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Research Article

Trophic and Tropic Factors in the Development of the Central Nervous System

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Pages 161-202 | Published online: 03 Oct 2008

References

  • Adli DSH, Rosenthal BM, Yuen GL, Ho RH, Cruce WLR (1988): Immunohistochemical localization of substance P, somatostatin, enkephalin, and serotonin in the spinal cord of the northern leopard frog, rana pipiens. J Comp Neurol 275: 106–116.
  • Aizenman Y, de Vellis J (1987): Brain neurons develop in a serum and glial free environment: effects of transferrin, insulin, insulin-like growth factor-I and thyroid hormone on neuronal survival, growth and differentiation. Brain Res 406: 32–42.
  • Alderson RF, Alterman AL, Barde YA, Lindsay RM. Brain-derived neurotrophic factor increases survival and differ-entiated functions of rat septal cholinergic neurons in culture. Neuron 5: 297–306, 1990.
  • Aloe L, Levi-Montalcini R. Mast cell increase in tissues of neonatal rats injected with nerve growth factor. Brain Res 133: 358–366, 1977.
  • Anderson IK, Edwall D, Norstedt G, Rozell B, Skottner A, Hans son HA. Differing expression of insulin-like growth factor I in the developing and in the adult rat cerebellum. Acta Physiol Scand 132: 167–173, 1988.
  • Andreasson KI, Barnes CA, Worley PF. P-A activin is regu-lated by synaptic activity and is expressed in the develop-ing rat brain. Soc Neurosci Abstr 20: 691.11, 1994.
  • Arai H, Emson PC. Regional distribution of neuropeptide K and other tachykinins (neurokinin A, neurokinin B and substance P) in rat central nervous system. Brain Res 399: 240–249, 1986.
  • Arakawa Y, Sendtner M, Thoenen H. Survival effect of ciliary neurotrophic factor on chick embryonic motoneurons in culture: comparison with other neurotrophic factors and cytokines. J Neurosci 10(11): 3507–3515, 1990.
  • Ardelt AA, Flaris NA, Roth KA. Neurotrophin-4 selectively promotes survival of striatal neurons in organotypic slice culture. Brain Res 647: 340–344, 1994.
  • Auburger G, Heumann R, Hellweg R, Korsching S, Thoenen H. Developmental changes of nerve growth factor and its mRNA in the rat hippocampus: comparison with choline acetyltransferase. Dev Biol 120: 322–328, 1987.
  • Averbuch-Heller L, Pruginin M, Kahane N, Tsoulfas P, Parada L, Rosenthal A, Kalcheim C. Neurotrophin 3 stimulates the differentiation of motoneurons from avian tube progenitor cells. Proc Natl Acad Sci USA 91 (8): 3247–3251, 1994.
  • Bach MA, Shen-Orr Z, Lowe WL, Roberts CT, LeRoith D. Insulin-like growth factor I mRNA levels are develop-mentally regulated in specific regions of the rat brain. Brain Res Mol Brain Res 10: 43–48, 1991.
  • Baird A. Fibroblast growth factors: activities and significance of non-neurotrophin neurotropic growth factors. Current opinion in neurobiology 4: 78–86, 1994.
  • Barde YA. What, if anything, is a neurotrophic factor ? Trends in neuroscience 11 (8): 343–346, 1988.
  • Barde YA, Davies AM, Johnson JE, Lindsay RM, Thoenen H. Brain Derived Neurotrophic Factor. Prog Brain Res 71: 185–189, 1987.
  • Barde YA, Edgar D, Thoenen H. Purification of a new neu-rotrophic factor from mammalian brain. EMBO J 1: 549–553, 1982.
  • Béchade C, Devignot V, Triller A. BDNF promotes survival of rat spinal dorsal horn neurons in vitro. Soc Neurosci Abstr 20: 285.19, 1994.
  • Beck KD, Knusel B, Hefti F. The nature of the trophic action of brain-derived neurotrophic factor, des(1–3)-insulin-like growth factor 1, and basic fibroblast grwoth factor on mes-encephalic dopaminergic neurons developing in culture. Neuroscience 52 (4): 855–866, 1993.
  • Beck KD, Powell-Braxton L, Widmer HR, Valverde J, Hefti F. IGF-1 gene disruption results in reduced brain size, CNS hypomyelisation, and loss of hippocampal granule and striatal parvalbumin-containing neurons. Neuron 14(4): 717–730, 1995.
  • Behar 0, Golden JA, Mashimo H, Schoen FJ, Fishman MC. Semaphorin III is needed for normal patterning and growth of nerves, bones and heart. Nature 383: 525–528, 1996.
  • Behar TN, Schaffner AE, Colton CA, Somogyi R, Olah Z, Lehel C, Barker JL. GABA-induced chemokinesis and NGF-induced chemotaxis of embryonic spinal cord neu-rons. J Neurosci 14 (1): 29–38, 1994.
  • Berezovskaya 0, Maysinger D, Fedoroff S. The hematopoi-etic cytokine, colony-stimulating factor 1, is also a growth factor in the CNS: congenital absence of CSF-1 in mice results in abnormal microglial response and increased neuron vulnerability to injury. Int J Dev Neurosci 13: 285–299, 1995.
  • Berkemeier LR, Winslow JW, Kaplan DR, Nikolics K, Goed-del DR, Rosenthal A. Neurotrophin-5: a novel neu-rotrophic factor that activates trk and trkB. Neuron 7: 857–866, 1991.
  • Bernhardt RR, Nguyen N, Kuwada JY. Growth cone guid-ance by floor plate cells in the spinal cord of zebrafish embryos. Neuron 8: 869–882, 1992.
  • Birecree E, King LE, Nanney LB. EGF and its receptor in the developing human nervous system. Brain Res Dev Brain Res 60 (2): 145–154, 1991.
  • Blackman CF, Benane SG, House DE. Evidence for direct effect of magnetic fields on neurite outgrowth. FASEB J 7: 801–806, 1993.
  • Bohannon NJ, Corp ES, Wilcox BJ, Figlewicz DP, Dorsa DM, Baskin DG. Localization of binding sites for insulin-like growth factor I in the rat brain by quantitative auto-radiography. Brain Res 444: 205–213, 1988.
  • Bondy CA, Lee WH. Patterns of insulin-like growth factor and IGF receptor gene expression in the brain. Functional implications. Ann NY Acad Sci 692: 33–43, 1993.
  • Borson S, Miller M, Leverenz J, Unis A, Bothwell M. BDNF mRNA in the human locus coeruleus. Soc Neurosci Abstr 20: 537.6, 1994.
  • Bothwell M. Keeping track of neurotrophin receptors. Cell 65: 915–916, 1991.
  • Boutros T, Croze E, Young VW. Interferon-beta is a potent promoter of nerve growth factor production by astrocytes. J Neurochem 69(3): 939–946, 1997.
  • Bovolenta P, Dodd J. Guidance of commisural growth cones at the floor plate in embryonic rat spinal cord. Develop-ment 109: 435–447, 1990.
  • Bozycko-Coyne D, Glicksman MA, Pranther JE, McKenna B, Connors T, Friedman C, Dasgupta M, Neff NT. IGF-I supports the survival and /or differentiation of multiple types of central nervous system neurons. Ann NY Acad Sci 692: 311–313,1993.
  • Bradshaw RA, Hogue-Angeletti RA, Frazier WA. Nerve growth factor and insulin: evidence of similarities in struc-ture, function and mechanism of action. Rec Frog Horm Res 38: 575–596,1974.
  • Breder CD, Tsujimoto M, Terano Y, Scott DW, Saper CB. Distribution and characterization of tumor necrosis factor a like immunoreactivity in the murine central nervous system. J Comp Neurol 337(4): 543–567,1993.
  • Brenneman DE, Schultzberg M, Bartfai T, Gozes I. Cytokine regulation of neuronal survival. J Neurochem 58: 45/1 '160,1992.
  • Buravsky VA, Gronskaya RI, Shpak GA, Lustchitskaya NI, Kalunov VN. Epidermal growth factor influences the neu-rotrophic/differenting action of nerve growth factor. Int J Dev neurosci 13 (5): 483–489,1995.
  • Carlson CD, Bai Y, Jonakait GM, Hart RP. Interleukin-1 beta increases leukemia inhibitory factor mRNA levels through transient stimulation of transcription rate. Glia 18: 141–151,1996.
  • Carman-Krzan M, Vige X, Wise B. Regulation by inter-leukin-1 of nerve growth factor secretion and nerve growth factor mRNA expression in rat primary astroglial cultures. J Neurochem 56: 636–643,1991.
  • Cam NG, Rubin K, Gullberg D, Ebendal T. Neuritogenesis on collagen substrates. Involvement of integrin-like matrix receptors in retinal fibre outgrowth on collagen. Int J Dev Neurosci 10: 393–405,1992.
  • Casper D, Mytilineou C, Blum M. EGF enhances the sur-vival of dopamine neurons in rat embryonic mesen-cephalon primary cell culture. J Neurosci Res 30 (2): 372–381,1991.
  • Casper D, Roboz GJ, Blum M. Epidermal growth factor and basic fibroblast growth factor have independent actions on mesencephalic dopamine neurons in culture. J Neurochem 62 (6): 2166–2177,1994.
  • Causing C, Gloster A, Aloyz R, Bamji SX, Chang E, Fawcett J, Kuchel G, Miller FD. Synaptic innervation density is regulated by neuron-derived BDNF. Neuron 18: 257–267, 1997.
  • Chaldakov GN, Ghenev PI, Andonov M, Valchanov K, Tonchev A, Pancheva R. Neural-immune-effector (NIE) cross-talk in vascular trophobiology: proposal for new and not yet exploited purinergic regulatory mechanisms. Bio-medical reviews 3: 81–86,1994.
  • Chan SO, Guillery RW. Changes in fiber order in the optic nerve and tract of rat embryos. J Comp Neurol 344: 20–32,1994.
  • Chang Y, Albright S, Lee F. Cytokines in the central nervous system: expression of macrophage colony stimulatig fac-tor and its receptor during development. J Neuroimmunol 52: 9–17,1994.
  • Chao MV. Neurotrophin receptors: a window into neuronal differentiation. Neuron 9: 583–593,1992.
  • Chao MV, Hempstead BL. p75 and Trk: a two-receptor sys-tem. Trends in Neurosciences 18 (7): 321–326,1995.Chen H, Chedotal A, He Z, Goodman CS, Tessier-LavigneM. Neuropilin-2, a novel member of the neuropilin fam- ily, is a high affinity receptor for the semaphorins sema E and sema IV but not sema III. Neuron 19: 547–559,1997.
  • Choi-Lundberg DL, Bohn MC. Ontogeny and distribution of glial cell line-derived neurotrophic factor (GDNF) mRNA in rat. Brain Res Dev Brain Res 85: 80–88,1995.
  • Cockayne DA, Bodine DM, Cline A, Nienhuis AW, Dunbar CE. Transgenic mice expressing antisense interleukin-3 RNA develop a B-cell lymphoproliferative syndrome or neurologic dysfunction. Blood 84 (8): 2699–2710,1994.
  • Colamarino SA, Tessier-Lavigne M. The axonal chemoat-tractant netrin-1 is also a chemorepellent for trochlear motor axons. Cell 81: 621–629,1995.
