Advanced search
Publication Cover
Emerging Microbes & Infections Volume 7, 2018 - Issue 1
Submit an article Journal homepage
1,064
Views
11
CrossRef citations to date
0
Altmetric
Original Articles

Low population serum microneutralization antibody titer against the predominating influenza A(H3N2) N121K virus during the severe influenza summer peak of Hong Kong in 2017

Houshun ZhuDepartment of MicrobiologyLi Ka Shing Faculty of Medicine, The University of Hong KongHong Kong Special Administrative RegionChina
,
Andrew C. Y. LeeDepartment of MicrobiologyLi Ka Shing Faculty of Medicine, The University of Hong KongHong Kong Special Administrative RegionChina
,
Can LiDepartment of MicrobiologyLi Ka Shing Faculty of Medicine, The University of Hong KongHong Kong Special Administrative RegionChina
,
Winger W. N. MakDepartment of MicrobiologyLi Ka Shing Faculty of Medicine, The University of Hong KongHong Kong Special Administrative RegionChina
,
Yetta Y. ChenDepartment of MicrobiologyLi Ka Shing Faculty of Medicine, The University of Hong KongHong Kong Special Administrative RegionChina
,
Kwok-Hung ChanDepartment of MicrobiologyLi Ka Shing Faculty of Medicine, The University of Hong KongHong Kong Special Administrative RegionChina;Department of MicrobiologyQueen Mary HospitalHong Kong Special Administrative RegionChina;State Key Laboratory for Emerging Infectious Diseases, Li Ka Shing Faculty of MedicineThe University of Hong KongHong Kong Special Administrative RegionChina;Research Centre of Infection and Immunology, Li Ka Shing Faculty of MedicineThe University of Hong KongHong Kong Special Administrative RegionChina
,
Anna J. X. ZhangDepartment of MicrobiologyLi Ka Shing Faculty of Medicine, The University of Hong KongHong Kong Special Administrative RegionChina
,
Wai-Fong FungDepartment of MicrobiologyLi Ka Shing Faculty of Medicine, The University of Hong KongHong Kong Special Administrative RegionChina
,
Rui-Qi ZhangDepartment of MicrobiologyLi Ka Shing Faculty of Medicine, The University of Hong KongHong Kong Special Administrative RegionChina
,
Yim-Fong FungDepartment of MicrobiologyLi Ka Shing Faculty of Medicine, The University of Hong KongHong Kong Special Administrative RegionChina
,
Rosana W. S. PoonDepartment of MicrobiologyLi Ka Shing Faculty of Medicine, The University of Hong KongHong Kong Special Administrative RegionChina;Department of MicrobiologyQueen Mary HospitalHong Kong Special Administrative RegionChina
,
Joy-Yan LamResearch Centre of Infection and Immunology, Li Ka Shing Faculty of MedicineThe University of Hong KongHong Kong Special Administrative RegionChina
,
Sidney TamDivision of Clinical Biochemistry, Department of PathologyQueen Mary HospitalHong Kong Special Administrative RegionChina
,
Ivan F. N. HungState Key Laboratory for Emerging Infectious Diseases, Li Ka Shing Faculty of MedicineThe University of Hong KongHong Kong Special Administrative RegionChina;Research Centre of Infection and Immunology, Li Ka Shing Faculty of MedicineThe University of Hong KongHong Kong Special Administrative RegionChina;Department of Medicine, Li Ka Shing Faculty of MedicineThe University of Hong KongHong Kong Special Administrative RegionChina
,
Honglin ChenDepartment of MicrobiologyLi Ka Shing Faculty of Medicine, The University of Hong KongHong Kong Special Administrative RegionChina;State Key Laboratory for Emerging Infectious Diseases, Li Ka Shing Faculty of MedicineThe University of Hong KongHong Kong Special Administrative RegionChina;Research Centre of Infection and Immunology, Li Ka Shing Faculty of MedicineThe University of Hong KongHong Kong Special Administrative RegionChinaORCID Iconhttp://orcid.org/0000-0001-5108-8338
ORCID Icon,
Kwok-Yung YuenDepartment of MicrobiologyLi Ka Shing Faculty of Medicine, The University of Hong KongHong Kong Special Administrative RegionChina;Department of MicrobiologyQueen Mary HospitalHong Kong Special Administrative RegionChina;State Key Laboratory for Emerging Infectious Diseases, Li Ka Shing Faculty of MedicineThe University of Hong KongHong Kong Special Administrative RegionChina;Research Centre of Infection and Immunology, Li Ka Shing Faculty of MedicineThe University of Hong KongHong Kong Special Administrative RegionChinaCorrespondence[email protected]
&
Kelvin K. W. ToDepartment of MicrobiologyLi Ka Shing Faculty of Medicine, The University of Hong KongHong Kong Special Administrative RegionChina;Department of MicrobiologyQueen Mary HospitalHong Kong Special Administrative RegionChina;State Key Laboratory for Emerging Infectious Diseases, Li Ka Shing Faculty of MedicineThe University of Hong KongHong Kong Special Administrative RegionChina;Research Centre of Infection and Immunology, Li Ka Shing Faculty of MedicineThe University of Hong KongHong Kong Special Administrative RegionChinaCorrespondence[email protected]
 show all
Pages 1-9 | Received 04 Jan 2018, Accepted 30 Jan 2018, Published online: 06 Mar 2018

