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Research Article

Optic neuritis in multiple sclerosis

Pages 161-186 | Published online: 08 Jul 2009

References

  • Kinnunen E. The incidence of optic neuritis and its prognosis for multiple sclerosis. Acta Neurol Scand. 1983;68:371–377.
  • Rodriguez M, Siva A, Cross SA, O'Brien PC, Kurland Li Optic neuritis: a population-based study in Olmsted County, Minnesota [see comments]. Neurology. 1995;45: 244–250.
  • Cantore WA. Optic neuritis. Pa Med. 1996;99(Suppl):96–98.
  • Optic Neuritis Study Group. The clinical profile of optic neuritis. Experience of the Optic Neuritis Treatment Trial [see comments]. Arch Ophthalmol. 1991;109:1673–1678.
  • Beck RW. Optic neuritis. In: Miller NR, Newman NJ, editors. The essentials: Walsh & Hoyt's clinical neuro-ophthalmology. Baltimore: Williams & Wilkins, 1999; 599–648.
  • Keltner JL, Johnson CA, Spurr JO, Beck RW. Baseline visual field profile of optic neuritis. The experience of the optic neuritis treatment trial. Optic Neuritis Study Group [see comments]. Arch Ophthalmol. '993;1'1:231–234.
  • Keltner JL, Johnson CA, Spurr JO, Beck RW. Visual field profile of optic neuritis. One-year follow-up in the Optic Neuritis Treatment Trial. Arch Ophthalmol. 1994;112: 946–953.
  • Menage MJ, Papakostopoulos D, Dean Hart JC, Papakostopoulos S, Gogolitsyn Y. The Farnsworth-Munsell ioo-hue test in the first episode of demyelinating optic neuritis [see comments]. Br J Ophthalmol. 1993;77:68–74.
  • Engell T, Trojaborg W, Raun NE. Subclinical optic neuropathy in multiple sclerosis. A neuro-ophthalmological investigation by means of visually evoked response, Farnsworth-Munsell loo-hue test and Ishihara test and their diagnostic value. Acta Ophthalmol (Copenh). 1987;65:735–740.
  • Nichols BE, Thompson HS, Stone EM. Evaluation of a significantly shorter version of the Farnsworth-Munsell loo-hue test in patients with three different optic neuropathies. J Neuroophthalmol. 1997;17:1-6.
  • Frederiksen JL, Olesen J, Larsson HB, Petrera J, Sellebj erg FT. Acute unilateral papillitis versus retrobulbar neuritis: relation to multiple sclerosis. Multiple Sclerosis. 1996;1: 223–227.
  • Frisen L, Hoyt WE Insidious atrophy of retinal nerve fibers in multiple sclerosis. Funduscopic identification in patients with and without visual complaints. Arch Ophthalmol. 1974;92:91–97.
  • Spa1ton DJ, Hitchings RA, Hunter PA, editors. Atlas of clinical ophthalmology. London: Wolfe Publishing, 1994; 17.18.
  • Lightman S, McDonald WI, Bird AC, Francis DA, Hoskins A, Batchelor JR. Retinal venous sheathing in optic neuritis. Its significance for the pathogenesis of multiple sclerosis. Brain. 1987;I10\(pt 2):405–414.
  • Killer HE, Job 0. Differential diagnostic considerations on retrobulbar neuritis. Nervenarzt. 1996;67: 815–820.
  • Swartz NG, Beck RW, Savino PJ, Sergott RC, Bosley TM, Lam BL. Pain in anterior ischemic optic neuropathy. J Neuroophthalmol. 1995;15:9-10.
  • Warner JE, Lessell S, Rizzo in JF, Newman NJ. Does optic disc appearance distinguish ischemic optic neuropathy from optic neuritis? Arch Ophthalmol. 1997;115:14.08-141o.
  • Smith JL, Hoyt WF, Susac JO. Ocular fundus in acute Leber optic neuropathy. Arch Ophthalmol. 1973;90:349–354.
  • Brown MD, Torroni A, Reckord CL, et al. Phylogenetic analysis of Caucasian I 1778-positive and 11778-negative Leber's hereditary optic neuropathy patients indicates multiple independent occurrences of the common primary mitochondrial DNA mutations. Hum Mutat. 1995;6.
  • Selbst RG, Selhorst JB, Harbison JW, et al. Parainfectious optic neuritis: report and review following varicella. Arch Neurol. 1983;40:347–350.
  • Manor RS, Cohen S, Ben-Sira T. Bilateral acute retrobulbar optic neuropathy associated with epidemic keratoconjunctivitis in a compromised host. Arch Ophthalmol. 1986;104:1271–1272.