  • Collarini EJ, Pringle N, Mudhar H, Stevens G, Kuhn R, Monuki ES, Lemke G, Richardson WD. Growth factors and transcription factors in oligodendrocyte development. J Cell Sci Suppl 15: 117–123,1991.
  • Collazo D, Takahashi H, McKay RDG. Cellular targets and trophic functions of neurotrophin-3 in the developing rat hippocampus. Neuron 9: 643–656,1992.
  • Collins F, Lee MR. The spatial control of ganglionic neurite growth by the substrate-associated material from condi-tioned medium: an experimantal model of haptotaxis. J Neurosci 4: 2823–2829,1984.
  • Conover JC, Erickson JT, Katz DM, Bianchi LM, Poueymirou WT, McClain J, Pan L, Helgren M, Ip NY, Boland P. Neuronal deficits, not involving motoneurons, in mice lacking BDNF and/or NT4. Nature 375: 235–238, 1995.
  • Crain SM, Wiegand RG. Catecholamine levels of mouse sympathetic ganglia following hypertrophy produced by salivary nerve-growth factor. Proc Soc exp Biol Med 107: 663–665,1961.
  • Crowley C, Spencer SD, Nishimura MC, Chen KS, Pitts-Meek S, Armanini MP, Ling Lh, MacMahon SB, Shelton DL, Levinson AD. Mice lacking nerve growth factor dis-play perinatal loss of sensory and sympathetic neurons yet develop basal forebrain cholinergic neurons. Cell 76: 1001–1011,1994.
  • Crutcher KA. The role of growth factors in neuronal develop-ment and plasticity. Critical reviews in clinical neurobiol-ogy 2 (3): 297–333,1986.
  • Culotti JG. Axon guidance mechanisms in Caenorhabdis ele-gans. Curr Opin Genet Dev 4: 587–595,1994.
  • D'Alessandro JS, Yetz-Aldape J, Wang EA. Bone Morpho-genetic Proteins induce differentiation in astrocyte lineage cells. Growth Factors 11 (1): 53–69,1994.
  • Damon DH, Lobb RR, D'Amore PA, Wagner JA. Heparin potentiates the action of acid fibroblast growth factor by prolonging its half-life. J Cell Physiol 138: 221–226, 1989.
  • Davenport RW, McCaig CD. Hippocampal growth cone responses to focally applied electric fields. J Neurobiol 24: 89–100,1993.
  • Davies AM. NGF synthesis and NGF receptor expression in the embryonic mouse trigeminal system. J Physiol Paris 84: 100–103,1990.
  • Davies AM. Role of neurotrophic factors in development. Trends in genetics 4 (5): 139–143,1988.
  • Davies AM, Bandtlow C, Heumann R, Korsching S, Rohrer H, Thoenen H. Timing and site of nerve growth factorsynthesis in developing skin in relation to innervation and expression of the receptor. Nature 326: 353–358, 1987.
  • DeChiara TM, Vej sada R, Poueymirou WT, Acheson A, Suri C, Conover JC, Friedman B, McClain J, Pan L, Stahl N. Mice lacking the CNTFreceptor, unlike mice lacking CNTF, exhibit profound motor neuron deficits at birth. Cell 83: 313–322, 1995.
  • De Felipe C, Pinnock RD, Hunt SP. Modulation of chemotro-pism in the developing spinal cord by substance P. Science 267: 899–902, 1995.
  • De la Torre JR, Kennedy TE, Serafini T, Leonardo ED, Tessier-Lavigne M. Expression pattern of netrins suggests multiple roles in axon guidance and cell migration. Soc Neurosci Abstr 20: 533.20, 1994.
  • De Simone R, Alleva E, Tirassa P, Aloe L. Nerve growth fac-tor released into the bloodstream following intraspecific fighting induces mast cell degranulation in adult male mouse. Brain Behav Immun 4: 74–81, 1990.
  • Deloulme JC, Baudier J, Sensenbrenner M. Establishment of pure neuronal cultures from fetal rat spinal cord and pro-liferation of the neuronal precursor cells in the presence of fibroblast growth factor. J Neurosci Res 29 (4): 499–509, 1991.
  • Diamond J, Foerster A, Holmes M, Coughlin M. Sensory nerves in adult rats regenerate and and restore sensory function to the skin independently of endogenous NGF. J Neurosci 12: 1467–1476, 1992.
  • DiCicco-Bloom E, Friedman WJ, Maltzman JS, Kaplan DR, Black IB. Neurotrophins regulate trkC and trkA receptor expression in developing sympathetic neuroblasts. Soc Neurosci Abstr 20: 109.3, 1994.
  • DiCicco-Bloom E, Wagner JP, Black 113. Brain Derived Neu-rotrophic Factor stimulates rat cerebellar granule neurob-last mitosis in culture. Soc Neurosci Abstr 21: 421.12, 1995.
  • Ding M, Hart RP, Jonakait GM. Tumor necrosis factor a induces substance P in sympathetic ganglia through sequential induction of interleukin-1 and leukemia inhibitory factor. J Neurobiol 28: 445–454, 1995.
  • Dodd J, Schuchardt A. Axon guidance: a compelling case for repelling growth cones. Cell 81: 471–474, 1995.
  • Doré S, Kar S, Rowe W, Quirion R Distribution and levels of [1251IGF-I, [125] IGF-II and [125] insulin binding sites in the hippocampus of aged memory-unimpaired and - impaired rats. Neuroscience 80: 1033–1040, 1997.
  • Du F, Charnay Y, Dubois P. Development and distribution of substance P in the spinal cord and ganglia of embryonic and newly hatched chick: an immunofluorescence study. JComp Neurol 263: 436'154, 1987.
  • Ebendal T. Function and evolution in the NGF gene family and its receptors.JNeurosci Res 32: 461–470.
  • Eckenstein F, Hicks C. The nervous system of basic FGF overexpressing transgenic mice. Soc Neurosci Abstr 20: 538.1, 1994.
  • Eckenstein F, Woodward WR, Nishi R. Different localization and possible functions of aFGF and bFGF in the central and peripheral nervous system. Ann NY Acad Sci 638: 348–360, 1991.
  • Eckenstein FP, Andersson C, Kuzis K, Woodward WR. Dis-tribution of acidic and basic fibroblast growth factors inthe mature, injured and developing rat nervous system. Prog Brain Res 103: 55–63, 1994.
  • Eckenstein FP, Esch F, Holbert T, Blacher RW, Nishi R. Purification and characterization of a trophic factor for embryonic peripheral neurons: comparison with fibroblast growth factors. Neuron 4: 623–631, 1990.
  • Emoto N, Gonzalez AM, Walicke PA, Wada E, Simmons DM, Shimasaki S, Baird A. Basic fibroblast growth factor in the central nervous system: identification of specific loci of basic FGF expression in the rat brain. Growth Fac-tors 2: 21–29, 1989.
  • Engele J, Bohn MC. Effects of acidic and basic fibroblast growth factors on glial precursor cell proliferation: age dependency and brain region specificity. Dev Biol 152 (2): 363–372, 1992.
  • Engele J, Bohn MC. The neurotrophic effects of fibroblast growth factos on dopaminergic neurons in vitro are medi-ated by mesencephalic glia. J Neurosci 11 (10): 3070–3078, 1990.
  • Erkman L, Wuarin L, Cadelli D, Kato AC. Interferon induces astrocyte maturation causing an increase in cholinergic properties of cultured human spinal cord cells. Dev Biol 132: 375–388, 1989.
  • Ernfors P, Ibanez CF, Ebendal T, Olson L, Persson H. Mole-cular cloning and neurotrophic activities of a protein with structure similarities to nerve growth factor: developmen-tal and topographical expression in the brain. Proc Natl Acad USA 87: 5454–5458, 1990a.
  • Ernfors P, Lee KF, Kucera J, Jaenisch R. Lack of neu-rotrophin-3 leads to deficiencies in the peripheral nervous system and loss of limb proprioceptive afferents. Cell 77: 503–512, 1994.
  • Ernfors P, Lonnerberg P, Ayer-Lelievre C, Persson H. Devel-opmental and regional expression of basic fibroblast growth factor mRNA in the rat central nervous system. J Neurosci Res 27: 10–15, 1990b.
  • Ernfors P, Rosario CM, Merlio JP, Grant G, Aldskogius H, Persson H. Expression of mRNAs for neurotrophin recep-tors in the dorsal root ganglion and spinal cord during development and following peripheral or central axotomy. Brain Res Mol Brain Res 17(3-4): 217–226, 1993.
  • Escandon E, Soppet D, Rosenthal A, Mendoza-Ramirez JL, Szonyi E, Burton LE, Henderson CE, Parada LF, Nikolics K. Regulation of neurotrophin receptor expression during embryonic and postnatal development. J Neurosci 14: 2054–2068, 1994.
  • Faik P, Walker JI, Redmill AA, Morgan MJ. Mouse glucose-6-phosphate isomerase and neuroleukin have identical 3' sequences. Nature 332: 455–457, 1988.
  • Fallon JH, DiSalvo J, Loughlin SE, Gimenez-Gallego G, Seroogy KB, Bradshaw RA, Morrison RS, Ciofi P, Thomas KA. Localization of acidic fibroblast growth fac-tor within the mouse brain using biochemical and immunocytochemical techniques. Growth factors 6 (2): 139–157, 1992.
  • Fallon JH, Seroogy KB, Loughlin SE, Morrison RS, Brad-shaw RA, Knaver DJ, Cunningham DD. Epidermal growth factor immunoreactive material in the central ner-vous system: location and development. Science 224 (4653): 1107–1109, 1984.
  • Farinas I, Jones KR, Backus C, Wang XY, Reichardt LF. Severe sensory and sympathetic deficits in mice lacking neurotrophin-3. Nature 369(6482): 658–661.
  • Fazeli A, Dickinson SL, Hermiston ML, Tighe RV, Steen RG, Small CG, Stoeckli ET, Keino-Masu K, Rayburn H, Simons J, Bronson RT, Gordon JI, Tessier-Lavigne M, Weinberg RA. Phenotype of mice lacking functional Deleted in colorectal cancer (Dcc) gene. Nature 386: 796–804, 1997.
  • Feij en A, Goumans MJ, van den Eijnden-van Raaij AJ. Expression of activin subunits, activin receptors and fol-listatin in postimplantation mouse embryos suggests spe-cific developmental functions for different activins. Development 120 (12): 3621–3637.
  • Ferrari G, Toffano G, Skaper SD. Epidermal growth factor exerts neuronotrophic effects on dopaminergic and GAI3Aergic CNS neurons: comparison with basic fibrob-last growth factor. J Neurosci Res 30(3): 493–497, 1991.
  • Figueiredo BC, Pliiss K, Skup M, Often U, Cuello AC. Acidic FGF induces NGF and its mRNA in the injured neocortex of adult animals. Mol Brain Res 33: 1–6, 1995.
  • Flanders KC, Ludecke G, Engels S, Cissel DS, Roberts AB, Kondaiah P, Lafyatis R, Sporn MB, Unsicker K. Local-ization and actions of transforming growth factor Ps in the embryonic nervous system. Development 113 (1): 183–191, 1991.
  • Forssman J. Ueber die Ursachen, welche die Wachsthum-srichtung der periferen nervenfasern bei der Regeration bestimmen. Beitr Pathol Anat Allg Pathol 24: 56–100, 1898.