References

  • PaulesCSubbaraoKInfluenzaLancet2017390 697 70810.1016/S0140-6736(17)30129-0
  • PetrovaVNRussellCAThe evolution of seasonal influenza virusesNat. Rev. Microbiol.201816476010.1038/nrmicro.2017.118
  • PotterCWOxfordJSDeterminants of immunity to influenza infection in manBr. Med. Bull.197935697510.1093/oxfordjournals.bmb.a071545
  • MemoliMJEvaluation of antihemagglutinin and antineuraminidase antibodies as correlates of protection in an influenza A/H1N1 virus healthy human challenge modelmBio20167e004170041610.1128/mBio.00417-164959521
  • MontoASAntibody to influenza virus neuraminidase: an independent correlate of protectionJ. Infect. Dis.20152121191119910.1093/infdis/jiv195
  • World Health Organization.Recommended composition of influenza virus vaccines for use in the 2017-2018 northern hemisphere influenza seasonWkly. Epidemiol. Rec.201792117128
  • World Health Organization.Recommended composition of influenza virus vaccines for use in the 2018 southern hemisphere influenza seasonWkly. Epidemiol. Rec.201792625633
  • Centre for Health Protection.Local situation of influenza activity (as of Sept 27, 2017)Flu Express20171415
  • Tsou, T. P., Su, C. P., Huang, W. T., Yang, J. R., Liu, M. T. Influenza A(H3N2) virus variants and patient characteristics during a summer influenza epidemic in Taiwan, 2017. Eur. Surveill. 22, pii=17-00767 (2017).
  • ChambersBSParkhouseKRossTMAlbyKHensleySEIdentification of hemagglutinin residues responsible for H3N2 antigenic drift during the 2014-2015 influenza seasonCell Rep.2015121610.1016/j.celrep.2015.06.0054487778
  • DuganVGUpdate: influenza activity - United States, October 1-November 25, 2017MMWR Morb. Mortal. Wkly. Rep.2017661318132610.15585/mmwr.mm6648a25757637
  • TrebbienRChanges in genetically drifted H3N2 influenza A viruses and vaccine effectiveness in adults 65 years and older during the 2016/17 season in DenmarkJ. Clin. Virol.2017941710.1016/j.jcv.2017.06.007
  • Pebody, R., et al. End-of-season influenza vaccine effectiveness in adults and children, United Kingdom, 2016/17. Eur. Surveill.22, pii=17-00306 (2017).
  • FlanneryBInterim estimates of 2016-17 seasonal influenza vaccine effectiveness - United States, February 2017MMWR Morb. Mortal. Wkly. Rep.20176616717110.15585/mmwr.mm6606a35657861
  • WuNCA structural explanation for the low effectiveness of the seasonal influenza H3N2 vaccinePLoS Pathog.201713e100668210.1371/journal.ppat.10066825667890
  • ZostSJContemporary H3N2 influenza viruses have a glycosylation site that alters binding of antibodies elicited by egg-adapted vaccine strainsProc. Natl Acad. Sci. USA2017114125781258310.1073/pnas.17123771145703309
  • World Health Organization.Recommended composition of influenza virus vaccines for use in the 2016-2017 northern hemisphere influenza seasonWkly. Epidemiol. Rec.201691121132
  • SmithDJMapping the antigenic and genetic evolution of influenza virusScience200430537137610.1126/science.1097211
  • KoelBFSubstitutions near the receptor binding site determine major antigenic change during influenza virus evolutionScience201334297697910.1126/science.1244730
  • PopovaLImmunodominance of antigenic site B over site A of hemagglutinin of recent H3N2 influenza virusesPLoS ONE20127e4189510.1371/journal.pone.00418953405050
  • LongJEvolution of H3N2 influenza virus in a guinea pig modelPLoS ONE20116e2013010.1371/journal.pone.00201303142111
  • HuangZZYuLHuangPLiangLJGuoQCharged amino acid variability related to N-glyco -sylation and epitopes in A/H3N2 influenza: Hem -agglutinin and neuraminidasePLoS ONE201712e017823110.1371/journal.pone.01782315510802
  • WalkerDLHorsfallFLJr.Lack of identity in neutralizing and hemagglutination-inhibiting antibodies against influenza virusesJ. Exp. Med.195096586
