1,207
Views
17
CrossRef citations to date
0
Altmetric
Original Articles

Endogenous nitric oxide accumulation is involved in the antifungal activity of Shikonin against Candida albicans

, , , , &
Pages 1-6 | Received 26 Aug 2015, Accepted 22 Mar 2016, Published online: 25 Jan 2019

  • KimJ,SudberyP.Candida albicans, a major human fungal pathogen.J Microbiol2011; 49:171–177.
  • OddsFC,BrownAJ,GowNA.Antifungal agents: mechanisms of action.Trends Microbiol2003; 11:272–279.
  • WarrilowAG,MartelCM,ParkerJEet al.Azole binding properties of Candida albicans sterol 14-alpha demethylase (CaCYP51).Antimicrob Agents Chemother2010; 54:4235–4245.
  • SucherAJ,ChahineEB,BalcerHE.Echinocandins: the newest class of antifungals.Ann Pharmacother2009; 43:1647–1657.
  • EllisD.Amphotericin B: spectrum and resistance.J Antimicrob Chemother2002; 49:7–10.
  • GhannoumMA,RiceLB.Antifungal agents: mode of action, mechanisms of resistance, and correlation of these mechanisms with bacterial resistance.Clin Microbiol Rev1999; 12:501–517.
  • AkinsRA.An update on antifungal targets and mechanisms of resistance in Candida albicans.Med Mycol2005; 43:285–318.
  • MartinsCV,da SilvaDL,NeresATet al.Curcumin as a promising antifungal of clinical interest.J Antimicrob Chemother2009; 63:337–339.
  • SasakiK,AbeH,YoshizakiF.In vitro antifungal activity of naphthoquinone derivatives.Biol Pharm Bull2002; 25:669–670.
  • LeeMJ,KaoSH,HunagJEet al.Shikonin time-dependently induced necrosis or apoptosis in gastric cancer cells via generation of reactive oxygen species.Chem Biol Interact2014; 211:44–53.
  • NamKN,SonMS,ParkJHet al.Shikonins attenuate microglial inflammatory responses by inhibition of ERK, Akt, and NF-kappaB: neuroprotective implications.Neuropharmacology2008; 55:819–825.
  • MiaoH,ZhaoL,LiCet al.Inhibitory effect of Shikonin on Candida albicans growth.Biol Pharm Bull2012; 35:1956–1963.
  • UllmannBD,MyersH,ChiranandWet al.Inducible defense mechanism against nitric oxide in Candida albicans.Eukaryot Cell2004; 3:715–723.
  • ZemkeAC,ShivaS,BurnsJLet al.Nitrite modulates bacterial antibiotic susceptibility and biofilm formation in association with airway epithelial cells.Free Radic Biol Med2014; 77:307–316.
  • FriedmanAJ,BlecherK,SchairerDet al.Improved antimicrobial efficacy with nitric oxide releasing nanoparticle generated S-nitrosoglutathione.Nitric Oxide2011; 25:381–386.
  • HaqueSS.Impact of nitric oxide precursor L-arginine on oxidative stress against typhoid.Bratisl Lek Listy2012; 113:589–591.
  • LeitchGJ,HeQ.Arginine-derived nitric oxide reduces fecal oocyst shedding in nude mice infected with Cryptosporidium parvum.Infect Immun1994; 62:5173–5176.
  • HeilmanBJ,TadleAC,PimentelLRet al.Selective damage to hyphal form through light-induced delivery of nitric oxide to Candida albicans colonies.J Inorg Biochem2013; 123:18–22.
  • HromatkaBS,NobleSM,JohnsonAD.Transcriptional response of Candida albicans to nitric oxide and the role of the YHB1 gene in nitrosative stress and virulence.Mol Biol Cell2005; 16:4814–4826.
  • ChiranandW,McLeodI,ZhouHet al.CTA4 transcription factor mediates induction of nitrosative stress response in Candida albicans.Eukaryot Cell2008; 7:268–278.
  • FonziWA,IrwinMY.Isogenic strain construction and gene mapping in Candida albicans.Genetics1993; 134:717–728.
  • NobleSM,FrenchS,KohnLAet al.Systematic screens of a Candida albicans homozygous deletion library decouple morphogenetic switching and pathogenicity.Nat Genet2010; 42:590–598.
  • CostaAC,de Campos RasteiroVM,PereiraCAet al.Susceptibility of Candida albicans and Candida dubliniensis to erythrosine- and LED-mediated photodynamic therapy.Arch Oral Biol2011; 56:1299–1305.
  • CaoY,ZhuZ,ChenXet al.Effect of amphotericin B on the metabolic profiles of Candida albicans.J Proteome Res2013; 12:2921–2932.
  • KaganS,JabbourA,SionovEet al.Anti-Candida albicans biofilm effect of novel heterocyclic compounds.J Antimicrob Chemother2014; 69:416–427.
  • VincentBM,LancasterAK,Scherz-ShouvalRet al.Fitness trade-offs restrict the evolution of resistance to amphotericin B.PLoS Biol2013; 11:e1001692.
  • FangFC.Antimicrobial reactive oxygen and nitrogen species: concepts and controversies.Nat Rev Microbiol2004; 2:820–832.
  • MacherlaC,SanchezDA,AhmadiMSet al.Nitric oxide releasing nanoparticles for treatment of Candida albicans burn infections.Front Microbiol2012; 3:193.
  • AranaDM,NombelaC,PlaJ.Fluconazole at subinhibitory concentrations induces the oxidative- and nitrosative-responsive genes TRR1, GRE2 and YHB1, and enhances the resistance of Candida albicans to phagocytes.J Antimicrob Chemother2010; 65:54–62.
  • TillmannA,GowNA,BrownAJ.Nitric oxide and nitrosative stress tolerance in yeast.Biochem Soc Trans2011; 39:219–223.
  • HelmickRA,FletcherAE,GardnerAMet al.Imidazole antibiotics inhibit the nitric oxide dioxygenase function of microbial flavohemoglobin.Antimicrob Agents Chemother2005; 49:1837–1843.
  • SellamA,TebbjiF,WhitewayMet al.A novel role for the transcription factor Cwt1p as a negative regulator of nitrosative stress in Candida albicans.PLoS One2012; 7:e43956.