  • Freed WJ. The role of nerve growth factor in the central ner-vous system. Brain Res Bull]: 393–412, 1976.
  • Friedman WJ, Ernfors P. Persson H. Transient and persistent expression of NT-3/HDNF mRNA in the rat brain during postnatal development. J Neurosci 11 (6): 1577–1584, 1991.
  • Friedman WJ, Ibanez CF, Hallb88k F, Persson H, Cain LD, Dreyfus CF, Black IB. Differential actions of neu-rotrophins in the locus coeruleus and basal forebrain. Exp Neuro1119: 72–78, 1993.
  • Funakoshi H, Belluardo N, Arenas E, Yamamoto Y, Casabona A, Persson H, Ibanez CF. Muscle-derived neu-rotrophin-4 as an activity-dependent trophic signal for adult motoneurons. Science 268 (5216): 1495–1499, 1995.
  • Gadient RA, Often U. Differential expression of interleukin-6 and interleukin-6 receptor in rat hippocampus. Neuro-science letters 153: 13–16, 1993.
  • Gadient RA, Otten UH.Interleukin-6 and interleukin-6 recep-tor mRNA expression in rat central nervous system. Ann N Y Acad Sci 762: 403–406,1995.
  • Galko MJ, Serafini T, Tessier-Lavigne M. Identification and characterization of a netrin synergizing activity. Soc Neu-rosci Abstr 20: 533.19, 1994.
  • Gao WQ, Zheng JL, Karihaloo M. Neurotrophin-4/5 and brain-derived neurotrophic factor act at late stages of cerebellar granule cell differentation. J Neurosci 15 (4): 2656–2667, 1995.
  • Gaul G, Lubbert H. Cortical astrocytes activated by basic fibroblast growth factor secrete molecules that stimulate differentiation of mesencephalic dopaminergic neurons. Proc R Soc Lond B Biol Sci 249 (1324): 57–63, 1992.
  • Gebicke-Haerter PJ, Appel K, Taylor GD, Schobert A, Rich IN, Northoff H, Berger M. Rat microglia interleukin-3. J Neuroimmunol 50(2): 203–214, 1994.
  • Gensburger C, Capo M, Deloulme JC, Sensenbrenner M. Influence of basic fibroblast growth factor on the develop-ment of cholinoceptive neurons from fetal rat cerebrum in culture. Dev Neurosci 14(4): 278–281, 1992.
  • Gensburger C, Labourdette G, Sensenbrenner M. Brain basic fibroblast growth factor stimulates the proliferation of rat neuronal precursor cells in vitro. FEBS letters 217: 1–5, 1987.
  • Gensburger C, Labourette G, Sensenbrenner M. Effet du FGF basique sur la proliferation de neuroblast de rat en culture. C R Acad Sci 111 303: 465–468, 1986.
  • Giacobini MM, Almstrom S, Funa K, Olson L. Differential effects of platelet-derived growth factor isoforms on dopamine neurons in vivo: -BB supports cell survival, - AA enhances fiber formation. Neuroscience 57: 923–929, 1993c.
  • Giacobini MM, Olson L, Hoffer BJ, Sara VR. Truncated IGF-I exerts trophic effects on fetal brain tissue grafts. Exp neuro1108: 33–37, 1990.
  • Giacobini MM, Smits A, Funa K, Westermark B, Olson L. Differential effects of platelet-derived growth factors on fetal hippocampal and cortical grafts: evidence from intraocular transplantation in rats. Neuroscience letters 136: 227–231, 1992.
  • Giacobini MM, Stromberg I, Almstrom S, Cao Y, Olson L. Fibroblast growth factor enhance dopamine fiber forma-tion from nigral grafts. Brain Res Dev Brain Res 75: 65–73, 1993a.
  • Giacobini MMJ, Hoffer B, Olson L. Fibroblast growth fac-tors influence central nervous system development: evi-dence from intraocular grafts. Ann NY Acad Sci 638: 48/1 /186, 1991.
  • Giacobini MMJ, Zetterstrom R, Sara V, Olson L. Differentail effects of insulin-like grwoth factor-I in the developing rat olfactory bulb and cerebral cortex. Ann NY Acad Sci 692: 294–296, 1993b.
  • Giger RJ, Wolf DP, De Wit GM, Verhaagen J. Anatomy of rat semaphorin IIUcollapsin -1 mRNA expression and rela-tionship to developing nerve tracts during neuroembryo-genesis. J Comp Neurol 375: 378–392, 1996.
  • Gimenez-Gallego G, Rodkey J, Bennett C, Rios-Candelore M, DiSalvo J, Thomas K. Brain-derived acidic fibroblast growth factor: complete amino acid sequence and homologies. Science 230: 1385–1388, 1985.
  • Giulian D, Allen RL, Baker TJ, Tomozawa Y. Brain peptides and glial growth. Glia-promoting factors as regulators in the developing and injured central nervous system. J Cell Bio1102: 803–811, 1986.
  • Giulian D, Young DG, Woodward J, Brown DC, Lachman LB. Interleukin-1 is an astroglial growth factor in the developing brain.JNeurosci 8 (2): 709–714, 1988.
  • Gnahn H, Hefti F, Heumann R, Schwab ME, Thoenen H. NGF-mediated increase of choline acetyltransferase in the neonatal rat forebrain: evidence for a physiological role of NGF in the brain? Dev Brain Res 9: 45–52, 1983.
  • Godement P, Salaiin J, Mason CA. Retinal axon pathfindin-gin the optic chiasm: divergence of crossed and uncrossed fibers. Neuron 5: 173–186, 1990.
  • Gomez-Pinilla F, Gotman CW. Distribution of fibroblast growth factor 5 mRNA in the rat brain: an in situ hybridization study. Brain Res 606: 79–86, 1993.
  • Gomez-Pinilla F, Knauer DJ, Nieto-Sampedro M. Epidermal growth factor receptor immunoreactivity in rat brain. Development and cellular localization. Brain Res 438: 385–390, 1988.
  • Gomez-Pinilla F, Lee JW, Cotman CW. Distribution of basic fibroblast growth factor in the developing rat brain. Neu-roscience 61 (4): 911–923, 1994.
  • Gomez-Pinilla F, Vu L, Cotman CW. Regulation of astrocyte proliferation by FGF-2 and heparan sulfate in vivo. J Neu-rosci 15 (3): 2021–2029, 1995.
  • Goodman CS. The likeness of being: phylogenetically con-served molecular mechanisms of growth cone guidance. Cell 78: 353–356, 1994.
  • Go:Az R, Koster R, Winkler C, Raulf F, Lottspelch F, Scharff M, Thoenen H. Neurotrophin-6 is a new member of the nerve growth factor family. Nature 372: 266–269, 1994.
  • Griesbeck 0, Parsadanian AS, Sendtner M, Thoenen H. Expression of motoneurons in skeletal muscle: quantita-tive comparison and significance for motoneuron survival and maintenance of function. J Neurochem Res 42: 21–33, 1995.
  • Grothe C, Zachmann K, Unsicker K. Basic FGF-like immunoreactivity in the developing and adult rat brain-stem. J Comp Neurol 305 (2): 328–336, 1991.
  • Gundersen RW, Barret JN. Neuronal chemotaxis: chick dor-sal-root axons turn toward high concentration of NGF. Science 206: 33–37, 1979.
  • Gundersen RW, Barrett JN. Characterization of the turning response of dorsal root neurites toward nerve growth fac-tor. J Cell Biol 87: 546–554, 1980.
  • Gurney ME, Heinrich SP, Lee MR, Yin HS. Molecular cloning and expression of neuroleukin, a neurotrophic fac-tor for spinal and sensory neurons. Science 234: 566–574, 1986.
  • Hagg T, Varon S. Neurotropism of nerve growth factor for adult septal cholinergic axons in vivo. Exp Neurol 119: 37–45, 1993.
  • Haglid KG, Hansson HA, Ronnback L. S-100 in the central nervous system of rat, rabbit and guinea pig during post-natal development. Brain Res 123: 331–345, 1977.
  • Hall AK, Rao MS. Cytokines and neurokines: related ligands and related receptors. Trends Neurosci 15: 35–37, 1992.
  • Hallbook F, Ibanez CF, Ebendal T, Persson H. Cellular local-ization of brain derived neurotrophic factor and neu-rotrophin-3 mRNA expression in the early chicken embryo. Eur J Neurosci 5: 1–14, 1993.
  • Hallbook F, Ibnez CF, Persson H. Evolutionary studies of the nerve growth family reveal a novel member abundantly expressed in Xenopus ovary. Neuron 6: 845–858, 1991.
  • Hamburger V. History of the discovery of neuronal death in embryos. J Neurobiol 23 (9): 1116–1123, 1992.
  • Hamburger V. S. Ramon y Cajal, R.G. Harrison, and the beginnings of neuroembryology. Perspectives in biology and medicine 23(4): 600–616, 1980.
  • Hamburger V. The history of the discovery of the nerve growth factor. J Neurobiol 24: 893–897, 1993.
  • Hamburger V, Levi-Montalcini R. Some aspects of neuroem-bryology. In: Genetic neurology, edited by P. Weiss, Chicago 1950.
  • Hansson HA. Insulin-like growth factors and nerve regener-ation. Ann NY Acad Sci 692:161–171, 1993.
  • Hantzopoulos PA, Sun i C, Glass DJ, Goldfarb MP, Yan-copoulos GD. The low affinity NGF receptor, p75, can collaborate with each of the Trks to potentiate functional responses to the neurotrophins. Neuron 13: 187–201, 1994.
  • Harrison R. The outgrowth of the nerve fiber as a mode of protoplasmic movement. J Exp Zool 9: 787–848, 1910.
  • Hartikka J, Hefti F. Comparison of nerve growth factor's effects on development of septum, striatum, and nucleus basalis cholinergic neurons in vitro. J Neurosci Res 21: 352–364, 1988.
  • He Z, Tessier-Lavigne M. Neuropilin is a receptor for the axonal chemorepellent semaphorin III. Cell 90: 739–751, 1997.
  • Hedgecock EM, Culotti JG, Hall DH. The unc-5, unc-6, and unc-40 genes guide circumferential migrations of pioneer axon migrations in C. elegans. Neuron 4: 61–85, 1990.
  • Heikinheimo M, Lawshe A, Shackleford GM, Wilson DB, MacArthur CA. FGF-8 expression in the post-gastrulation mouse suggest roles in the development of the face, limbs and central nervous system. Mech Dev 48 (2): 129–138, 1994.
  • Hempstead BL, Martin-Zanca D, Kaplan DR, Parada LF, Chao MV. High-affinity NGF expression requires coex-pression of the trk proto-oncogene and the low-affinity NGF receptor. Nature 330: 678–683, 1991.
  • Henderson CE, Phillips HS, Pollock RA, Davies AM, Lemeulle C, Armanini M, et al. GDNF: a potent survival factor for motoneurons present in peripheral nerve and muscle. Science 266: 1062–1064, 1994.
  • Henderson CE, Camu W, Mettling C, Gouin A, Poulsen K, Karihaloo M, Rullamas J, Evans T, McMahon SB, Armanini MP, Berkemeier L, Phillips HS, Rosenthal A. Neurotrophins promote motor neuron survival and are present in embryonic limb bud. Nature 363: 266–270, 1993.
