1,379
Views
19
CrossRef citations to date
0
Altmetric
Original Articles

Immunogenicity and protective efficacy against Treponema pallidum in New Zealand rabbits immunized with plasmid DNA encoding flagellin

, , , , , , , , , & show all
Pages 1-10 | Received 23 Apr 2018, Accepted 13 Sep 2018, Published online: 07 Nov 2018

References

  • PeelingRWHookEW3rdThe pathogenesis of syphilis: the Great Mimicker, revisitedJ. Pathol.2006208 224 23210.1002/path.1903
  • HookEW3rdPeelingRWSyphilis control--a continuing challengeNew Engl. J. Med.200435112212410.1056/NEJMp048126
  • HoELLukehartSASyphilis: using modern approaches to understand an old diseaseJ. Clin. Invest.20111214584459210.1172/JCI57173
  • LuHHigh frequency of the 23S rRNA A2058G mutation of Treponema pallidum in Shanghai is associated with a current strategy for the treatment of syphilisEmerg. Microbes & Infect.20154e1010.1038/emi.2015.10
  • NewmanLGlobal estimates of the prevalence and incidence of four curable sexually transmitted infections in 2012 based on systematic review and global reportingPLoS One201510e014330410.1371/journal.pone.0143304
  • LafondRELukehartSABiological basis for syphilisClin. Microbiol. Rev.200619294910.1128/CMR.19.1.29-49.2006
  • MetzgerMMichalskaEPodwinskaJSmogorWImmunogenic properties of the protein component of Treponema pallidumBr. J. Vener. Dis.1969452993041047997
  • MillerJNImmunity in experimental syphilis. VI. Successful vaccination of rabbits with Treponema pallidum, Nichols strain, attenuated by -irradiationJ. Immunol.197311012061215
  • LithgowKVCameronCEVaccine development for syphilisExpert. Rev. Vaccin.201716374410.1080/14760584.2016.1203262
  • LithgowKVA defined syphilis vaccine candidate inhibits dissemination of Treponema pallidum subspecies pallidumNat. Commun.2017810.1038/ncomms14273
  • ChampionCIMillerJNBorensteinLALovettMABlancoDRImmunization with Treponema pallidum endoflagella alters the course of experimental rabbit syphilisInfect. Immun.19905831583161313628
  • JiangCEvaluation of FlaB1, FlaB2, FlaB3, and Tp0463 of Treponema pallidum for serodiagnosis of syphilisDiagn. Microbiol. Infect. Dis.20168410511110.1016/j.diagmicrobio.2015.10.005
  • ZhaoFEnhanced immune response and protective efficacy of a Treponema pallidum Tp92 DNA vaccine vectored by chitosan nanoparticles and adjuvanted with IL-2Hum. Vaccin.201171083108910.4161/hv.7.10.16541
  • BernardeschiCTreponema pallidum induces systemic TH17 and TH1 cytokine responsesEur. J. Dermatol.: EJD201222797798
  • LukehartSAInvasion of the central nervous system by Treponema pallidum: implications for diagnosis and treatmentAnn. Intern. Med.198810985586210.7326/0003-4819-109-11-855
  • RadolfJDTreponema pallidum, the syphilis spirochete: making a living as a stealth pathogenNat. Rev. Microbiol.20161474475910.1038/nrmicro.2016.141
  • WhiteRGCan population differences explain the contrasting results of the Mwanza, Rakai, and Masaka HIV/sexually transmitted disease intervention trials?: A modeling studyJ. Acquir. Immune Defic. Syndr.2004371500151310.1097/01.qai.0000127062.94627.31
  • SongWSJeonYJNamgungBHongMYoonSIA conserved TLR5 binding and activation hot spot on flagellinSci. Rep.2017710.1038/srep40878
  • Eaves-PylesTFlagellin, a novel mediator of Salmonella-induced epithelial activation and systemic inflammation: I kappa B alpha degradation, induction of nitric oxide synthase, induction of proinflammatory mediators, and cardiovascular dysfunctionJ. Immunol.20011661248126010.4049/jimmunol.166.2.1248
  • McDermottPFCiacci-WoolwineFSnipesJAMizelSBHigh-affinity interaction between gram-negative flagellin and a cell surface polypeptide results in human monocyte activationInfect. Immun.2000685525552910.1128/IAI.68.10.5525-5529.2000
  • XuMTreponema pallidum flagellins elicit proinflammatory cytokines from human monocytes via TLR5 signaling pathwayImmunobiology201722270971810.1016/j.imbio.2017.01.002
  • JiangCTreponema pallidum flagellins stimulate MMP-9 and MMP-13 expression via TLR5 and MAPK/NF-kappaB signaling pathways in human epidermal keratinocytesExp. Cell Res.2017361465510.1016/j.yexcr.2017.09.040
  • NorrisSJCharonNWCookRGFuentesMDLimbergerRJAntigenic relatedness and N-terminal sequence homology define two classes of periplasmic flagellar proteins of Treponema pallidum subsp. pallidum and Treponema phagedenisJ. Bacteriol.19881704072408210.1128/jb.170.9.4072-4082.1988
  • WonGLeeJHMultifaceted immune responses and protective efficacy elicited by a recombinant autolyzed Salmonella expressing FliC flagellar antigen of F18(+)Escherichia coliVaccine2016346335634210.1016/j.vaccine.2016.10.066
  • GurunathanSKlinmanDMSederRADNA vaccines: immunology, application, and optimization*Annu. Rev. Immunol.20001892797410.1146/annurev.immunol.18.1.927
  • MontgomeryDLHeterologous and homologous protection against influenza A by DNA vaccination: optimization of DNA vectorsDNA Cell Biol.19931277778310.1089/dna.1993.12.777