  • Spalton DJ, Murdoch I, Holder GE. Coxsackie B5 papillitis. J Neurol Neurosurg Psychiatry. 1989;52: 1310–1311.
  • McKibbin M, Cleland PG, Morgan SI Bilateral optic neuritis after hepatitis A. J Neurol Neurosurg Psychiatry. I995;58(4):508.
  • Achiron LR. Postinfectious hepatitis B optic neuritis. Optom Vis Sci. 1994;71:53–56.
  • Gross JG, Sadun AA, Wiley CA, et al. Severe visual loss related to isolated peripapillary retinal and optic nerve head cytomegalovirus infection. Am J Ophthalmol. 1989; 108:691–698.
  • Jones J, Gardner W, Newman T. Severe optic neuritis in infectious mononucleosis. Ann Emerg Med. 1988;17:361–364.
  • Sweeney BJ, Manji H, Gilson RJC, et al. Optic neuritis and HIV-, infection. J Neurol Neurosurg Psychiatry. 1993;56:705–707.
  • Srivastava SP, Neman HV. Optic neuritis in measles. Br J Ophthalmol. 1963;47:180–181.
  • Strong LE, Henderson JW, Gangitano JL. Bilateral retrobulbar neuritis secondary to mumps. Am J Ophthalmol. 1974;78:331–332.
  • Connolly JH, Hutchinson WM, Allen IV, et al. Carotid artery thrombosis, encephalitis, myelitis and optic neuritis associated with rubella virus infections. Brain. 1975; 98:583–594.
  • Purvin V, Hrisomalos N, Dunn D. Varicella optic neuritis. Neurology. 1988;38:501–503.
  • Deane JS, Bibby K. Bilateral optic neuritis following herpes zoster ophthalmicus. Arch Ophthalmol. 1995;113:972–973.
  • Colarizi A, Panico E. Atrofia secondaria del nervo ottico consecutiva a infezione carbonchiosa. Bull Acad Med Roma. 1933;59:399–408.
  • Smallberg GJ, Sherman SH, Pezeshkpour GH, et al. Optic neuropathy due to brain abscess. Am J Ophthalmol. 1976;82:188–192.
  • McLean DR, Russell N, Khan MY. Neurobrucellosis: clinical and therapeutic features. Clin Infect Dis. 1992;15:582–590.
  • Brazis PW, Stokes HR, Ervin FR. Optic neuritis in cat scratch disease. J Clin Neuro-ophthalmol. 1986;6: 172–174.
  • Ellsworth J, Marks, MI, Vose A. Meningococcal meningitis in children. Can Med Assoc J.1979; 120(2):155–158.
  • Miller HG, Staton JB, Gibbons JL. Parainfectious encephalomyelitis and related syndromes: a critical review of the neurological complications of certain specific fevers. Q J Med. 1956;25:427–505.
  • Miller BW, Frenkel M. Report of a case of tuberculosis retrobulbar neuritis and osteomyelitis. Am J Ophthalmol. 1971;71:751–756.
  • Bajpai PC, Dikshit SK. Bilateral optic neuritis and encephalitis accompanying typhoid. J Indian Med Assoc. 1958;30:54–57.
  • Vital Durand D, Gerard A, Rousset H. Neurological manifestations of Whipple disease. [in French]. Rev Neurol. 2002;158(10CI):988–992.
  • Yen M-Y, Lui J-H. Bilateral optic neuritis following Bacille Calmette-Guerin (BCG) vaccination. J Clin Neuro-ophthalmol. 1991;114:2437–2450.
  • Berkman N, Banzarti T, Dhaoui R, et al. Neuropapillite bilaterale avec decollement sereux du neuroepithelium, au decours d'une vaccination contre l'hepatite B. Bull Soc Ophtalmol Fr. 1996;96:187–190.
  • Chayakul V, Ishikawa S, Chotibut S, et al. Convergence insufficiency and optic neuritis due to anti-rabic inoculation. Jpn J Ophthalmol. 1975;19:307–314.
  • Topaloglu H, Berker M, Kansu T, et al. Optic neuritis and myelitis after booster tetanus toxoid vaccination. Lancet. 1992;339:178–179.
  • Wagener HP. Edema of the optic disks in cases of encephalitis. Am J Med Sci. 1952;223:205–215.
  • Perry HD, Mallen FJ, Grodin RW, et al. Reversible blindness in optic neuritis associated with influenza vaccination. Ann Ophthalmol. 1979; II:545–550.