  • Henderson JT, Seniuk NA, Richardson PM, Roder JC. Effects of overexpressing of CNTF in the CNS. Soc Neurosci Abstr 20: 451.11, 1994.
  • Heuer JG, von Barthfeld CS, Kinoshita Y, Evers PC, Both-well M. Alternating phases of FGF receptor and NGF receptor expression in the developing chicken nervous system. Neuron 5: 283–296, 1990.
  • Hill MA, Bennett MR. Cholinergic growth factor from scele-tal muscle elevated following denervation. Neurosci Let-ters 35: 31–35, 1983.
  • Hohn A, Leibrock J, Bailey K, Barde YA. Identification and characterization of a novel member of the nerve growth factor/brain derived neurotrophic factor family. Nature 344: 339–341, 1990.
  • Holtzman DM, Killbridge J, Li Y, Cunningham ET, Lenn NJ, Clary DO, Reichardt LF, Mobley WC. TrkA expression in the CNS: evidence for the existence of several novel NGF-
  • responsive CNS neurons. J Neurosci 15: 1567–1576, 1995. Honegger P, Lenoir D. Nerve growth factor stimulation of cholinergic telencephalic neurons in aggregating cell cul-tures. Dev Brain Res 3: 229–238, 1982.
  • Houenou LJ, Li L, Lo AC, Yan Q, Oppenheim RW. Naturally occuring and axotomy-induced motoneuron death and its prevention by neurotrophic agents: a comparison between chick and mouse. Frog Brain Res 102: 217–226, 1994.
  • Hughes RA, Sendtner M, Goldfarb M, Lindholm D, Thoenen H. Evidence that fibroblast growth factor 5 is a major muscle-derived survival factor for cultured spinal motoneurons. Neuron 10: 369–377, 1993a.
  • Hughes RA, Sendtner M, Thoenen H. Members of several gene families influence survival of rat motoneurons in vitro and in vivo. J Neurosci Res 36: 663–671, 1993b.
  • Hughes SM, Lillien LE, Raff MC, Rohrer H, Sendtner M. Ciliary neurotrophic factor induces type-2 astrocyte dif-ferentiation in culture. Nature 335: 70–73, 1988.
  • Hurwitz AA, Lyman WD, Guida MP, Calderon TM, Berman JVV. Tumor necrosis factor a induces adhesion molecule expression on human fetal astrocytes. J Exp Med 176(6): 1631–1636, 1992.
  • Hutchins JB, Jefferson VE. Developmental distribution of platelet-derived growth factor in the mouse central ner-vous system. Brain Res Dev Brain Res 67: 121–135, 1992.
  • Hyman C, Hofer M, Barde YA, Juhasz M, Yancopoulos GD, Squinto SP, Lindsay RM. BDNF is a neurotrophic factor for dopaminergic neurons of the substantia nigra. Nature 350: 230–232, 1991.
  • Hyman C, Juhasz M, Jackson C, Wright P, Ip NY, Lindsay RM. Overlapping and distinct actions of the neurotrophins BDNF, NT-3, and NT-4/5 on cultured dopaminergic and GAI3Aergic neurons of the ventral mesencephalon. J Neu-rosci 14: 335–347, 1994.
  • Hynes MA, Poulsen K, Armanini M, Berkemeier L, Phillips H, Rosenthal A. Neurotrophin-4/5 is a survival factor for embryonic midbrain dopaminergic neurons in enriched cultures. J Neurosci Res 37: 144–154, 1994.
  • Ibanez CF, Ernfors P, Timmusk T, Ip NY, Arenas E, Yan-copoulos GD, Persson H. Neurotrophin-4 is a target-derived neurotrophic factor for neurons of the trigeminal ganglion. Development 117: 1345–1353, 1993.
  • Inagaki S, Furuyama T, Iwahashi Y. Identification of a mem-ber of mouse semaphorin family. FEBS letters 370: 269–272, 1995.
  • Ip NY, Ibanez CF, Nye SH, McClain J, Jones PF, Gies DR, Bellusco L, Le Beau MM, Espinosa R, Squinto SP. Mam-malian neurotrophin-4: structure, chromosomal localiza-tion, tissue distribution, and receptor specificity. Proc Natl Acad Sci USA 89: 3060–3064, 1992.
  • Ip NY, McClain J, Barrezueta NX, Aldrich TH, Pan L, Li Y, Wiegand SJ, Friedman B, Davis S, Yancopoulos GD. The a component of the CNTF receptor is required for signal-ing and defines potential CNTF targets in the adult and during development. Neuron 10: 89–102, 1993.
  • Ip NY, Yancopoulos, GD. Ciliary neurotrophic factor and its receptorcomplex. Frog Growth Factor Res 4 (2): 139–155, 1992.
  • Ishii N, Wadsworth WG, Stern BD, Culotti JG, Hedgecock EM. UNC-6, a laminin-related protein, guides cell and
  • pioneer axon migrations in C. elegans. Neuron 9: 873–881, 1992.
  • Jacobs J, Waziri R, Miller MW. Immunohistochemical evi-dence of nerve growth factor and neurotrophin receptors (trk and p75) in the trigeminal brain stem of adult rats. Soc Neurosci Abstr 20: 23.3, 1994.
  • Jakowlew SB, Ciment G, Tuan RS, Sporn MB, Roberts AB. Expression of transforming growth factor 13 2 and 13 3 mRNAs and proteins in the developing chicken embryo. Differentiation 55 (2): 105–118, 1994.
  • Johnson MD, Jennings MT, Gold LI, Moses HL. Transform-ing growth factor 13 in neural embryogenesis and neopla-sia. Hum Pathol 24 (5): 457–462, 1993.
  • Jonakait GM, Wei R, Sheng ZL, Hart RP, NI L. Interferon-gamma promotes cholinergic differentiation of embryonic septal nuclei and adjacent basal forebrain. Neuron 12: 1149–1159, 1994.
  • Jones CM, Lyons KM, Hogan BL. Involvement of Bone Mor-phogenetic Protein-4 (BMP-4) and Vgr-1 in morphogen-esis and neurogenesis in mouse. Development 111 (2): 531–542, 1991.
  • Joosten EAJ, Bar PR, Gispen WH, Bregman BS. Transient projections from rat occipital cortex are able to respond to a spinal target-derived diffusible factor in vitro. Neuro-science letters 164: 85–88, 1993.
  • Kahane N, Kalcheim C. Expression of trkC receptor mRNA during development of the avian nervous system. J Neu-robiology 25 (5): 571–584, 1994.
  • Kahane N, Shelton D, Kalcheim C. Expression and regula-tion of brian-derived neurotrophic factor and neu-rotrophin-3 mRNA in distinct avian motoneuron subsets. J Neurobiol 29: 277–292, 1996.
  • Kaisho Y, Shintani A, Ono Y, Kato K, Igarashi K. Regional expression of nerve growth family gene family in rat brain during development. Biochim Biophys Res Comm 174: 379–385, 1991.
  • Kamegai M, Miijima K, Kunishita T, Nishizawa M, Ogawa M, Araki M, Ueki A, Konishi Y, Tabira T. Interleukin 3 as atrophic factor for central cholinergic neurons in vitro and in vivo. Neuron 4: 429–436, 1990.
  • Kar S, Seto D, Hanisch UK, Quirion R. Insulin-like growth factors I and II: receptor localization and effects on acetyl-choline release in the rat hippocampus. Soc Neurosci Abstr 20: 40.5, 1994.
  • Kato AC, Lindsay RM. Overlapping and additive effects of neurotrophins and CNTF on cultured human spinal cord neurons. Exp Neurol 130 (2): 196–201, 1994.
  • Keino-Masu K, Masu M, Hinck L, Leonardo ED, Chan SS, Culotti JG, Tessier-Lavigne M. Deleted in colorectal can-cer (Dcc) encodes a netrin receptor. Cell 87: 175–185, 1996.
  • Kenigberg RL, Mazzoni IE, Collier B, Cuello AC. Epidermal growth factor affects both glia and cholinergic neurons in septal cell cultures. Neuroscience 50 (1): 85–97, 1992.
  • Kennedy TE, Serafini T, de la Torre JR, Tessier-Lavigne M. Netrins are diffusible chemotropic factors for commisural axons in the embryonic spinal cord. Cell 78: 425–435, 1994.
  • Kennedy TE, Tessier-Lavigne M. Guidance and induction of branch formation in developing axons by target-derived diffusible factors. Current Opin Neurobiol 5: 83–90, 1995.
  • Kitsukawa T, Simizu M, Sanbo M, Hirata T, Taniguchi M, Bekku Y, Yagi T, Fujisawa H. Neuropilin-semaphorin IIUD-mediated chemorepulsive signals play a crucial role in peripheral nerve projection in mice. Neuron 19: 995–1005, 1997.
  • Klein R. Role of neurotrophins in mouse neuronal develop-ment. Faseb J 8 (10): 738–744, 1994.
  • Klein R, Jing S, Nanduri V, O'Rourke E, Barbacid M. The trk proto-oncogene encodes a receptor for nerve growth fac-tor. Cell 85: 185–197, 1991.
  • Klein R, Martin-Zanca D, Barbacid M, Parada LF. Expres-sion of the tyrosine kinase receptor gene trkB is confined to the murine embryonic and adult nervous system. Development 4: 845–850, 1990.
  • Klein R, Silos-Santiago I, Smeyne RJ, Lira SA, Brambilla R, Bryant S, Zhang L, Snider WD, Barbacid M. Disruption of the neurotrophin-3 receptor gene trkC eliminates Ia muscle afferents and results in abnormal movement. Nature 368: 249–251, 1994.
  • Klein R, Smeyne RJ, Wurst W, Long LK, Auerbach BA, Joyner AL, Barbacid M. Targeted disruption of the trkB neurotrophin receptor results in nervous system lesions and neonatal death. Cell 75: 113–122, 1993.
  • Klingman G. Catecholamine levels and dopa decarboxylase activity in peripheral organs and adrenergic tissues in the rat after immunosympathectomy. J Pharmac exp Ther 148: 14–21, 1965.
  • Kniisel B, Winslow JVV, Rosenthal A, Burton LE, Seid DP, Nikolics K, Hefti F. Promotion of central cholinergic and dopaminergic neuron differentiation by brain-derived neu-rotrophic factor but not neurotrophin 3. Proc Natl Acad Sci 88: 961–965, 1991.
  • Kokaia Z, Metsis M, Kokaia M, Elmer E, Lindvall 0. Co-expression of trkB and trkC receptors in CNS neurons suggest regulation by multiple neurotrophins. Neuro report 6: 769–772, 1995.
  • Koliatsos VE, Cayouette MH, Berkemeier LR, Clatterbuck RE, Price DL, Rosenthal A. Neurotrophin 4/5 is atrophic factor for mammalian facial motoneurons. Proc Natl Acad Sci USA 91 (8): 3304–3308, 1994.
  • Koliatsos VE, Shelton DL, Mobley WC, Price DL. A novel group of nerve growth factor receptor-immunoresponsive neurons in the ventral horn of the lumbar spinal cord. Brain Res 541: 121–128, 1991.
  • Kolodkin AL, Levengood DV, Rowe EG, Tai YT, Giger RJ, Ginty DD. Neuropilin is a semaphorin III receptor. Cell 90: 753–762, 1997.
