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Emerging Microbes & Infections Volume 7, 2018 - Issue 1

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Original Articles

Emergence of a novel mobile colistin resistance gene, mcr-8, in NDM-producing Klebsiella pneumoniae

Xiaoming WangBeijing Advanced Innovation Center for Food Nutrition and Human Health, College of Veterinary MedicineChina Agricultural UniversityBeijingChina

Yao WangBeijing Advanced Innovation Center for Food Nutrition and Human Health, College of Veterinary MedicineChina Agricultural UniversityBeijingChina

Ying ZhouBeijing Advanced Innovation Center for Food Nutrition and Human Health, College of Veterinary MedicineChina Agricultural UniversityBeijingChina

Jiyun LiBeijing Key Laboratory of Detection Technology for Animal-Derived Food Safety and Beijing Laboratory for Food Quality and SafetyBeijingChina

Wenjuan YinBeijing Key Laboratory of Detection Technology for Animal-Derived Food Safety and Beijing Laboratory for Food Quality and SafetyBeijingChina

Shaolin WangBeijing Advanced Innovation Center for Food Nutrition and Human Health, College of Veterinary MedicineChina Agricultural UniversityBeijingChina

http://orcid.org/0000-0003-0866-4584

Suxia ZhangBeijing Key Laboratory of Detection Technology for Animal-Derived Food Safety and Beijing Laboratory for Food Quality and SafetyBeijingChina

Jianzhong ShenBeijing Advanced Innovation Center for Food Nutrition and Human Health, College of Veterinary MedicineChina Agricultural UniversityBeijingChina

http://orcid.org/0000-0002-8502-8445

Zhangqi ShenBeijing Advanced Innovation Center for Food Nutrition and Human Health, College of Veterinary MedicineChina Agricultural UniversityBeijingChinaCorrespondence[email protected]

Yang WangBeijing Key Laboratory of Detection Technology for Animal-Derived Food Safety and Beijing Laboratory for Food Quality and SafetyBeijingChinaCorrespondence[email protected]

http://orcid.org/0000-0002-5928-9377

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Pages 1-9 | Received 01 Mar 2018, Accepted 04 Jun 2018, Published online: 04 Jul 2018

