Zika virus infects renal proximal tubular epithelial cells with prolonged persistency and cytopathic effects

References

• Duffy MR, Chen TH, Hancock WTet al.Zika virus outbreak on Yap Island, Federated States of Micronesia. N Engl J Med 2009;360: 2536–2543.
   PubMed Web of Science ®Google Scholar
• Brasil P, Pereira JP Jr, Moreira MEet al.Zika virus infection in pregnant women in Rio de Janeiro. N Engl J Med 2016;375: 2321–2334.
   PubMed Web of Science ®Google Scholar
• Wu KY, Zuo GL, Li XFet al.Vertical transmission of Zika virus targeting the radial glial cells affects cortex development of offspring mice. Cell Res 2016;26: 645–654.
   PubMed Web of Science ®Google Scholar
• Miner JJ, Cao B, Govero Jet al.Zika virus infection during pregnancy in mice causes placental damage and fetal demise. Cell 2016;165: 1081–1091.
   PubMed Web of Science ®Google Scholar
• Cugola FR, Fernandes IR, Russo FBet al.The Brazilian Zika virus strain causes birth defects in experimental models. Nature 2016;534: 267–271.
   PubMed Web of Science ®Google Scholar
• Li C, Xu D, Ye Qet al.Zika virus disrupts neural progenitor development and leads to microcephaly in mice. Cell Stem Cell 2016;19: 120–126.
   PubMed Web of Science ®Google Scholar
• Adams Waldorf KM, Stencel-Baerenwald JE, Kapur RPet al.Fetal brain lesions after subcutaneous inoculation of Zika virus in a pregnant nonhuman primate. Nat Med 2016;22: 1256–1259.
   PubMed Web of Science ®Google Scholar
• Tang H, Hammack C, Ogden SCet al.Zika virus infects human cortical neural progenitors and attenuates their growth. Cell Stem Cell 2016;18: 587–590.
   PubMed Web of Science ®Google Scholar
• Hanners NW, Eitson JL, Usui Net al.Western Zika virus in human fetal neural progenitors persists long term with partial cytopathic and limited immunogenic effects. Cell Rep 2016;15: 2315–2322.
   PubMed Web of Science ®Google Scholar
• Dang J, Tiwari SK, Lichinchi Get al.Zika virus depletes neural progenitors in human cerebral organoids through activation of the innate immune receptor TLR3. Cell Stem Cell 2016;19: 258–265.
   PubMed Web of Science ®Google Scholar
• Liang Q, Luo Z, Zeng Jet al.Zika virus NS4A and NS4B proteins deregulate Akt-mTOR signaling in human fetal neural stem cells to inhibit neurogenesis and induce autophagy. Cell Stem Cell 2016;19: 663–671.
   PubMed Web of Science ®Google Scholar
• Cao-Lormeau VM, Blake A, Mons Set al.Guillain-Barre syndrome outbreak associated with Zika virus infection in French Polynesia: a case-control study. Lancet 2016;387: 1531–1539.
   PubMed Web of Science ®Google Scholar
• Parra B, Lizarazo J, Jimenez-Arango JAet al.Guillain-Barre syndrome associated with Zika virus infection in Colombia. N Engl J Med 2016;375: 1513–1523.
   PubMed Web of Science ®Google Scholar
• D’Ortenzio E, Matheron S, Yazdanpanah Yet al.Evidence of sexual transmission of Zika virus. N Engl J Med 2016;374: 2195–2198.
   PubMed Web of Science ®Google Scholar
• Turmel JM, Abgueguen P, Hubert Bet al.Late sexual transmission of Zika virus related to persistence in the semen. Lancet 2016;387: 2501.
   PubMed Web of Science ®Google Scholar
• Brooks RB, Carlos MP, Myers RAet al.Likely sexual transmission of Zika virus from a man with no symptoms of infection - Maryland, 2016. MMWR Morb Mortal Wkly Rep 2016;65: 915–916.
   PubMed Web of Science ®Google Scholar
• Deckard DT, Chung WM, Brooks JTet al.Male-to-male sexual transmission of Zika virus—Texas, January 2016. MMWR Morb Mortal Wkly Rep 2016;65: 372–374.
   PubMed Web of Science ®Google Scholar
• Davidson A, Slavinski S, Komoto Ket al.Suspected female-to-male sexual transmission of Zika virus - New York City, 2016. MMWR Morb Mortal Wkly Rep 2016;65: 716–717.