  • Kolodkin AL, Matthes DJ, Goodman CS. The semaphorin genes encode a family of transmembrane and secreted growth cone guidance molecules. Cell 75: 1389–1399, 1993.
  • Kolodkin AL, Matthes DJ, O'Connor TP, Patel NH, Bentley D, Goodman CS. Fasciclin IV: sequence, expression, and function during growth cone guidance in the grasshopper embryo. Neuron 9: 831–845, 1992.
  • Kornblum HI, Raymon HK, Morrison RS, Cavanaugh KP, Bradshaw RA, Leslie FM. Epidermal growth factor and basic fibroblast growth factor: effects on an overlapping
  • population of neocortical neurons in vitro. Brain Res 535 (2): 255–263, 1990.
  • Korsching S. The neurotrophic factor concept: a reexamina-tion. J Neurosci 13 (7): 2739–2748, 1993.
  • Korsching S, Auburger G, Heumann R, Scott J, Thoenen H. Levels of nerve growth factor and its mRNA in the central nervous system of the rat correlate with cholinergic inner-vation. EMBO J 4: 1389–1393, 1985.
  • Kozlova MV, Ilyinski OB, Kalentchuk VU, Kondrikova ES. Stimulatory effect of substance P on sympathetic ganglia and spinal cord in culture. Neurosci Letters 82: 16–20, 1987.
  • Kromer LF, Barbacid M, Smeyne RJ. Mice lacking trkA receptors fail to maintain a normal organization of their basal forebrain cholinergic projections. Soc Neurosci Abstr 20: 109.6, 1994.
  • Kudlow JE, Leung AWC, Kobrin MS, Paterson AJ, Asa SL. Transforming growth factor a in the mammalian brain. J Biol Chem 264 (7): 3880–3893, 1989.
  • Kushima Y, Hatanaka H. Interleukin-6 and leukemia inhibitory factor promote the survival of acetyl-cholinesterase-positive neurons in culture from embryonic rat spinal cord. Neuroscience letters 143: 110–114, 1992.
  • Kwon YW, Abbonanzo SJ, Stewart CL, Gurney ME. Leukemia inhibitory factor influences the timing of pro-grammed synapse withdrawal from neonatal muscles. J Neurobiol 28: 35–50, 1995.
  • Lamballe F, Klein R, Barbacid M. TrkC, a new member of the trk family of tyrosine protein kinases, is a receptor for neurotrophin-3. Cell 66: 967–979, 1993.
  • Large TH, Bodary SH, Clegg DO, Weskamp G, Otten U, Reichardt LF. Nerve growth factor gene expression in the developing rat brain. Science 234: 352–355, 1986.
  • Lee KF, Li E, Huber LJ, Landis SC, Sharpe AH, Chao MV, Jaenisch R. Targeted mutation of the gene encoding the low affinity NGF receptor p75 leads to deficits in the peripheral sensory nervous system. Cell 69: 737–749, 1992.
  • Lee SC, Liu W, Brosnan CF, Dickson W. GM-CSF promotes proliferation of human featl and adult microglia in pri-mary cultures. Glia 12 (4): 309–318, 1994.
  • Lee SC, Liu W, Dickson DW, Brosnan CF, Berman JW. Cytokine production by human fetal microglia and astro-cytes. Different induction by lipopolysaccharide and IL-113. J Immunol 150 (7): 2659–2667, 1993.
  • Leibrock J, Lottspreich F, Hohn A, Hofer M, Hengerer B, Masiakowski P, Thoenen H, Barde YA. Molecular cloning and expression of brain-derived neurotrophic factor. Nature 341: 149–152, 1989.
  • Lemmon V, Burden SM, Payne HR, Elmslie GJ, Hlavin ML. Neurite growth on different substrates: permissive versus instructive influences and the role of adhesive strength. J Neurosci 12: 818–826, 1992.
  • Leon A, Buriani A, Dal Toso R, Fabris M, Romanello S, Aloe L, Levi-Montalcini R. Mast cells synthesize, store, and release nerve growth factor. Proc Natl Acad USA 91: 3739–3743, 1994.
  • LeRoith D, Roberts CT. Insulin-like growth factors. Ann NY Acad Sci 692: 1–9, 1993.
  • LeRoith D, Werner H, Faria TN, Kato H, Adamo M, Roberts CT. Insuline-like growth factor receptors. Implications for
  • nervous system function. Ann NY Acad Sci 629: 22–32, 1993.
  • Levi-Montalcini R. The nerve growth factor 35 years later. Science 237: 1154–1162, 1987.
  • Levi-Montalcini R, Angeletti PU. Immunosympathectomy. Pharmac Rev 18: 619–628, 1966.
  • Levi-Montalcini R, Booker B. Destruction of the sympathetic ganglia in mammals by an antiserum to the nerve growth promoting factor. Proc Natl Acad Sci USA 42: 384–391, 1960.
  • Li B, Dai W. Trombopoietin and neurotrophins share a com-mon domain. Blood 84 (4): 1643–1644, 1995.
  • Li X, Franz J, Lottspeich F, Gotz R. Recombinant fish neu-rotrophin-6 is a heparin-binding glycoprotein: implica-tions for a role in axonal guidance. Biochem J 324: 4661–466, 1997.
  • Liesi P, Silver J. Is astrocyte laminin involved in axon guid-ance in the mammalian CNS? Dev Biol 130: 774–785, 1988.
  • Lillien LE, Sendtner M, Raff MC. Extracellular matrix-asso-ciated molecules collaborate with ciliary neurotrophic fac-tor to induce type-2 astrocyte development. J Cell Biol 111 (2): 635–644, 1990.
  • Lin LF, Doherty DH, Lile JD, Bektesh S, Collins F. GDNF: a glial cell-line derived neurotrophic factor for midbrain dopaminergic neurons. Science 260 (5111): 1130–1132, 1993.
  • Lindholm D, Hartikka J, da Penha Berzaghi M, Castren E, Tzimagiorgis G, Hughes RA, Thoenen H. Fibroblast growth factor-5 promotes differentiation of cultured rat septal cholinergic and raphe serotonergic neurons: com-parison with the effects of neurotrophins. Eur J Neurosci 6: 244–252, 1994.
  • Lindqvist E, Tomac A, Luthman J, Hoffer B, Bektesh S, Olson L. Distribution of Glial cell line Derived Neu-rotrophic Factor (GDNF) during pre- and postnatal development in rat central and peripheral tissues. Soc Neurosci Abstr 20: 454.13, 1994.
  • Liu JP, Lauder JM. S100(3 and insulin-like growth factor-II differentially regulate growth of developing serotonin and dopamine neurons in vitro. J Neurosci Res 33: 248–256, 1992.
  • Liu X, Ernfors P, Wu H, Jaenisch R. Sensory but not motor neuron deficits in mice lacking NT4 and BDNF. Nature 375: 238–241, 1995.
  • Lorenzi MV, Knusel B, Hefti F, Strauss WC. Nerve growth factor regulation of choline acetyltransferase gene expres-sion in rat embryo basal forebrain cultures. Neurosci Lett 140: 185–188, 1992.
  • Louis JC, Magal E, Takayama S, Varon S. CNTF protection of oligodendrocytes against natural and tumor necrosis factor-induced death. Science 259 (5095): 689–692, 1993.
  • Lumsden AG, Davies AM. Chemotropic effect of specific tar-get epithelium in the developing mammalian nervous sys-tem. Nature 323: 538–539, 1986.
  • Luo Y, Raible D, Raper JA. Collapsin: a protein in the brain that induces the collapse and paralysis of growth cones. Cell 75: 217–227, 1993.
  • Luo Y, Shepherd I, Li J, Renzi MJ, Chang S, Raper JA. Afamily of molecules related to collapsin in the embryonic chick nervous system. Neuron 14: 1131–1140, 1995 .
  • Mabie PC, Mehler MF, Kessler JA. Effects of Bone Morpho-genetic Protein 2 on rat embryonic ventral mesencephalon in vitro. Soc Neurosci Res 20: 285.4, 1994.
  • Magal E, Burnham P, Varon S. Effects of ciliary neurotrophic factor on rat spinal cord neurons in vitro: survival and expression of choline acetyltransferase and low affinity nerve growth factor receptors. Dev Brain Res 63: 141–150, 1991.
  • Maisonpierre PC, Belluscio L, Friedman B, Alderson RF, Wiegand SJ, Furth ME, Lindsay RM, Yancopoulos GD. NT-3, BDNF, and NGF in the developing rat nervous sys-tem: parallel as well as reciprocal patterns of expression. Neuron 5: 501–509, 1990.
  • Majdan M, Lachance C, Gloster A, Aloyz R, Zeindler C, Bamji S, Bhakar A, Belliveau D, Fawcett J, Miller FD, Barker PA. Transgenic mice expressing the intracellular domain of the p75 neurotrophin receptor undergo neu-ronal apoptosis. J Neurosci 17: 6988–6998, 1997.
  • Maki Y, Narumi S. Stimulatory effect of substance P on neu-rite extension and cyclic AMP levels in cultured neurob-lastoma cells. J Neurochem 30: 1321–1326, 1978.
  • Martinou JC, Le Van Thai A, Valette A, Weber MJ. Trans-forming Growth Factor 13 is a potent survial factor for rat embryo motoneurons in culture. Dev Brain Res 52: 175–181, 1991.
  • Martinou JC, Martinou I, Kato AC. Cholinergic differentia-tion factor (CDF/LIF) promotes survival of isolated rat embryonic neurons in vitro. Neuron 8: 737–744,1992.
  • Mason IJ. The ins and outs of Fibroblast Growth Factors. Cell 78: 547–552, 1994.
  • Masu Y, Wolf E, Hohmann B, Sendtner M, Brem G, Thoenen H. Disruption of the CNTF gene results in motor neuron degeneration. Nature 365: 27–32, 1993.
  • Matsuoka I, Kobayashi M, Kurihara K. Bone Morphogenetic Protein-2 and retinoic acid induce trkC receptor in cul-tured neurons. Soc Neurosci Abstr 21: 422.19, 1995.
  • Matsuoka I, Kobayashi M, Kurihara K. Differential regula-tion of neurotrophin receptor expression in cultured sym-pathetic neurons by retinoic acid. Soc Neurosci Abstr 20: 24.14, 1994.
  • Matthes DJ, Sink H, Kolodkin AL, Goodman CS. Sema-phorin II can function as a selective inhibitor of specific synaptic arborizations. Cell 81: 631–639, 1995.
  • Mazzoni IE, Kenigberg RL. Transforming growth factor a differentially affects GABAergic and cholinergic neurons in rat medial septal cell cultures. Brain Res 707: 88–99, 1996.
  • Mazzoni IE, Kenigsberg RL. Localization and characteriza-tion of epidermal growth-factor receptors in the develop-ing rat medial septal area in culture. Brain Res 656 (1): 115–126, 1994.
  • McCaig CD. Electric fields, contact guidance and the direc-tion of nerve growth. J Embryol Exp Morphol 94: 245–255, 1986.
  • McManaman IL, Oppenheim RW, Prevette D, Marchetti D. Rescue of motoneurons from cell death by a purified skeletal muscle polypeptide: effects of the ChAT develop-ment factor, CDF. Neuron 4 (6): 891–898, 1990.
  • McMorris FA, Dubois-Dalcq M. Insulin-like growth factor I promotes cell proliferation and oligodendroglial commit-ment in rat glial progenitor cells developing in vitro. J Neurosci Res 21: 199–209, 1988.
