Rats Receiving the Slimming Agent Oleoyl-Estrone in Liposomes (Merlin-2) Decrease Food Intake but Maintain Thermogenesis

References

• ARDEVOL A, ADAN C, FERNANDEZ-LOPEZ JA, PÉREZ J, CORTS JL, BINAGUI D, REMESAR X, ALEMANY, M (1995): Tread-mill chamber for studies of respiratory gas exchange in the rat during exercise. Arch Physiol Biochem 103: 175–186
   Google Scholar
• BALADA F, SANCHIS D, GRASA MM, VIRGILI J, ESTRUCH J, FERNANDEZ-LOPEZ, JA, REMESAR X, ALEMANY M (1997a): Effect of the slimming agent oleoyl-estrone in liposomes on the body weight of Zucker obese rats. Int J Obesity 21: 789–795.
   Google Scholar
• BALADA F, SANCHIS D, GRASA MM, VIRGILI J, ESTRUCH J, FERNANDEZ-LOPEZ, JA, REMESAR X, ALEMANY M (1997b): Effect of the slimming agent oleoyl-estrone in liposomes on the body weight of rats fed a cafeteria diet. Arch Physiol Biochim 105:487–495.
   Google Scholar
• BORG W, SHACKLETON CHL, PAHUJA SL, HOCHBERG RB (1995): Long-lived testosterone esters in the rat. Proc Natl Acad Sci USA 92: 1545–1549.
   PubMed Web of Science ®Google Scholar
• BRADFORD MM (1976): A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 72: 248–254.
   PubMed Web of Science ®Google Scholar
• BRIND J, STRAIN G, MILLER L, ZUMOFF B, VOGELMAN J, ORENTREICH, N (1990): Obese men have elevated plasma-levels of estrone sulfate. Int J Obesity 14: 483–486.
   PubMed Web of Science ®Google Scholar
• CLEARY MP (1991): The anti-obesity effect of dehy-droepiandrosterone in rats. Proc Soc Exp Biol Med 196: 8–16.
   PubMed Web of Science ®Google Scholar
• FAUST WI (1981): Signals from adipose tissue. In: The body weight regulatory system: normal and disturbed mecha-nisms. CIOFFI LA, JAMES WPT, VAN ITALLIE TB, eds., Raven Press, New York, pp. 39-43.
   Google Scholar
• FEHER T, BODROGI, L (1982): A comparative study of steroid concentrations in human adipose-tissue and the periph-eral-circulation. Clin Chim Acta 126: 135–141.
   PubMed Web of Science ®Google Scholar
• FOLCH J, LEES M, SLOANE-STANLEY GH (1957): A simple method for the isolation and purification of total lipids from animal tissues. J Biol Chem 232: 497–509.
   Google Scholar
• FREDMAN MR, HORWITZ BA, STERN JS (1986): Effect of adrenalectomy and glucocorticoid replacement on devel-opment of obesity. Am J Physiol 250: R595—R607.
   PubMed Web of Science ®Google Scholar
• FRICKER J, ROZEN R, MELCHIOR JC, APFELBAUM M (1991): Energy-metabolism adaptation in obese adults on a very-low-calorie diet. Am J Clin Nutr 53: 826–830.
   Google Scholar
• GRAY JI\4, SCHROCK S, BISHOP M (1993): Estrogens and antie-strogens — actions and interactions with fluphenazine on food-intake and body-weight in rats. Am J Physiol 264: R1214—R1218.
   Google Scholar
• HERRON D, CANNON B, REHNMARK S, NELSON BD, NECHAD M, NEDERGAARD J (1989): Effects of cholera-toxin on gene-expression in brown preadipocytes differentiating in culture. Am J Physiol 257: C920—C925.
   PubMed Web of Science ®Google Scholar
• KILLINGER DW, STRUTT BJ, RONCARI DA, KHALIL MW (1995): Estrone formation from dehydroepiandrosterone in cultured human breast adipose stromal cells. J Steroid Biochem Mol Biol 52: 195–201.