   PubMed Web of Science ®Google Scholar
• Mansuy JM, Dutertre M, Mengelle Cet al.Zika virus: high infectious viral load in semen, a new sexually transmitted pathogen? Lancet Infect Dis 2016;16: 405.
   PubMed Web of Science ®Google Scholar
• Atkinson B, Hearn P, Afrough Bet al.Detection of Zika virus in semen. Emerg Infect Dis 2016;22: 940.
   PubMed Web of Science ®Google Scholar
• Visseaux B, Mortier E, Houhou-Fidouh Net al.Zika virus in the female genital tract. Lancet Infect Dis 2016;16: 1220.
   PubMed Web of Science ®Google Scholar
• Prisant N, Bujan L, Benichou Het al.Zika virus in the female genital tract. Lancet Infect Dis 2016;16: 1000–1001.
   PubMed Web of Science ®Google Scholar
• Nicastri E, Castilletti C, Balestra Pet al.Zika virus infection in the central nervous system and female genital tract. Emerg Infect Dis 2016;22: 2228–2230.
   PubMed Web of Science ®Google Scholar
• Yockey LJ, Varela L, Rakib Tet al.Vaginal exposure to Zika virus during pregnancy leads to fetal brain infection. Cell 2016;166: 1247–1256.
   PubMed Web of Science ®Google Scholar
• Tang WW, Young MP, Mamidi Aet al.A mouse model of Zika virus sexual transmission and vaginal viral replication. Cell Rep 2016;17: 3091–3098.
   PubMed Web of Science ®Google Scholar
• Govero J, Esakky P, Scheaffer SMet al.Zika virus infection damages the testes in mice. Nature 2016;540: 438–442.
   PubMed Web of Science ®Google Scholar
• Ma W, Li S, Ma Set al.Zika virus causes testis damage and leads to male infertility in mice. Cell 2016;167: 1511–1524.
   PubMed Web of Science ®Google Scholar
• Kutsuna S, Kato Y, Takasaki Tet al.Two cases of Zika fever imported from French Polynesia to Japan, December 2013 to January 2014. Euro Surveill 2014;19: 20683.
   PubMedGoogle Scholar
• Besnard M, Lastere S, Teissier Aet al.Evidence of perinatal transmission of Zika virus, French Polynesia, December 2013 and February 2014. Euro Surveill 2014;19: 20751.
   PubMedGoogle Scholar
• Gourinat AC, O’Connor O, Calvez Eet al.Detection of Zika virus in urine. Emerg Infect Dis 2015;21: 84–86.
   PubMed Web of Science ®Google Scholar
• Korhonen EM, Huhtamo E, Smura Tet al.Zika virus infection in a traveller returning from the Maldives, June 2015. Euro Surveill 2016;21: 30107.
   Google Scholar
• Zhang FC, Li XF, Deng YQet al.Excretion of infectious Zika virus in urine. Lancet Infect Dis 2016;16: 641–642.
   PubMed Web of Science ®Google Scholar
• Calvet G, Aguiar RS, Melo ASet al.Detection and sequencing of Zika virus from amniotic fluid of fetuses with microcephaly in Brazil: a case study. Lancet Infect Dis 2016;16: 653–660.
   PubMed Web of Science ®Google Scholar
• Oliveira Melo AS, Malinger G, Ximenes Ret al.Zika virus intrauterine infection causes fetal brain abnormality and microcephaly: tip of the iceberg? Ultrasound Obstet Gynecol 2016;47: 6–7.
   PubMed Web of Science ®Google Scholar
• Lanciotti RS, Kosoy OL, Laven JJet al.Genetic and serologic properties of Zika virus associated with an epidemic, Yap State, Micronesia, 2007. Emerg Infect Dis 2008;14: 1232–1239.
   PubMed Web of Science ®Google Scholar
• Bingham AM, Cone M, Mock Vet al.Comparison of test results for Zika virus RNA in urine, serum, and saliva specimens from persons with travel-associated Zika virus disease - Florida, 2016. MMWR Morb Mortal Wkly Rep 2016;65: 475–478.
   PubMed Web of Science ®Google Scholar
• Campos Rde M, Cirne-Santos C, Meira GLet al.Prolonged detection of Zika virus RNA in urine samples during the ongoing Zika virus epidemic in Brazil. J Clin Virol 2016;77: 69–70.