  • Mehler MF, Rozental R, Dougherty M, Spray DC, Kessler JA. Cytokine regulation of neuronal differentiation of hip-pocampal progenitor cells. Nature 362: 62–65, 1993.
  • Meier E, Hansen GH, Schousboe A. The trophic effect of GABA on cerebellar granule cells is mediated by GAI3A receptors. Int J Dev Neurosci 3: 401–407, 1985.
  • Mennicken F, Quiron R. Interleukin-2 increases choline acetyltransferase activity in septal cell cultures. Synapse 26: 175–183, 1997.
  • Messersmith EK, Leonardo ED, Shatz CJ, Tessier-Lavigne M, Goodman CS, Kolodkin AL. Semaphorin II can func-tion as a selective chemorepellent to pattern sensory pro-jections in the spinal cord. Neuron 14: 949–959, 1995.
  • Metsis M, Salin T, Hurd Y, Timmusk T. Structure and trans-genic expression of rat neurotrophin-4 gene. Soc Neurosci Abstr 20: 451.10, 1994.
  • Michael GJ, Kaya E, Averill S, Rattray M, Clary DO, Priestly JV. TrkA immunoreactive neurons in the rat spinal cord. J Comp Neurol 385: 441–455, 1997.
  • Michiwaka M, Kikuchi S, Kim SU. Leukemia inhibitory fac-tor (LIE) mediated increase of choline transferase activity in mouse spinal cord neurons in culture. Neuroscience let-ters 140 (1): 75–77, 1992.
  • Mignatti P. Morimoto T, Rifkin DB. Basic fibroblast growth factor, a protein devoid of secretory signal sequence, is released by cells via a pathway independent of the endo-plasmatic reticulum-Golgi complex. J Cell Physiol 151: 81–93, 1992.
  • Mitchell KJ, Doyle J, Tear G, Serafini T, Kennedy TE, Mirzyan C, Tessier-Lavigne M, Goodman CS. Genetic analysis of growth cone axon guidance at the midline of the Drosophila: expression and function of D-netrin. Soc Neurosci Abstr 20: 439.7, 1994.
  • Mizuno K, Carnahan J, Nawa J. Brain-derived neurotrophic factor promotes differentiation of striatal GAI3Aergic neu-rons. Dev Biol 165 (1): 243–256, 1994a.
  • Mizuno T, Sawada M, Suzumura A, Marunouchi T. Expres-sion of cytokines during glial differentiation. Brain Res 656: 141–146, 1994b.
  • Mobley WC, Rutkowski JL, Tennekoon GI, Buchanan K, Johnston MV. Choline acetyltransferase activity in the striatum of neonatal rats increased by nerve growth factor. Science 229: 284–287, 1985.
  • Morfini G, DiTella MC, Feiguin F, Cam N, Caceres A. Neu-rotrophin-3 enhances neurite ougrowth in cultured hip-pocampal pyramidal neurons. J Neurosci Res 39: 219–232, 1994.
  • Morrison RS. Fibroblast growth factors: potential neu-rotrophic agents in the central nervous system. J Neurosci Res 17: 99–101, 1987.
  • Morrison RS, Keating RF, Moskal JR. Basic fibroblast growth factor and epidermal growth factor exert differen-tial trophic effects on CNS neurons. J Neurosci Res 21 (1): 71–79, 1988.
  • Morrison RS, Kornblum HI, Leslie FM, Bradshaw RA. Trophic stimulation of cultured neurons from neonatalbrain by epidermal growth factor. Science 238 (4823): 72–75, 1987.
  • Morshead CM, van der Kooy D. Postmitotic death is the fate of constitutively proliferating cells in the subependymal layer of the adult mouse brain. J Neuroscience 12 (1): 249–256, 1992.
  • Mozell R, Rosen KM, Dikkes P. Cippolone H, Villa-Komaroff L. Insulin-like growth factor II in the develop-ing murine cerebellum. Ann NY Acad Sci 692: 277–280, 1993.
  • Murphy M, Drago J, Bartlett PF. Fibroblast growth factor stimulates the proliferation and differentiation of neural precursor cells in vitro. J Neurosci Res 25: 463–475, 1990.
  • Murphy RA, Acheson A, Hodges R, Haskins J, Richards C, Reklow E, Chlumecky V, Barker PA, Alderson RF, Lind-say RM. Immunological relationships of NGF, BDNF, and NT-3: recognition and functional inhibition by antibodies to NGF. J Neurosci 13 (7): 2853–2862, 1993.
  • Murray-Rust J, McDonald NQ, Blundell TL, Hosang M, Oefner C, Winkler F, Bradshaw RA. Topological similar-ities in TGF(32, PDGF-BB and NGF define a superfamily of polypeptide growth factors. Structure 1 (2): 153–159, 1993.
  • Narumi S, Fujita T. Stimulatory effects of substance P and nerve growth factor on neurite outgrowth in embryonic chick dorsal root ganglia. Neuropharmacology 17: 73–76, 1978.
  • Neff NT, Prevette D, Houenou LJ, Lewis ME, Glicksman MA, Yin QW, Oppenheim RW. Insulin-like growth fac-tors: putative muscle-derived trophic agents that promote motoneuron survival. J Neurobiology 24(12): 1578–1588, 1993.
  • Ni L, Jonakait GM. Development of substance P-containing neurons in the central nervous system in mice: an immunocytochemical study. J Comp Neurol 275: 493–510, 1988.
  • Nohno T, Noji S, Koyama E, Myokai F, Ohuchi H, Nishikawa K, Sumitomo S, Taniguchi S, Saito T. Expression patterns of the activin receptor IIA and IIB genes during chick limb development. Frog Clin Biol Res 383B: 705–714, 1993.
  • O'Leary DDM, Daston MM. Neurotrophin-3 has a chemotropic effect on cortical neurons. Soc Neurosci Abstr 20: 688.14, 1994.
  • Oakley RH, Garner AS, Large TH, Frank E. Neurotrophin-3 deprivation selectively eliminates sensory neurons that supply muscle spindles. Soc Neurosci Abstr 20: 358.11, 1994.
  • Ohuchi H, Noji S, Koyama E, Myokai F, Nishikawa K, Nohno T, Tashiro K, Shiokawa K, Matsuo N, Taniguchi S. Expression pattern of the activin receptor type IIA gene during differentiation of chick neural tissues, muscle and skin. FEBS letters 303 (2-3): 185–189, 1992.
  • Oppenheim RW, Houenou LJ, Johnson JE, Lin LFH, Li L, Lo AC, Newsome AL, Prevette DM, Wang S. Developing motor neurons rescued from programmed and axotomy-induced cell death by GDNF. Nature 373: 344–346, 1995.
  • Oppenheim RW, Prevette D, Haverkamp LJ, Houenou L, Yin QW, McManaman J. Biological studies of a putative avian
  • muscle-derived neurotrophic factor that prevents naturally occuring motoneuron death in vivo. J Neurobiology 24: 1065–1079, 1993.
  • Oppenheim RW, Prevette D, Houenou L, Rohrer H, Zacken-fels K, Caroni P, Zapf J. The role of insulin-like growth factors in the differentiation and survival of developing avian motoneurons in vivo. Soc Neurosci Abstr 193.1, 1994.
  • Oppenheim RW, Prevette D, Qin-Wei Y, Collins F, MacDon-ald J. Control of embryonic motoneuron survival in vivo by ciliary neurotrohic factor. Science 251: 1616–1618, 1991.
  • Oppenheim RW, Qin-Wei Y, Prevette D, Yan Q. Brain derived neurotrophic factor rescues avian motoneurons from cell death. Nature 360: 755–757, 1992.
  • Othberg A, Odin P, Ballagi AE, Ahgren A, Funa K, Lindvall 0. Special effects of platelet-derived growth factor on fetal rat and human dopaminergic neurons in vitro. Exp Brain Res 105: 111–122, 1995.
  • Often U, Gadient RA. Neurotrophins and cytokines, interme-diates between the immune and nervous system. Int J Devl Neurosci 13: 147–151, 1995.
  • Often U, Scully JL, Ehrhard PB, Gadient RA. Neurotrophins: signals between the nervous and immune systems. Frog Brain Res 103: 293–305, 1994.
  • Ou P, Elliott RC, Friedman WJ, Wu H, Black IB, Dreyfus CF. Expression and regulation of neurotrophins in basal fore-brain oligodendrocytes. Soc Neurosci Abstr 20: 294.8, 1994.
  • Panni MK, Atkinson J, Lund RD. Evidence for a tropic action of BDNF in guiding axons from transplanted embryonic retinae. Brain Res Dev Brain Res 81: 325–327, 1994.
  • Patterson PH, Fann MJ. Further studies of the distribution of CDF/LIF mRNA. Ciba Found Symp 167, 1992.
  • Pauls TL, Cox JA, Berchtoldt MW. The Ca2+-binding pro-teins parvalbumin and oncomodulin and their genes: new structural and functional findings. Biochim Biophys Acta 1306: 39–54, 1996.
  • Pelton RW, Saxena B, Jones M, Moses HL, Gold LI. Immunohistochemical localization of TGF 31, TGF(32 and TGF (33 in the mouse embryo: expression patterns suggest multiple roles during embryonic development. J Cell Bio1115 (4): 1091–1105, 1991.
  • Pennica D, Arce V, Swanson TA, Vejsada R, Pollock RA, Armani M, Dudley K, Phillips HS, Rosenthal A, Kato AC, Henderson CE. Cardiotrophin-1, a cytokine present in embryonic muscle, supports long-term survival of spinal motoneurons. Neuron 17: 63–74, 1996.
  • Pennica D, Shaw KJ, Swanson TA, Moore MW, Shelton DL, Zionchek KA, Rosenthal A, Taga T, Paoni NF, Wood WI. Cardiotrophin-1. Biological activities and binding to the leukemia inhibitory factor/gp130 signalling complex. J Biol Chem 270 (18): 10915–10922, 1995.
  • Perkins L, Cain LD. Basic fibroblast growth factor (bFGF) increases the survival of embryonic and postnatal basal forebrain cholinergic neurons in primary culture. Int J Dev Neurosci 13: 51–61, 1995.
  • Pinco 0, Carmeli C, Rosenthal A, Kalcheim C. Neu-rotrophin-3 affects proliferation and differentiation of dis-tinct neural crest cells and is present in the early neuraltube of avian embryos. J Neurobiol 24(12): 1626–1641, 1993.
  • Poulsen KT, Armanini MP, Klein RD, Hynes MA, Phillips HS, Rosenthal A. TGF (32 and TGF (33 are potent survival factors for midbrain dopaminergic neurons. Neuron 13: 1245–1252, 1994.
  • Piischel AW, Adams RH, Betz H. Murine semaphorin D/Col-lapsin is a member of a diverse gene family and creates domains inhibitory for axonal extension. Neuron 14: 941–948, 1995.
  • Rabacchi SA, Meyer SL, Baird DH, Springer JE. The neu-rotrophic actions of BDNF in the developing pontine-cerebellar system. Soc Neurosci Abstr 21: 421.11, 1995.
  • Ralphs JR, Wylie L, Hill DJ. Distribution of insulin-like growth factor peptides in the developing chicken embryo. Development 109: 51–58, 1990.
