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Original Articles

Molecular analysis of pyrazinamide resistance in Mycobacterium tuberculosis in Vietnam highlights the high rate of pyrazinamide resistance-associated mutations in clinical isolates

PncA mutations and PZA resistance in M. tuberculosis in Vietnam

, , , , , , , , & show all
Pages 1-7 | Received 07 Dec 2016, Accepted 06 Aug 2017, Published online: 15 Jan 2019

References

  • Zumla A, Chakaya J, Centis Ret al.Tuberculosis treatment and management–an update on treatment regimens, trials, new drugs, and adjunct therapies. Lancet Resp Med 2015;3: 220–234.
  • Steele MA, Des Prez RM.The role of pyrazinamide in tuberculosis chemotherapy. Chest 1988;94: 845–850.
  • Heifets L, Lindholm-Levy P.Pyrazinamide sterilizing activity in vitro against semidormant Mycobacterium tuberculosis bacterial populations. Am Rev Resp Dis 1992;145: 1223–1225.
  • WHOGlobal tuberculosis report 2016 Available at http://www.who.int/tb/publications/global_report/en/.
  • WHO. WHO treatment guidelines for drug-resistant tuberculosis: 2016 update. Available at http://www.who.int/tb/areas-of-work/drug-resistant-tb/treatment/resources/.
  • Chang KC, Leung CC, Yew WWet al.Pyrazinamide may improve fluoroquinolone-based treatment of multidrug-resistant tuberculosis. Antimicrob Agents Chemother 2012;56: 5465–5475.
  • Zhang Y, Chiu Chang K, Leung CCet al.'Z(S)-MDR-TB' versus 'Z(R)-MDR-TB': improving treatment of MDR-TB by identifying pyrazinamide susceptibility. Emerg Microb Infect 2012;1: e5.
  • Zhang Y, Permar S, Sun Z.Conditions that may affect the results of susceptibility testing of Mycobacterium tuberculosis to pyrazinamide. J Med Microbiol 2002;51: 42–49.
  • Chedore P, Bertucci L, Wolfe Jet al.Potential for erroneous results indicating resistance when using the Bactec MGIT 960 system for testing susceptibility of Mycobacterium tuberculosis to pyrazinamide. J Clin Microbiol 2010;48: 300–301.
  • Hoffner S, Angeby K, Sturegard Eet al.Proficiency of drug susceptibility testing of Mycobacterium tuberculosis against pyrazinamide: the Swedish experience. Int J Tuberc Lung Dis 2013;17: 1486–1490.
  • Zignol M, Dean AS, Alikhanova Net al.Population-based resistance of Mycobacterium tuberculosis isolates to pyrazinamide and fluoroquinolones: results from a multicountry surveillance project. The Lancet infectious diseases 2016;16: 1185–1192.
  • Stoffels K, Mathys V, Fauville-Dufaux Met al.Systematic analysis of pyrazinamide-resistant spontaneous mutants and clinical isolates of Mycobacterium tuberculosis. Antimicrob Agents Chemother 2012;56: 5186–5193.
  • Petrella S, Gelus-Ziental N, Maudry Aet al.Crystal structure of the pyrazinamidase of Mycobacterium tuberculosis: insights into natural and acquired resistance to pyrazinamide. PLoS ONE 2011;6: e15785.
  • Zhang Y, Shi W, Zhang W, Mitchison D.Mechanisms of pyrazinamide action and resistance. Microbiol Spectr 2013;2: 1–12.
  • Zhang S, Chen J, Shi Wet al.Mutations in panD encoding aspartate decarboxylase are associated with pyrazinamide resistance in Mycobacterium tuberculosis. Emerg Microb Infect 2013;2: e34.
  • Shi W, Zhang X, Jiang Xet al.Pyrazinamide inhibits trans-translation in Mycobacterium tuberculosis. Science 2011;333: 1630–1632.
  • Miotto P, Cabibbe AM, Feuerriegel Set al.Mycobacterium tuberculosis pyrazinamide resistance determinants: a multicenter study. mBio 2014;5: e01819–01814.
  • Ramirez-Busby SM, Valafar F.Systematic review of mutations in pyrazinamidase associated with pyrazinamide resistance in Mycobacterium tuberculosis clinical isolates. Antimicrob Agents Chemother 2015;59: 5267–5277.
  • Scorpio A, Lindholm-Levy P, Heifets Let al.Characterization of pncA mutations in pyrazinamide-resistant Mycobacterium tuberculosis. Antimicrob Agents Chemother 1997;41: 540–543.
  • Hirano K, Takahashi M, Kazumi Yet al.Mutation in pncA is a major mechanism of pyrazinamide resistance in Mycobacterium tuberculosis. Tuber Lung Dis 1997;78: 117–122.
  • Bhuju S, Fonseca Lde S, Marsico AGet al.Mycobacterium tuberculosis isolates from Rio de Janeiro reveal unusually low correlation between pyrazinamide resistance and mutations in the pncA gene. Infect Genet Evolut 2013;19: 1–6.
  • Tan Y, Hu Z, Zhang Tet al.Role of pncA and rpsA gene sequencing in detection of pyrazinamide resistance in Mycobacterium tuberculosis isolates from southern China. J Clin Microbiol 2014;52: 291–297.
  • Li D, Hu Y, Werngren Jet al.Multicenter study of the emergence and genetic characteristics of pyrazinamide-resistant tuberculosis in China. Antimicrob Agents Chemother 2016;60: 5159–5166.
  • Gu Y, Yu X, Jiang Get al.Pyrazinamide resistance among multidrug-resistant tuberculosis clinical isolates in a national referral center of China and its correlations with pncA, rpsA, and panD gene mutations. Diagnos Microbiol Infect Dis 2016;84: 207–211.
