Advanced search
Publication Cover
Emerging Microbes & Infections Volume 4, 2015 - Issue 1
Submit an article Journal homepage
675
Views
16
CrossRef citations to date
0
Altmetric
Original Articles

An H5N1-based matrix protein 2 ectodomain tetrameric peptide vaccine provides cross-protection against lethal infection with H7N9 influenza virus

Ho-Chuen LeungDepartment of Microbiology, University of Hong Kong, Hong Kong, China
,
Chris Chung-Sing ChanDepartment of Microbiology, University of Hong Kong, Hong Kong, China
,
Vincent Kwok-Man PoonDepartment of Microbiology, University of Hong Kong, Hong Kong, China
,
Han-Jun ZhaoDepartment of Microbiology, University of Hong Kong, Hong Kong, China
,
Chung-Yan CheungDepartment of Microbiology, University of Hong Kong, Hong Kong, China
,
Fai NgDepartment of Microbiology, University of Hong Kong, Hong Kong, China
,
Jian-Dong HuangDepartment of Microbiology, University of Hong Kong, Hong Kong, China
&
Bo-Jian ZhengDepartment of Microbiology, University of Hong Kong, Hong Kong, China
 show all
Pages 1-7 | Received 01 Feb 2015, Accepted 01 Mar 2015, Published online: 25 Jan 2019