  • Ramon y Cajal S. La rétine des vertébres. La Cellule 9: 119–158, 1892. English translation 1972: The structure of the retina (Thorpe SA, Glickstein M, Thomas CC).
  • Ramon y Cajal, S. Degeneration and regeneration of the ner-vous system. 1913.Translated into english 1928 by R. May.
  • Recio-Pinto E, Rechler MM, Ishii DN. Effects of insulin, insulin-like growth factor-II, and nerve growth factor on neurite formation and survival in cultured sympathetic and sensory neurons. J Neurosci 6: 1211–1219, 1986.
  • Reeves RH, Yao J, Crowley MR, Buck S, Zhang X, Yarowsky P, Gearheart JD, Hilt DC. Astrocytosis and axonal prolif-eration in the hippocampus of S10013 transgenic mice. Proc Natl Acad Sci USA 91: 5359–5363, 1994.
  • Reynolds BA, Tetzlaff W, Weiss S. A multipotent EGF-respon-sive striatal embryonic progenitor cell produces neurons and astrocytes. J Neurosci 12 (11): 4565–4574, 1992.
  • Ringheim GE, Tseng HY, Burgher K, Yamdagni P, Aschmies S, Cai J. Interleukin-1(3 and tumor necrosis factor a regu-late interleukin-6 production from neurons. Soc Neurosci Abstr 20: 130.10, 1994.
  • Rivas RJ, Burmeister DW, Goldberg DJ. Rapid effects of laminin on the growth cone. Neuron 8: 107–115, 1992.
  • Roberts VJ, Barth SL. Expression of messenger ribonucleic acids encoding the inhibin/activin system during mid- and late-gestation rat embryogenesis. Endocrinology 134 (2): 914–923, 1994.
  • Rodrigez-Tébar A, Dechant G, Gotz R, Barde YA. Binding of neurotrophin-3 to its neuronal receptors and interactins with nerve growth factor and brain-derived neurotrophic factor. EMBO J 11: 917–922, 1992.
  • Rodriguez-Tébar A, Dechant G, Barde YA. Binding of brain-derived neurotrophic factor to nerve growth factor recep-tors. Neuron 4:487–492, 1990.
  • Romero AA, Stull NS, Incovetti L. Basic fibroblast growth factor supports the survival of 'purified' rat dopamine neurons in culture. Soc Neurosci abstr 20: 285.1, 1994.
  • Rotwein P, Burgess SK, Milbrandt JD, Krause JE. Differen-tial expression of insulin-like growth factor genes in the rat central nervous system. Proc Natl Acad Sci USA 85: 265–269, 1988.
  • Sample S, Black IB, Dreyfus CF. NT-3 increases neurite length of basal forebrain cholinergic neurons in neuron-glial culture. Soc Neurosci Abstr 20: 289.14, 1994.
  • Sara VR, Carlsson-Skwirut C. Insulin-like growth factors in the nervous system: biosynthesis and biological role. In: Growth factors from genes to clinical application. VR Sara, K Hall & H Low, editors.: 179–191 Raven Press, NY 1990.
  • Sasahara M, Fries JVV, Raines EW, Gown AM, Westrum LE, Frosch MP, Bonthorn DT, Ross R, Collins T. PDGF B-chain in neurons of the central nervous system, posterior pituitary, and in a transgenic model. Cell 64: 217–227, 1991.
  • Scarisbrick LA, Isackson PJ, Jones EG. Developmental expression of neurotrophins in the spinal cord and limb buds of the rat embryo. Soc Neurosci Abstr 20: 539.2, 1994.
  • Schaar DG, Sieber BA, Dreyfus CF, Black M. Regional and cell-specific expression of GDNF in rat brain. Exp neurol 124: 368–371, 1993.
  • Schechterson LC, Bothwell M. Novel roles for neurotrophins are suggested by BDNF and NT-3 expression in develop-ing neurons. Neuron 9: 449–463, 1992.
  • Schluessner HJ, Meyerman R. Expression of BMP-6, a TGF (3 related morphogenetic cytokine, in rat radial glial cells. Glia 12 (2): 161–164, 1994.
  • Schnell L, Schneider R, Kolbeck R, Barde YA, Schwab ME. Neurotrophin-3 enhances sprouting of the corticospinal tract during development and after adult spinal cord lesion. Nature 367: 170–173, 1994.
  • Schwartz JP. Stimulation of nerve growth factor mRNA con-tent in C6 glioma cells by a P-adrenergic receptor and by cyclic AMP. Glia 1: 282–285, 1988.
  • Schwartz M, Solomon A, Lavie V, Ben-Bassat S, Belkin M, Cohen A. Tumor necrosis factor facilitates regeneration of injured central nervous system axons. Brain Res 545: 334–338, 1991.
  • Schwartz PM, Borghesani PR, Levy RL, Pomeroy SL, Segal RA. Abnormal cerebellar development and foliation in BDNF -/-mice reveals a role for neurotrophins in CNS patterning. Neuron 19: 269–281, 1997.
  • Scripter JL, Ide CF. Interleukin-113 expression during development of the mouse brain. Soc Neurosci Abstr 20: 690.7, 1994.
  • Sebire G, Emilie D, Wallon C, Hery C, Devergne 0, Del-fraissy JF, Galanaud P, Tardieu M In vitro production of IL-6, Il- 1 beta and tumor necrosis factor alpha by human embryonic microglia and neural cells. J Immunol 150: 1517–1523, 1993.
  • Segal RA, Takahashi H, McKay RDG. Changes in neu-rotrophin responsiveness during the development of cere-bellar granule neurons. Neuron 9: 1041–1052, 1992.
  • Selinfreund RH, Barger SW, Welsh MJ, Van Eldik U. Anti-sense inhibition of glial S100(3 production results in alter-ations in cell morphology, cytoskeletal organization, and cell proliferation. J Cell Biol 111: 2021-2028, 1990.
  • Sendtner M, Kreutzberg GW, Thoenen H. Ciliary neu-rotrophic factor prevents the degeneration of motor neu-rons after axotomy. Nature 345: 440–444, 1990.
  • Serafini T, Colamarino SA, Leonardo ED, Wang H, Bed-dington R, Skarnes WC, Tessier-Lavigne M. Netrin-1 is required for commissural axon guidance in the develop-ing vertebrate nervous system. Cell 87: 1001–1014, 1996.
  • Serafini T, Kennedy TE, Galko MJ, Mirzayan C, Jessell TM, Tessier-Lavigne M. The netrins define a family of axon outgrowth promoting proteins homologous to C. elegans UNC-6. Cell 78: 409–424, 1994.
  • Shelton DL, Reichardt LF. Studies on the expression of the 13 nerve growth factor gene in the central nervous system: level and regional distribution of NGF mRNA suggest that NGF functions as a trophic factor for several distinct populations of neurons. Proc Natl Acad Sci USA 83: 2714–2718,1985.
  • Shi RY, Borgens RB. Three-dimensional gradients of voltage during development of the nervous system as invisible coordinates for the establishment of embryonic pattern. Develop Dynam 202: 101–114,1995.
  • Shimojo M, Imai Y, Nakajima K, Mizushima S, Uemura A, Kohsaka S. Interleukin-2 enhances the viability of pri-mary cultured rat neocortical neurons. Neurosci Letters 151: 170–173, 1993.
  • Silver J, Sidman RU. A mechanism for the guidance and topographic patterning of retinal ganglion cell axons. J Comp Neurol 243: 547–560, 1984.
  • Singer M, Nordlander RH, Egar M. Axonal guidance during embryogenesis and regeneration in the spinal cord of the newt: the blueprint hypothesis of neuronal pathway pat-terning. J Comp Neurol 185: 1–21,1979.
  • Sklair-Tavron L, Nestler EJ.Opposing effects of morphine and the neurotrophins, NT-3, NT-4 and BNDF, on development of locus coeruleus neurons in vitro. Brain Res 702: 117–125, 1995.
  • Smeyne RJ, Klein R, Schnapp A, Long UK, Bryant S, Lewin A, Lira SA, Barbacid M. Severe sensory and sympathetic neuropathies in mice carrying disrupted Trk/NGF recep-tor gene. Nature 368: 246–249, 1994.
  • Smith M, Clemens J, Kerchner GA, Mendelsohn LG. The insulin-like growth factor-II receptor of rat brain: regional distribution visualized by autoradiography. Brain Res 443: 241–246, 1988.
  • Snider WD. Functions of the neurotrophins during central nervous system development: what the knockouts are teaching us. Cell 77: 627–638, 1994.
  • Sobreviela T, Clary DO, Reichardt LF, Brandabur MM, Kor-dower JH, Mufson EJ. Trk A immunoreactive profiles in the rat central nervous system: colocalization with neu-rons containing p75 nerve growth factor receptor, choline acetyltransferase, and serotonin. J Comp Neurol 350: 587–611, 1994.
  • Soppet D, Escandon E, Maragos J, Middlemas DS, Reid SW, Blair J, Burton LE, Stanton BR, Kaplan DR, Hunter T, Nikolics K, Parada LF. The neurotrophic factors brain-derived neurotrophic factor and neurotrophin-3 are hg-ands for the trkB tyrosine kinase receptor. Cell 65: 895–903, 1991.
  • Springer JE, Seeburger JL, He J, Gabrea A, Blankenhorn EP, Bergman LW. cDNA sequence and differential mRNA regulation of two forms of glial cell line-derived neu-rotrophic factor in Schwann cells and rat skeletal muscle. Exp Neurol 131 (1): 47–52, 1995.
  • Steiner P, Pfeilschifte J, Boeckh C, Radeke H, Otten U. Inter-leukin-1 and tumor necrosis factor a synergistically stim-ulate nerve growth factor synthesis in rat mesangial cells. Am J Physiol 261: F792-798, 1991.
  • Stöckli KA, Lillien LE, Näher-Noe M, Breitfield G, Hughes RA, Raff MC, Thoenen H, Sendtner M. Regional distrib-ution, developmental changes, and cellular localization of CNTF-mRNA and protein in the rat brain. J Cell Biol 115 (2): 447–459, 1991.
  • Stöckli KA, Lottspeich F, Sendtner M, Masiakowski P, Car-roll P, Gotz R, Lindholm D, Thoenen H. Molecular cloning, expression and regional distribution of rat cil-iary neurotrophic factor. Nature 342 (6252): 920–923, 1989.
  • Stromberg I, Björklund L, Johansson M, Tomac A, Collins F, Olson L, Hoffer B, Humpel C. Glial cell line-derived neu-rotrophic factor is expressed in the developing but not adult striatum and stimulates developing dopamine neu-rons in vivo. Exp neurol 124: 401–412, 1993.
  • Suzuki K, Koike T. BDNF suppresses programmed death of cerebellar granule cells through a posttranslational mech-anism. Mol Chem Neuropath30: 101–124, 1997.
  • Tabira T, Konishi Y, Gallyas F. Neurotrophic effect of hematopoietic cytokines on cholinergic and other neurons in vitro. Int J Dev Neurosci 13: 241–252, 1995.
  • Takahashi R, Yokoji H, Misawa H, Hayashi M, Hu J, Deguchi T. A null mutation in the human CNTF gene is not causally related to neurological disease. Nature Genet 7: 79–84, 1994.