  • Vietnam national tuberculosis control programme N. Guidline for Management of Multi-drug Resistance Tuberculosis 2009.
  • Nhung NV, Hoa NB, Sy DNet al.The fourth national anti-tuberculosis drug resistance survey in Viet Nam. Int J Tuberc Lung Dis 2015;19: 670–675.
  • WHO. Guidelines for surveillance of drug resistance in tuberculosis, 2nd ed.Geneva: WHO.2003.
  • Nguyen VA, Nguyen HQ, Vu TTet al.Reduced turn-around time for Mycobacterium tuberculosis drug susceptibility testing with a proportional agar microplate assay. Clin Microbiol Infect 2015;21: 1084–1092.
  • Kamerbeek J, Schouls L, Kolk Aet al.Simultaneous detection and strain differentiation of Mycobacterium tuberculosis for diagnosis and epidemiology. J Clin Microbiol 1997;35: 907–914.
  • Demay C, Liens B, Burguiere Tet al.SITVITWEB—a publicly available international multimarker database for studying Mycobacterium tuberculosis genetic diversity and molecular epidemiology. Infect Genet Evol 2012;12: 755–766.
  • Supply P, Allix C, Lesjean Set al.Proposal for standardization of optimized mycobacterial interspersed repetitive unit-variable-number tandem repeat typing of Mycobacterium tuberculosis. J Clin Microbiol 2006;44: 4498–4510.
  • Sandgren A, Strong M, Muthukrishnan Pet al.Tuberculosis drug resistance mutation database. PLoS Med 2009;6: e2.
  • Whitfield MG, Soeters HM, Warren RMet al.A global perspective on pyrazinamide resistance: systematic review and meta-analysis. PLoS One 2015;10: e0133869.
  • Aono A, Chikamatsu K, Yamada Het al.Association between pncA gene mutations, pyrazinamidase activity, and pyrazinamide susceptibility testing in Mycobacterium tuberculosis. Antimicrob Agents Chemother 2014;58: 4928–4930.
  • Martinez E, Holmes N, Jelfs Pet al.Genome sequencing reveals novel deletions associated with secondary resistance to pyrazinamide in MDR Mycobacterium tuberculosis. J Antimicrob Chemotherapy 2015;70: 2511–2514.
  • Hung NV, Ando H, Thuy TTet al.Clonal expansion of Mycobacterium tuberculosis isolates and coexisting drug resistance in patients newly diagnosed with pulmonary tuberculosis in Hanoi, Vietnam. BMC Res Notes 2013;6: 444.
  • Portugal I, Barreiro L, Moniz-Pereira Jet al.pncA mutations in pyrazinamide-resistant Mycobacterium tuberculosis isolates in Portugal. Antimicrob Agents Chemother 2004;48: 2736–2738.
  • Escalante P, Ramaswamy S, Sanabria Het al.Genotypic characterization of drug-resistant Mycobacterium tuberculosis isolates from Peru. Tuber Lung Dis 1998;79: 111–118.
  • Bamaga M, Wright DJ, Zhang H.Selection of in vitro mutants of pyrazinamide-resistant Mycobacterium tuberculosis. Int J Antimicrob Agents 2002;20: 275–281.
  • Jureen P, Werngren J, Toro JCet al.Pyrazinamide resistance and pncA gene mutations in Mycobacterium tuberculosis. Antimicrob Agents Chemother 2008;52: 1852–1854.
  • Rodrigues Vde F, Telles MA, Ribeiro MOet al.Characterization of pncA mutations in pyrazinamide-resistant Mycobacterium tuberculosis in Brazil. Antimicrob Agents Chemother 2005;49: 444–446.
  • Somoskovi A, Dormandy J, Parsons LMet al.Sequencing of the pncA gene in members of the Mycobacterium tuberculosis complex has important diagnostic applications: Identification of a species-specific pncA mutation in ‘Mycobacterium canettii’ and the reliable and rapid predictor of pyrazinamide resistance. J Clin Microbiol 2007;45: 595–599.
  • Chiu YC, Huang SF, Yu KWet al.Characteristics of pncA mutations in multidrug-resistant tuberculosis in Taiwan. BMC Infect Dis 2011;11: 240.
  • Xia Q, Zhao LL, Li Fet al.Phenotypic and genotypic characterization of pyrazinamide resistance among multidrug-resistant Mycobacterium tuberculosis isolates in Zhejiang, China. Antimicrob Agents Chemother 2015;59: 1690–1695.
  • Doustdar F, Khosravi AD, Farnia P.Mycobacterium tuberculosis genotypic diversity in pyrazinamide-resistant isolates of Iran. Microb Drug Resist 2009;15: 251–256.
  • Nguyen VA, Banuls AL, Tran THet al.Mycobacterium tuberculosis lineages and anti-tuberculosis drug resistance in reference hospitals across Viet Nam. BMC Microbiol 2016;16: 167.
  • den Hertog AL, Sengstake S, Anthony RM.Pyrazinamide resistance in Mycobacterium tuberculosis fails to bite? Pathogens Dis 2015;73: ftv037.
  • Muller B, Chihota VN, Pillay Met al.Programmatically selected multidrug-resistant strains drive the emergence of extensively drug-resistant tuberculosis in South Africa. PLoS One 2013;8: e70919.
  • Cohen KA, Abeel T, Manson McGuire Aet al.Evolution of extensively drug-resistant tuberculosis over four decades: whole genome sequencing and dating analysis of Mycobacterium tuberculosis isolates from KwaZulu-Natal. PLoS Med 2015;12: e1001880.