  • European Center For Disease Prevention and Control. Communicable disease threats report, week 50, 7–13 December 2014.Stockholm: ECDC, 2014.Available at http://www.ecdc.europa.eu/en/publications/Publications/communicable-disease-threats-report-13-dec-2014.pdf
  • World Health Organization. Background and summary of human infection with avian influenza A(H7N9) virus – as of 31 January 2014.Geneva: WHO, 2014.Available at http://www.who.int/influenza/human_animal_interface/20140131_background_and_summary_H7N9_v1.pdf?ua=1
  • Zhou J, Wang D, Gao R et al.Biological features of novel avian influenza A (H7N9) virus. Nature 2013;499: 500–503.
  • Gao R, Cao B, Hu Y et al.Human infection with a novel avian-origin influenza A (H7N9) virus. N Engl J Med 2013;368: 1888–1897.
  • Subbarao EK, London W, Murphy BR.A single amino acid in the PB2 gene of influenza A virus is a determinant of host range. J Virol 1993;67: 1761–1764.
  • Lam TT, Wang J, Shen Y et al.The genesis and source of the H7N9 influenza viruses causing human infections in China. Nature 2013;502: 241–244.
  • Cowling BJ, Jin L, Lau EH et al.Comparative epidemiology of human infections with avian influenza A H7N9 and H5N1 viruses in China: a population-based study of laboratory-confirmed cases. Lancet 2013;382: 129–137.
  • Gao HN, Lu HZ, Cao B et al.Clinical findings in 111 cases of influenza A (H7N9) virus infection. N Engl J Med 2013;368: 2277–2285.
  • Centers for Disease Control and Prevention (CDC).Emergence of avian influenza A(H7N9) virus causing severe human illness – China, February–April 2013. MMWR Morb Mortal Wkly Rep 2013;62: 366–371.
  • Hu Y, Lu S, Song Z et al.Association between adverse clinical outcome in human disease caused by novel influenza A H7N9 virus and sustained viral shedding and emergence of antiviral resistance. Lancet 2013;381: 2273–2279.
  • Klausberger M, Wilde M, Palmberger D et al.One-shot vaccination with an insect cell-derived low-dose influenza A H7 virus-like particle preparation protects mice against H7N9 challenge. Vaccine 2014;32: 355–362.
  • Fiers W, De Filette M, Birkett A et al.A “universal” human influenza A vaccine. Virus Res 2004;103: 173–176.
  • Liu W, Zou P, Ding J et al.Sequence comparison between the extracellular domain of M2 protein human and avian influenza A virus provides new information for bivalent influenza vaccine design. Microbes Infect 2005;7: 171–177.
  • Hemmatzadeh F, Sumarningsih S, Tarigan S et al.Recombinant M2e protein-based ELISA: a novel and inexpensive approach for differentiating avian influenza infected chickens from vaccinated ones. PLoS ONE 2013;8: e56801.
  • Huleatt JW, Nakaar V, Desai P et al.Potent immunogenicity and efficacy of a universal influenza vaccine candidate comprising a recombinant fusion protein linking influenza M2e to the TLR5 ligand flagellin. Vaccine 2008;26: 201–214.
  • Neirynck S, Deroo T, Saelens X et al.A universal influenza A vaccine based on the extracellular domain of the M2 protein. Nat Med 1999;5: 1157–1163.
  • Zhao G, Du L, Xiao W et al.Induction of protection against divergent H5N1 influenza viruses using a recombinant fusion protein linking influenza M2e to Onchocerca volvulus activation associated protein-1 (ASP-1) adjuvant. Vaccine 2010;28: 7233–7240.
  • De Filette M, Martens W, Roose K et al.An influenza A vaccine based on tetrameric ectodomain of matrix protein 2. J Biol Chem 2008;283: 11382–11387.
  • Tompkins SM, Zhao ZS, Lo CY et al.Matrix protein 2 vaccination and protection against influenza viruses, including subtype H5N1. Emerg Infect Dis 2007;13: 426–435.
  • Zhao G, Lin Y, Du L et al.An M2e-based multiple antigenic peptide vaccine protects mice from lethal challenge with divergent H5N1 influenza viruses. Virol J 2010;7: 9.
  • Zhao G, Sun S, Du L et al.An H5N1 M2e-based multiple antigenic peptide vaccine confers heterosubtypic protection from lethal infection with pandemic 2009 H1N1 virus. Virol J 2010;7: 151.
  • Zheng BJ, Chan KW, Lin YP et al.Delayed antiviral plus immunomodulator treatment still reduces mortality in mice infected by high inoculum of influenza A/H5N1 virus. Proc Natl Acad Sci USA 2008;105: 8091–8096.
  • Du L, Leung VH, Zhang X et al.A recombinant vaccine of H5N1 HA1 fused with foldon and human IgG Fc induced complete cross-clade protection against divergent H5N1 viruses. PLoS ONE 2011;6: e16555.
  • Du L, Zhao G, He Y et al.Receptor-binding domain of SARS-CoV spike protein induces long-term protective immunity in an animal model. Vaccine 2007;25: 2832–2838.
  • Du L, Zhao G, Lin Y et al.Intranasal vaccination of recombinant adeno-associated virus encoding receptor-binding domain of severe acute respiratory syndrome coronavirus (SARS-CoV) spike protein induces strong mucosal immune responses and provides long-term protection against SARS-CoV infection. J Immunol 2008;180: 948–956.
  • Thevenet P, Shen Y, Maupetit J et al.PEP-FOLD: an updated de novo structure prediction server for both linear and disulfide bonded cyclic peptides. Nucleic Acids Res 2012;40: W288–W293.
  • Maupetit J, Derreumaux P, Tuffery P.PEP-FOLD: an online resource for de novo peptide structure prediction. Nucleic Acids Res 2009;37: W498–W503.
  • Maupetit J, Derreumaux P, Tuffery P.A fast method for large-scale de novo peptide and miniprotein structure prediction. J Comput Chem 2010;31: 726–738.
  • Bommakanti G, Citron MP, Hepler RW et al.Design of an HA2-based Escherichia coli expressed influenza immunogen that protects mice from pathogenic challenge. Proc Natl Acad Sci USA 2010;107: 13701–13706.
  • Quan FS, Kim MC, Lee BJ et al.Influenza M1 VLPs containing neuraminidase induce heterosubtypic cross-protection. Virology 2012;430: 127–135.
  • Kim EH, Lee JH, Pascua PN et al.Prokaryote-expressed M2e protein improves H9N2 influenza vaccine efficacy and protection against lethal influenza A virus in mice. Virol J 2013;10: 104.
  • Liu W, Zou P, Ding J et al.Sequence comparison between the extracellular domain of M2 protein human and avian influenza A virus provides new information for bivalent influenza vaccine design. Microbes Infect 2005;7: 171–177.
  • Zharikova D, Mozdzanowska K, Feng J et al.Influenza type A virus escape mutants emerge in vivo in the presence of antibodies to the ectodomain of matrix protein 2. J Virol 2005;79: 6644–6654.
  • Xu L, He D, Li Z et al.Protection against lethal enterovirus 71 challenge in mice by a recombinant vaccine candidate containing a broadly cross-neutralizing epitope within the VP2 EF loop. Theranostics 2014;4: 498–513.
  • Wu CN, Lin YC, Fann C et al.Protection against lethal enterovirus 71 infection in newborn mice by passive immunization with subunit VP1 vaccines and inactivated virus. Vaccine 2001;20: 895–904.
  • Billiau A, Matthys P.Modes of action of Freund's adjuvants in experimental models of autoimmune diseases. J Leukoc Biol 2001;70: 849–860.
  • Wu F, Yuan XY, Huang WS et al.Heterosubtypic protection conferred by combined vaccination with M2e peptide and split influenza vaccine. Vaccine 2009;27: 6095–6101.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.