  • Tam SY, Tsai M, Yamaguchi M, Yano K, Butterfield Ill, Galli SJ. Expression of functional trkA receptor tyrosine kinase in the HMC-1 human mast cell line and in human mast-cells. Blood 90: 1807–1820, 1997.
  • Tamada A, Shirasaki R, Murakami F. Floor plate chemoat-tracts crossed axons and chemorepels uncrossed axons in the vertebrate brain. Neuron 14: 1083–1093, 1995.
  • Taniguchi M, Yuasa S, Fujisawa H, Naruse I, Saga S, Mishina M, Yagi T. Disruption of semaphorin III/D gene causes severe abnormality in peripheral nerve projection. Neuron 19: 519–530, 1997.
  • Tessarolo L, Tsoulfas P, Martin-Zanca D, Gilbert DJ, Jenkins NA, Copeland NG, Parada LF. trkC, a receptor for neu-rotrophin-3, is widely expressed in the developing nervous system and in nonneural tissues. Development 118: 463–475, 1993.
  • Tessier-Lavigne M, Placzek M. Target attraction: are devel-oping axons guided by chemotropism? Trends Neurosci 14 (7): 303–310, 1991.
  • Thoenen H. The changing scene of neurotrophic factors. Trends Neurosci 14(5): 165–170, 1991.
  • Timmusk T, Belluardo N, Metsis M, Persson H. Widespread and developmentally regulated expression of neu-rotrophin-4 mRNA in rat brain and peripheral tissues. Eur J Neurosci 5 (6): 605–613, 1993.
  • Tsoulfas P, Soppet D, Escandon E, Tessarollo L, Mandoza-Ramirez JL, Rosenthal A, Nikolics K, Parada LF. The rat TrkC locus encodes multiple neurogenic receptors that exhibit differential response to NT-3 in PC12 cells. Neu-ron 10: 975–990, 1993.
  • Tuuri T, Eramaa M, Hilden K, Ritvos 0. The tissue distribu-tion of activin PA and 13B subunit and follistatin messen-ger ribonucleic acids suggests multiple sites of action for the activin-follistatin system during human development. J Clin Endocrinol Metab 78(6): 1521–1524, 1994.
  • Tweardy DJ, Glazer EW, Mott PL, Anderson K. Modulation by tumor necrosis factor et of human astroglial cell pro-duction of granulocyte-macrophage colony stimulating factor and granulocyte colony stimulating factor. J Neu-roimmunol 32 (3): 269–278, 1991.
  • Ueda S, Hou XP, Whitaker-Azmitia PM, Azmitia EC. Neuro-glial neurotrophic interaction in the S10013 retarded mutant mouse (Polydactyly Nagoya). Brain Res 633: 284–288, 1994.
  • Unsicker K, Engels S, Hamm C, Liidecke G, Meier C, Renz-ing J, Terbrack HG, Flanders K. Molecular control of neural platicity by the multifunctional growth factor fam-ilies of the FGFs and the TGF (3s. Ann Anat 174: 405–407, 1992.
  • Unsicker K, Meier C, Flanders KC. Expression and function of TGF132 and 133 in the embryonic chick spinal cord, hindbrain, and spinal ganglia. Soc Neurosci Abstr 20: 452.14, 1994.
  • Vantini G. The pharmacological potential of neurotrophins: a perspective. Psychoneuroendocrinology 17(4): 401–410, 1992.
  • Vantini G, Schiavo N, Di Martino A, Polato P, Triban C, Cal-legaro L, Toffano G, Leon A. Evidence for a physiologi-cal role of nerve growth factor in the central nervous system of neonatal rats. Neuron 3: 267–273, 1989.
  • Varela-Echavarria A, Tucker A, Puschel AW, Guthrie S. Motor axon subpopulations respond differentially to the chemorepellents netrin-1 and semaphorin D. Neuron 18: 193–207, 1997.
  • Vazquez ME, Ebendal T. Messenger RNAs for trk and the low affinity NGF receptor in the rat basal forebrain. Neu-roreport 2: 593–596, 1991.
  • Verdi JM, Anderson DJ. Neurotrophins regulate sequential changes in neurotrophin receptor expression. Neuron 13: 1359–1372, 1994.
  • Vescovi AL, Gritti A, Cova L, Parati EA. LIE supports the differentiation of pluripotential stem cells of the human embryonic CNS in vitro. Soc Neurosci Abstr 20: 21.5, 1994.
  • von Bartheld CS, Schober A, Kinoshita Y, Williams R, Eben-dal T, Bothwell M. Noradrenergic neurons in the locus coeruleus of birds express trkA, transport NGF and respond to NGF. J Neurosci 15: 2225–2239, 1995.
  • Walicke PA. Basic and acidic fibroblast growth factors have trophic effects on neurons from multiple CNS regions. J Neurosci 8 (7): 2618–2627, 1988.
  • Wanaka A, Milbrandt J, Johnson EM jr. Expression of FGF receptor gene in rat development. Development 111 (2): 455–468, 1991.
  • Wang FZ, Yao H, Ding AS. Effects of interleukin-1 and inter-leukin-2 on rat hippocampal neurons in culture. Soc Neu-rosci Abstr 20: 690.8, 1994.
  • Ware CB, Horowitz MC, Renshaw BR, Hunt JS, Liggitt D, Koblar SA, Gliniak BC, McKenna HJ, Papayannopoulou T, thoma B, Cheng L, Donovan PJ, Peschon JJ, Bartlett PF, Willis CR, Wright BD, Carpenter MK, Davidson BL, Gearing DP. Targeted disruption of the low affinity leukemia inhibitory factor receptor gene causes placental, skeletal, neural and metabolic defects and results in pen-natal death. Development 121: 1283–1299, 1995.
  • Wayne DB, Heaton MB. The response of cultured trigeminal and spinal cord motoneurons to nerve growth factor. Dev Bio1138: 473–483, 1990.
  • Weis J, Kriittgen A, Simon R, Thier M, Schroder JM, Hein-rich PC, Rose-John S. Functional analysis of recombinant human CNTF mutants: relationship to interleukin-6. Soc Neurosci Abstr 20: 288.17, 1994.
  • Weiss P In vitro experiments on the factors determining the course of the outgrowing nerve fiber. J Exp Zool 68: 393–448, 1934.
  • Weiss PA. Neurobiology in statu nascendi. Frog Brain Res 45: 7–38, 1976.
  • Wetmore C, Bygdeman M, Olson L. High and low affinity NGF receptor mRNAs in human fetal spinal cord and gan-glia. Neuroreport 3: 689–692, 1992.
  • Wetmore C, Ernfors P, Persson H, Olson L. Localization of brain-derived neurotrophic factor mRNA to neurons in the brain by in situ hybridization. Exp Neurol 109: 141–152, 1990.
  • Whittemore SR, Ebendal T, Larkfors L, Olson L, Seiger A, Stromberg I, Persson H. Developmental and regional expression of 13 nerve growth factor messenger RNA and protein in the rat central nervous system. Proc Natl Acad Sci USA 83: 817–821, 1986.
  • Widmer HR, Hefti F. Neurotrophin-4/5 promotes survival and differentiation of rat striatal neurons developing in culture. Eur J Neurosci 6(11): 1669–1679, 1994a.
  • Widmer HR, Hefti F. Stimulation of GABAergic neuron dif-ferentiation by NT-4/5 in cultures of rat cerebral cortex. Brain Res Dev Brain Res 80: 279–284, 1994b.
  • Williams R, Grapin A, Backstrom A, LeDouarin N, Ebendal T. Neurotrophin high affinity Trk receptor mRNA expres-sion within the trigeminal ganglion under normal and experimental conditions. Soc Neurosci Abstr 20: 109.4, 1994.
  • Wong V. Arriaga R, Ip NY, Lindsay RM. The neurotrophins BDNF, NT-3 and NT-415, but not NGF, up-regulate the cholinergic phenotype of developing motor neurons. Eur J Neurosci 5: 466–474, 1993.
  • Wright PW, Scherer SE, Gallo V. PDGF and bFGF regulate glutamate receptor expression in developing glia. Soc Neurosci Abstr 20: 214.11, 1994.
  • Yabuuchi K, Minami M, Katsumata S, Satoh M. Localization of type 1 interleukin-1 receptor mRNA in the rat brain. Brain Res Mol Brain Res 27: 27–36, 1994.
  • Yamamoto H, Gurney ME. Human platelets contain brain-derived neurotrophic factor. J Neurosci 10: 3469–3478, 1990.
  • Yan Q, Matheson C, Lopez OT. In vivo neurotrophic effects of GDNF on neonatal and adult facial motor neurons. Nature 373 (6512): 341–344, 1995.
  • Yan Q, Snider WD, Pinzone JJ, Johnson EM. Retrograde transport of nerve growth factor in motoneurons of devel-oping rats: assessment of potential neurotrophic effects. Neuron 1: 335–343, 1988.
  • Yao J, Hill DC, Reeves RH. Neurite elongation of embryonic chick cortical neurons enhanced by medium conditioned from astrocytes of S10013 transgenic mice. Soc Neurosci Abstr 20: 289.13, 1994.
  • Yeh HJ, Silos-Santiago I, Wang YX, george RJ, Snider WD, Deuel TF. Developmental expression of the platelet-derived growth factor a-receptor gene in mammalian cen-tral nervous system. Proc Natl Acad Sci USA 90: 1952–1956, 1993.
  • Yeo TT, Chua-Couzens J, Butcher LL, Bredesen DE, Cooper JD, Valletta JS, Mobley WC, Longo FM. Absence of p75NTR causes increased basal forebrain cholinergic neu-ron size, choline acetyltransferase activity and target innervation. J Neurosci 17: 7594–7605, 1997.
  • Yokoyama M, Morrison RS, Black [B, Dreyfus CF. Septal neuron cholinergic and GAI3Aergic functions: differential regulation by basic fibroblast growth factor and epidermal growth factor. Dev Brain Res 78: 201–209, 1994.
  • Zang Z, Mehler MF, Marmur R, Wozney JM, Kessler JA. Bone Morphogenetic Proteins are expressed in develop-ing mouse brain and are neurotrophic in vitro. Soc Neu-rosci Abstr 20: 537.16, 1994.
  • Zawada WM, Bell P, Freed CR. Combination of IGF-I and bFGF improves survival of rat mesencephalic dopamine neurons in vitro. Soc Neurosci Abstr 20: 79.12, 1994.
  • Zhou L, Wright DE, Snider WD. Cloning of a semaphorin member related to mouse semaphorin III: comparison of mRNA expression patterns in the spinal cord and the periphery. Soc Neurosci Abstr 20: 124.1, 1995.
  • Zhou XF, Rush RA. Localization of neurotrophin-3-like immunoreactivity in the rat central nervous system. Brain Res 643: 162–172, 1994.
  • Zurn A. Fibroblast growth factor differentially modulates the neurotransmitter phenotype of cultured sympathetic neu-rons. J Neurosci 12(11): 4195–4201, 1992.
  • Zurn AD, Werren F. Development of CNS cholinergic neu-rons in vitro: selective effects of CNTF and LIF on neu-rons from mesencephalic cranial motor nuclei. Dev Biol 163 (2): 309–315, 1994.
  • Zurn AD, Baetge EE, Hammang JP, Tan SA, Aebischer P. GDNF: a new neurotrophic factor for motoneurons. Neuroreport 6: 113–118, 1994.

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