   PubMed Web of Science ®Google Scholar
• Roze B, Najioullah F, Ferge JLet al.Zika virus detection in urine from patients with Guillain-Barre syndrome on Martinique, January 2016. Euro Surveill 2016;21: 30154.
   PubMedGoogle Scholar
• Interim guidance for Zika virus testing of urine - United States, 2016. MMWR Morb Mortal Wkly Rep 2016;65: 474.
   PubMed Web of Science ®Google Scholar
• Wiwanitkit V.Urine-based molecular diagnosis of Zika virus. Int Urol Nephrol 2016;48: 2023.
   PubMed Web of Science ®Google Scholar
• Lamb LE, Bartolone SN, Kutluay SBet al.Advantage of urine based molecular diagnosis of Zika virus. Int Urol Nephrol 2016;48: 1961–1966.
   PubMed Web of Science ®Google Scholar
• Lamb LE, Bartolone SN, Kutluay SBet al.Reply to the letter: Urine based molecular diagnosis of Zika virus by Viroj Wiwanitkit. Int Urol Nephrol 2016;48: 2025.
   PubMed Web of Science ®Google Scholar
• Alcendor DJ.Zika virus infection of the human glomerular cells: implications for viral reservoirs and renal pathogenesis. J Infect Dis 2017.
   PubMed Web of Science ®Google Scholar
• Hamel R, Dejarnac O, Wichit Set al.Biology of zika virus infection in human skin cells. J Virol 2015;89: 8880–8896.
   PubMed Web of Science ®Google Scholar
• Deng YQ, Zhao H, Li XFet al.Isolation, identification and genomic characterization of the Asian lineage Zika virus imported to China. Sci China Life Sci 2016;59: 428–430.
   PubMed Web of Science ®Google Scholar
• Wu TD, Nacu S.Fast and SNP-tolerant detection of complex variants and splicing in short reads. Bioinformatics 2010;26: 873–881.
   PubMed Web of Science ®Google Scholar
• Anders S, Pyl PT, Huber W.HTSeq—a Python framework to work with high-throughput sequencing data. Bioinformatics 2015;31: 166–169.
   PubMed Web of Science ®Google Scholar
• Robinson MD, McCarthy DJ, Smyth GK.edgeR: a Bioconductor package for differential expression analysis of digital gene expression data. Bioinformatics 2010;26: 139–140.
   PubMed Web of Science ®Google Scholar
• Benjamini Y, Hochberg Y.Controlling the false discovery rate: a practical and powerful approach to multiple testing. J R Statist Soc B 1995;57: 289–300.
   Web of Science ®Google Scholar
• Eden E, Navon R, Steinfeld Iet al.GOrilla: a tool for discovery and visualization of enriched GO terms in ranked gene lists. BMC Bioinformatics 2009;10: 48.
   PubMed Web of Science ®Google Scholar
• Ryan MJ, Johnson G, Kirk Jet al.HK-2: an immortalized proximal tubule epithelial cell line from normal adult human kidney. Kidney Int 1994;45: 48–57.
   PubMed Web of Science ®Google Scholar
• Ming GL, Tang H, Song H.Advances in Zika virus research: stem cell models, challenges, and opportunities. Cell Stem Cell 2016;19: 690–702.
   PubMed Web of Science ®Google Scholar
• van den Pol AN, Mao G, Yang Yet al.Zika virus targeting in the developing brain. J Neurosci 2017;37: 2161–2175.
   PubMed Web of Science ®Google Scholar
• Simonin Y, Loustalot F, Desmetz Cet al.Zika virus strains potentially display different infectious profiles in human neural cells. EBioMedicine 2016;12: 161–169.
   PubMed Web of Science ®Google Scholar
• Tripathi S, Balasubramaniam VR, Brown JAet al.A novel Zika virus mouse model reveals strain specific differences in virus pathogenesis and host inflammatory immune responses. PLoS Pathog 2017;13: e1006258.
   PubMed Web of Science ®Google Scholar
• Grant A, Ponia SS, Tripathi Set al.Zika virus targets human STAT2 to inhibit type I interferon signaling. Cell Host Microbe 2016;19: 882–890.
   PubMed Web of Science ®Google Scholar