  • WenYMAntigen-antibody immunogenic complex: promising novel vaccines for microbial persistent infectionsExpert. Opin. Biol. Ther.2009928529110.1517/14712590802715749
  • LiuSWangSLuSDNA immunization as a technology platform for monoclonal antibody inductionEmerg. Microbes & Infect.20165e3310.1038/emi.2016.27
  • ArrollTWCenturion-LaraALukehartSAVan VoorhisWCT-Cell responses to Treponema pallidum subsp. pallidum antigens during the course of experimental syphilis infectionInfect. Immun.1999674757476396806
  • PodwinskaJLusiakMZabaRBowszycJThe pattern and level of cytokines secreted by Th1 and Th2 lymphocytes of syphilitic patients correlate to the progression of the diseaseFems. Immunol. Med. Microbiol.20002811410.1111/j.1574-695X.2000.tb01451.x
  • LeaderBTGodornesCVanVoorhisWCLukehartSACD4+ lymphocytes and gamma interferon predominate in local immune responses in early experimental syphilisInfect. Immun.2007753021302610.1128/IAI.01973-06
  • StaryGHost defense mechanisms in secondary syphilitic lesions: a role for IFN-gamma-/IL-17-producing CD8+ T cells?Am. J. Pathol.20101772421243210.2353/ajpath.2010.100277
  • MooreMWPhagocytosis of Borrelia burgdorferi and Treponema pallidum potentiates innate immune activation and induces gamma interferon productionInfect. Immun.2007752046206210.1128/IAI.01666-06
  • MeansTKHayashiFSmithKDAderemALusterADThe Toll-like receptor 5 stimulus bacterial flagellin induces maturation and chemokine production in human dendritic cellsJ. Immunol.20031705165517510.4049/jimmunol.170.10.5165
  • ZhaoYShaoFThe NAIP-NLRC4 inflammasome in innate immune detection of bacterial flagellin and type III secretion apparatusImmunol. Rev.20152658510210.1111/imr.12293
  • HayashiFThe innate immune response to bacterial flagellin is mediated by Toll-like receptor 5Nature20014101099110310.1038/35074106
  • ChowYHDevelopment of Th1 and Th2 populations and the nature of immune responses to hepatitis B virus DNA vaccines can be modulated by codelivery of various cytokine genesJ. Immunol.199816013201329
  • HasanUAAbaiAMHarperDRWrenBWMorrowWJNucleic acid immunization: concepts and techniques associated with third generation vaccinesJ. Immunol. Methods199922912210.1016/S0022-1759(99)00104-0
  • KriegAMCpG motifs in bacterial DNA and their immune effectsAnnu. Rev. Immunol.20022070976010.1146/annurev.immunol.20.100301.064842
  • WenYMMuLShiYImmunoregulatory functions of immune complexes in vaccine and therapyEMBO Mol. Med.201681120113310.15252/emmm.201606593
  • CruzARImmune evasion and recognition of the syphilis spirochete in blood and skin of secondary syphilis patients: two immunologically distinct compartmentsPLoS Negl. Trop. Dis.20126e171710.1371/journal.pntd.0001717
  • Baker-ZanderSALukehartSAMacrophage-mediated killing of opsonized Treponema pallidumJ. Infect. Dis.1992165697410.1093/infdis/165.1.69
  • Baker-ZanderSAShafferJMLukehartSACharacterization of the serum requirement for macrophage-mediated killing of Treponema pallidum ssp. pallidum: relationship to the development of opsonizing antibodiesFems. Immunol. Med. Microbiol.1993627327910.1111/j.1574-695X.1993.tb00339.x
  • ShafferJMBaker-ZanderSALukehartSAOpsonization of Treponema pallidum is mediated by immunoglobulin G antibodies induced only by pathogenic treponemesInfect. Immun.199361781784302795
  • HawleyKLIFNγ enhances CD64-potentiated phagocytosis of Treponema pallidum opsonized with human syphilitic serum by human macrophagesFront. Immunol.20178122710.3389/fimmu.2017.01227
  • van VoorhisWCBarrettLKNasioJMPlummerFALukehartSALesions of primary and secondary syphilis contain activated cytolytic T cellsInfect. Immun.19966410481050173879
  • Andersen-NissenEEvasion of Toll-like receptor 5 by flagellated bacteriaProc. Natl Acad. Sci. USA20051029247925210.1073/pnas.0502040102
  • RamosHCRumboMSirardJCBacterial flagellins: mediators of pathogenicity and host immune responses in mucosaTrends Microbiol.20041250951710.1016/j.tim.2004.09.002
  • ParkerMLThe structure of Treponema pallidum Tp0751 (pallilysin) reveals a non-canonical lipocalin fold that mediates adhesion to extracellular matrix components and interactions with host cellsPLoS Pathog.201612e100591910.1371/journal.ppat.1005919
  • LawnJEStillbirths: rates, risk factors, and acceleration towards 2030Lancet201638758760310.1016/S0140-6736(15)00837-5
  • LukehartSABaker-ZanderSALloydRMSellSCharacterization of lymphocyte responsiveness in early experimental syphilis. II. Nature of cellular infiltration and Treponema pallidum distribution in testicular lesionsJ. Immunol.1980124461467
  • Lukehart, S. A. & Marra, C. M. Isolation and laboratory maintenance of Treponema pallidum. Curr. Protoc. Microbiol.Chapter 12, Unit 12A.1 (2007).
  • Centurion-LaraATreponema pallidum major sheath protein homologue Tpr K is a target of opsonic antibody and the protective immune responseJ. Exp. Med.199918964765610.1084/jem.189.4.647