  • GuoLHuman antibody responses to avian influenza A(H7N9) virus, 2013Emerg. Infect. Dis.20142019220010.3201/eid2002.1310943901473
  • TrueloveSA comparison of hemagglutination inhibition and neutralization assays for characterizing immunity to seasonal influenza AInfluenza Other Respir. Virus20161051852410.1111/irv.12408
  • VerschoorCPMicroneutralization assay titres correlate with protection against seasonal influenza H1N1 and H3N2 in childrenPLoS ONE201510e013153110.1371/journal.pone.01315314479562
  • LeeACSuboptimal humoral immune response against influenza A(H7N9) virus is related to its internal genesClin. Vaccin. Immunol.2015221235124310.1128/CVI.00443-15
  • ChenMISerological response in RT-PCR confirmed H1N1-2009 influenza a by hemagglutination inhibition and virus neutralization assays: an observational studyPLoS ONE20105e1247410.1371/journal.pone.00124742930007
  • NachbagauerRDefining the antibody cross-reactome directed against the influenza virus surface glycoproteinsNat. Immunol.20171846447310.1038/ni.36845360498
  • Center for Health Protection. Recommendations on Seasonal Influenza Vaccination for the 2017/18 Season. Available at http://www.chp.gov.hk/files/pdf/short_version_of_recommendations_on_seasonal_influenza_vaccination_for_the_2017_18.pdf. Accessed on 30 December 2017.
  • NohJYInterim estimates of the effectiveness of the influenza vaccine against A(H3N2) influenza in adults in South Korea, 2016-2017 seasonPLoS ONE201712e017801010.1371/journal.pone.01780105444786
  • RobertsonJSStructural changes in the haemagglutinin which accompany egg adaptation of an influenza A(H1N1) virusVirology1987160313710.1016/0042-6822(87)90040-7
  • KatzJMWebsterRGEfficacy of inactivated influenza A virus (H3N2) vaccines grown in mammalian cells or embryonated eggsJ. Infect. Dis.198916019119810.1093/infdis/160.2.191
  • SkowronskiDMLow 2012-13 influenza vaccine effectiveness associated with mutation in the egg-adapted H3N2 vaccine strain not antigenic drift in circulating virusesPLoS ONE20149e9215310.1371/journal.pone.00921533965421
  • HungIFTopical imiquimod before intradermal trivalent influenza vaccine for protection against heterologous non-vaccine and antigenically drifted viruses: a single-centre, double-blind, randomised, controlled phase 2b/3 trialLancet Infect. Dis.20161620921810.1016/S1473-3099(15)00354-0
  • ZhangAJHigh incidence of severe influenza among individuals over 50 years of ageClin. Vaccin. Immunol.2011181918192410.1128/CVI.05357-11
  • ToKKHigh titer and avidity of nonneutralizing antibodies against influenza vaccine antigen are associated with severe influenzaClin. Vaccin. Immunol.2012191012101810.1128/CVI.00081-12
  • LaurieKLInternational laboratory comparison of influenza microneutralization assays for A(H1N1)pdm09, A(H3N2), and A(H5N1) influenza viruses by CONSISEClin. Vaccin. Immunol.20152295796410.1128/CVI.00278-15
  • Centre for Health Protection. Statistics on Laboratory Surveillance. Influenza virus subtyping. Available at https://www.chp.gov.hk/en/statistics/data/10/641/643/2275.html. Accessed on 18 December 2017.
  • ShuYMcCauleyJGISAID: Global initiative on sharing all influenza data - from vision to realityEur. Surveill.2017223049410.2807/1560-7917.ES.2017.22.13.30494
  • ChenYHuman infections with the emerging avian influenza A H7N9 virus from wet market poultry: clinical analysis and characterisation of viral genomeLancet20133811916192510.1016/S0140-6736(13)60903-4
  • ToKKUnique reassortant of influenza A(H7N9) virus associated with severe disease emerging in Hong KongJ. Infect.201469606810.1016/j.jinf.2014.02.012

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.