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https://doi.org/10.1038/s41426-018-0124-z
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WangZQinRRHuangLSunLYRisk factors for carbapenem-resistant Klebsiella pneumoniae infection and mortality of Klebsiella pneumoniae infectionChin. Med. J.2018131 56 6210.4103/0366-6999.2212675754959
PubMed Web of Science ®Google Scholar
Su, C. et al. Treatment outcome of non-carbapenemase-producing carbapenem-resistant Klebsiella pneumoniae infections: a multicenter study in Taiwan. Eur. J. Clin. Microbiol. Infect. Dis. 10.1007/s10096-017-3156-8 (2017).
Google Scholar
FalagasMEKarageorgopoulosDENordmannPTherapeutic options for infections with Enterobacteriaceae producing carbapenem-hydrolyzing enzymesFuture Microbiol.2011665366610.2217/fmb.11.49
PubMed Web of Science ®Google Scholar
PoirelLJayolANordmannPPolymyxins: antibacterial activity, susceptibility testing, and resistance mechanisms encoded by plasmids or chromosomesClin. Microbiol. Rev.20173055759610.1128/CMR.00064-165355641
PubMed Web of Science ®Google Scholar
LiuYEmergence of plasmid-mediated colistin resistance mechanism MCR-1 in animals and human beings in China: a microbiological and molecular biological studyLancet Infect. Dis.20161616116810.1016/S1473-3099(15)00424-7
PubMed Web of Science ®Google Scholar
WangYPrevalence, risk factors, outcomes, and molecular epidemiology of mcr-1-positive Enterobacteriaceae in patients and healthy adults from China: an epidemiological and clinical studyLancet Infect. Dis.20171739039910.1016/S1473-3099(16)30527-8
PubMed Web of Science ®Google Scholar
YiLmcr-1-harboring salmonella enterica serovar typhimurium sequence type 34 in pigs, chinaEmerg. Infect. Dis.20172329129510.3201/eid2302.1615435324782
PubMed Web of Science ®Google Scholar
Luo, J. et al. Emergence of mcr-1 in Raoultella ornithinolytica and Escherichia coli from retail vegetables, China. Antimicrob. Agents Chemother. 61, pii:e01139–17 (2017).
Google Scholar
MendesAmcr-1 in carbapenemase-producing Klebsiella pneumoniae with hospitalized patients, Portugal, 2016-2017Emerg. Infect. Dis.20182476276610.3201/eid2404.1717875875258
PubMed Web of Science ®Google Scholar
PrincipeLMulticenter prospective study on the prevalence of colistin resistance in Escherichia coli: relevance of mcr-1-positive clinical isolates in Lombardy, Northern ItalyInfect. Drug. Resist.20181137738510.2147/IDR.S1604895849922
PubMed Web of Science ®Google Scholar
Yang, Y. et al. Novel plasmid-mediated colistin resistance gene mcr-7.1 in Klebsiella pneumoniae. J. Antimicrob. Chemother. 10.1093/jac/dky111 (2018).
Google Scholar
Xavier, B. B. et al. Identification of a novel plasmid-mediated colistin-resistance gene, mcr-2, in Escherichia coli, Belgium, 2016. Euro. Surveill. 21 (27):pii=30280 (2016).
Google Scholar
Garcia-GraellsCDetection of plasmid-mediated colistin resistance, mcr-1 and mcr-2 genes, in Salmonella spp. isolated from food at retail in Belgium from 2012 to 2015Foodborne Pathog. Dis.20181511411710.1089/fpd.2017.2329
PubMed Web of Science ®Google Scholar
YinWNovel plasmid-mediated colistin resistance gene mcr-3 in Escherichia coliMBio20178e005435487729
PubMed Web of Science ®Google Scholar
Carattoli, A. et al. Novel plasmid-mediated colistin resistance mcr-4 gene in Salmonella and Escherichia coli, Italy 2013, Spain and Belgium, 2015 to 2016. Euro. Surveill. 22, pii: 30589 (2017).
Google Scholar
BorowiakMIdentification of a novel transposon-associated phosphoethanolamine transferase gene, mcr-5, conferring colistin resistance in d-tartrate fermenting Salmonella enterica subsp. enterica serovar Paratyphi BJ. Antimicrob. Chemother.2017723317332410.1093/jac/dkx327
PubMed Web of Science ®Google Scholar
TeoJmcr-3 and mcr-4 variants in carbapenemase-producing clinical Enterobacteriaceae do not confer phenotypic polymyxin resistanceJ. Clin. Microbiol.201856e01562175824041
PubMed Web of Science ®Google Scholar
FukudaAHigh prevalence of mcr-1, mcr-3 and mcr-5 in Escherichia coli derived from diseased pigs in JapanInt. J. Antimicrob. Agents20185116316410.1016/j.ijantimicag.2017.11.010
PubMed Web of Science ®Google Scholar
BaileyDStructural and functional characterization of aerobactin synthetase iucA from a hypervirulent pathotype of Klebsiella pneumoniaeBiochemistry2016553559357010.1021/acs.biochem.6b004094928626
PubMed Web of Science ®Google Scholar
de CassiaAPresence of fimH, mrkD, andirp2 virulence genes in KPC-2-producing Klebsiella pneumoniae isolates in Recife-PE, BrazilCurr. Microbiol.20146982483110.1007/s00284-014-0662-0
PubMed Web of Science ®Google Scholar
HuangYmrkF is a component of type 3 fimbriae in Klebsiella pneumoniaeRes. Microbiol.2009160717910.1016/j.resmic.2008.10.009
PubMed Web of Science ®Google Scholar
HinchliffePInsights into the mechanistic basis of plasmid-mediated colistin resistance from crystal structures of the catalytic domain of MCR-1Sci. Rep.2017710.1038/srep393925216409
PubMed Web of Science ®Google Scholar
Stojanoski, V. et al. Structure of the catalytic domain of the colistin resistance enzyme MCR-1. BMC. Biology. 14, 81(2016).
Google Scholar
MaGZhuYYuZAhmadAZhangHHigh resolution crystal structure of the catalytic domain of MCR-1Sci. Rep.2016610.1038/srep395405175174
Web of Science ®Google Scholar
HuMCrystal structure of Escherichia coli originated MCR-1, a phosphoethanolamine transferase for colistin resistanceSci. Rep.2016610.1038/srep387935153839
Web of Science ®Google Scholar
Yao, Z., Feng, Y., Lin, J. & Zong, Z. Draft genome sequence of a colistin resistant Klebsiella pneumoniae clinical strain carrying the blaNDM-1 carbapenemase gene. Genome. Announc. 10.1128/genomeA.01654-16 (2017).
Google Scholar
AnandanAStructure of a lipid A phosphoethanolamine transferase suggests how conformational changes govern substrate bindingProc. Natl. Acad. Sci. USA20171142218222310.1073/pnas.1612927114
PubMed Web of Science ®Google Scholar
QuanJPrevalence of mcr-1 in Escherichia coli and Klebsiella pneumoniae recovered from bloodstream infections in China: a multicentre longitudinal studyLancet Infect. Dis.20171740041010.1016/S1473-3099(16)30528-X
PubMed Web of Science ®Google Scholar
SinghSEmergence of chromosome-borne colistin resistance gene mcr-1 in clinical isolates of Klebsiella pneumoniae from IndiaAntimicrob. Agents Chemother.201862e018851710.1128/AAC.00195-185786762
PubMed Web of Science ®Google Scholar
QuanJPrevalence of mcr-1 in Escherichia coli and Klebsiella pneumoniae recovered from bloodstream infections in China a multicentre longitudinal studyLancet Infect. Dis.2017440041010.1016/S1473-3099(16)30528-X
Web of Science ®Google Scholar
WangYComprehensive resistome analysis reveals the prevalence of NDM and MCR-1 in Chinese poultry productionNat. Microbiol.201721626010.1038/nmicrobiol.2016.260
PubMed Web of Science ®Google Scholar
BoutetEUniProtKB/Swiss-Prot, the manually annotated section of the UniProt knowledgebase: how to use the entry viewMethods Mol. Biol.20161374235410.1007/978-1-4939-3167-5_2
PubMedGoogle Scholar
GuptaSKARG-ANNOT, a new bioinformatic tool to discover antibiotic resistance genes in bacterial genomesAntimicrob. Agents Chemother.20145821222010.1128/AAC.01310-133910750
PubMed Web of Science ®Google Scholar
LeiLmcr-1 in Enterobacteriaceae from companion animals, Beijing, China, 2012-2016Emerg. Infect. Dis.20172371071110.3201/eid2304.1617325367392
PubMed Web of Science ®Google Scholar
KorogluMInvestigation of clonal relationships of K. pneumoniae isolates from neonatal intensive care units by PFGE and rep-PCRJ. Infect. Dev. Ctries.2015982983610.3855/jidc.6326
PubMed Web of Science ®Google Scholar

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