   PubMed Web of Science ®Google Scholar
• LAUDENSLAGER ML, WILKINSON CW, CARLISLE HJ, HAMMEL HT (1980): Energy balance in ovariectomized rats with
   Google Scholar
• and without estrogen replacement. Am J Physiol 238: R400—R405.
   Google Scholar
• LEIBEL RL, ROSENBAUM M, HIRSCH J (1995): Changes in energy expenditure resulting from altered body weight. N Engl J Med 332: 621–628.
   PubMed Web of Science ®Google Scholar
• LOBO MJ, REMESAR X, ALEMANY M (1993): Effect of chronic intravenous injection of steroid hormones on body weight and composition of female rats. Biochem Mol Biol Int 29: 349–358.
   PubMedGoogle Scholar
• MELLON-NUSSBAUM SH, PONTICORVO L, SCHATZ F, HOCHBERG RS (1982): Estradiol fatty acid esters. J Biol Chem 257: 5678–5684.
   PubMed Web of Science ®Google Scholar
• RAFECAS I, ESTEVE M, FERNANDEZ-LOPEZ JA, REMESAR X, ALEMANY M (1994): Whole-rat protein-content estimation — Applicability of the N-X-6.25 Factor. Br J Nutr 72: 199–209.
   Google Scholar
• RAMIREZ 1(1980): Relation between estrogen-induced hyper-lipemia and food intake and body weight in rats. Physiol Behav 25: 511–518.
   Google Scholar
• REMESAR X, FERNANDEZ-LOPEZ JA, ALEMANY M (1993): Steroid hormones and the control of body weight. Med Res Rev 13: 623–631.
   PubMed Web of Science ®Google Scholar
• REMESAR X, FERNANDEZ-LOPEZ JA, ALEMANY M (1997): Is leptin an insulin counter-regulatory hormone? FEBS Lett 402: 9–12.
   Google Scholar
• SANCHIS D, BALADA F, GRASA MM, VIRGILI J, PEINADO J, MONSERRAT C, FERNANDEZ-LOPEZ JA, REMESAR X, ALE-
   Google Scholar
• MANY M (1996): Oleoyl-estrone induces the loss of body fat in rats. Int J Obesity 20: 588–594.
   Web of Science ®Google Scholar
• SANCHIS D, ADAN C, ARDEVOL A, GRASA MM, CABOT C, BALADA F, VILA R, ESTRUCH J, PUERTA M, FERNANDEZ-LOPEZ JA, REMESAR X, ALEMANY M (1997): Short term-treatment with oleoyl-estrone in liposomes (Merlin-2): strongly reduces the expression of the ob gene in young rats. Biochem J 326: 357–360.
   Google Scholar
• SCALFI L, ALFIERI R, BORRELLI R, CONTALDO F, DECATERINA M, MANCINI M, SPAGNUOLO G (1987): Protein balance during very-low-calorie diets for the treatment of severe obesity. Ann Nutr Metab 31: 154–159.
   PubMed Web of Science ®Google Scholar
• SCHNEIDER G, KIRSCHNER MA, BERKOWITZ R, ERTEL NH (1979): Increased estrogen production in obese men. J Clin Endocrinol Metab 48: 633–638.
   PubMed Web of Science ®Google Scholar
• VAGUE J, JUBELIN J, MEIGNEN JM, NEGRIN JF, THOMAS M, TRAMONI M (1984): Androgens, estrogens and cortisol in adipose tissue physiopathology. 1. Sem Hop 60: 1389–1393; 1465–1476.
   Google Scholar
• ZHANG Y, PROENCA R, MAFFEI M, BARONE M, LEOPOLD L, FRIEDMAN JM (1994): Positional cloning of the mouse obese gene and its human homologue. Nature 372: 425–431.
   PubMed Web of Science ®Google Scholar