion of T-cell receptor (TCR) alpha chains and promotes positive selection of class II-restricted TCR-transgenic thymocytes. Mol Immunol 1998;35: 23–38.
  • Sarafova SD , van Laethem F , Adoro S et al.Upregulation of CD4 expression during MHC class II-specific positive selection is essential for error-free lineage choice. Immunity 2009;31: 480–490.
  • Welch J , Bienek C , Gomperts E , Simmonds P .Resistance of porcine circovirus and chicken anemia virus to virus inactivation procedures used for blood products. Transfusion 2006;46: 1951–1958.
  • Morris GP , Allen PM .How the TCR balances sensitivity and specificity for the recognition of self and pathogens. Nat Immunol 2012;13: 121–128.
  • Tikhonova AN , Van Laethem F , Hanada K et al.alphabeta T cell receptors that do not undergo major histocompatibility complex-specific thymic selection possess antibody-like recognition specificities. Immunity 2012;36: 79–91.
  • Naeher D , Daniels MA , Hausmann B , Guillaume P , Luescher I , Palmer E .A constant affinity threshold for T cell tolerance. J Exp Med 2007;204: 2553–2559.
  • Gelderblom H , Kling S , Lurz R , Tischer I , von Bulow V .Morphological characterization of chicken anaemia agent (CAA). Arch Virol 1989;109: 115–120.
  • Vaziry A , Silim A , Bleau C , Frenette D , Lamontagne L .Chicken infectious anaemia vaccinal strain persists in the spleen and thymus of young chicks and induces thymic lymphoid cell disorders. Avian Pathol 2011;40: 377–385.
  • Jeurissen SH , Wagenaar F , Pol JM , van der Eb AJ , Noteborn MH .Chicken anemia virus causes apoptosis of thymocytes after in vivo infection and of cell lines after in vitro infection. J Virol 1992;66: 7383–7388.

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