  • Graham EM, Ellis CJK, Sanders MD, et al. Optic neuropathy in sarcoidosis. J Neurol Neurosurg Psychiatry. 1986;49:756–763.
  • Golnik KC, Newman SA, Wispelway B. Cryptococcal optic neuropathy in the acquired immune deficiency syndrome. J Clin Neuro-ophthalmol. 1991;1i:96–103.
  • Gross JG, Sadun AA, Wiley CA, et al. Severe visual loss related to isolated peripapillary retinal and optic nerve head cytomegalovirus infection. Am J Ophthalmol. 1989; 108:691–698.
  • Grossniklaus HE, Frank KE, Tomsak RL. Cytomegalovirus retinitis and optic neuritis in acquired immune deficiency syndrome: report of a case. Ophthalmology. 1987;94:1601–1604.
  • Litoff D, Catalano RA. Herpes zoster optic neuritis in human immunodeficiency virus infection. Arch Ophthalmol. 1990;108:782–783.
  • Zambrano W, Perez GM, Smith JL. Acute syphilitic blindness in AIDS. J Clin Neuro-ophthalmol. 1987;7: 1–5.
  • Nichols JW, Goodwin JA. Neuro-ophthalmologic complications of AIDS. Semin Ophthalmol. 1992;7: 24–29.
  • Falcone PM, Notis C, Merhige K. Toxoplasmic papillitis as the initial manifestation of acquired immunodeficiency syndrome. Ann Ophthalmol. 1993;25:56–57.
  • Holland GN, Engstrom Jr RE, Glasgow BJ, et al. Ocular toxoplasmosis in patients with the acquired immunodeficiency syndrome. Am J Ophthalmol. 1988; 106:653–657.
  • Larsen M, Toft PB, Bernhard P, Herning M. Bilateral optic neuritis in acute human immunodeficiency virus infection. Acta Ophthalmol Scand. 1998;76(6):737–738.
  • Newman NJ, Lessell S. Bilateral optic neuropathies with remission in two HIV-positive men. J Clin Neuro-ophthalmol. 1992;12(I): 1–5.
  • Jacobson DM, Marx JJ, Dlesk A. Frequency and clinical significance of Lyme seropositivity in patients with isolated optic neuritis. Neurology. 1991;41:706-711 I.
  • Sanborn GE, Kivlin JD, Stevens M. Optic neuritis secondary to sinus disease. Arch Otolaryngol. 1984;110(12):816–819.
  • Gass JDM. Diseases of the optic nerve that may simulate macular disease. Trans Am Acad Ophthalmol Otolaryngol. 1977;83: 766–769.
  • Moreno RJ, Weisman J, Waller S. Neuroretinitis: an unusual presentation of ocular toxoplasmosis. Ann Ophthalmol. 1992;24:68–70.
  • Farthing CF, Howard RS, Thin RN. Papillitis and hepatitis B. Br Med J. 1986;29(2):1712.
  • Knapp A. Optic neuritis after influenza, with changes in the spinal fluid. Arch Ophthalmol. 1916;45: 247–249.
  • Arruga J, Valentines J, Mauri F, et al. Neuroretinitis in acquired syphilis. Ophthalmology. 1985;92: 262–270.
  • Audry-Chaboud D, Durnas R, Audry F, et al. Coxsackie B virus neuropapillitis. Rev Otoneuro-ophthalmol. 1981;53:473–482.
  • Folk JC, Weingeist TA, Corbett JJ, et al. Syphilitic neuroretinitis. Am J Ophthalmol. 1983;95:480.
  • Copeland Jr RA. Lyme uveitis. Int Ophthalmol Clin. 1990;30:291.
  • Barkay S, Garzozi H. Leptospirosis and uveitis. Ann Ophthalmol. 1984; 16:164.
  • Tabbara KF. Brucellosis and nonsyphilitic treponemal uveitis. Int Ophthalmol Clin. 1990;30:294.
  • Jampol LM, Staruch S, Albert DM. Intraocular nocardiosis. Am J Ophthalmol. 1973;76:568.
  • Schlaegel TF, O'Connor GR. Tuberculosis and syphilis. Arch Ophthalmol. 198 I;99:2206.
  • Jay WM, Schanzlin DJ, Fritz KJ. Medical therapy of metastatic meningococcal endophthalmitis. Am J Ophthalmol. 1979;87:567.
  • Murray HW, Knox DL, Green WR, et al. Cytomegalovirus retinitis in adults: a manifestation of disseminated viral infection. Am J Med. 1977;63:574.
  • Pavan-Langston D, Brockhurst RJ. Herpes simplex panuveitis. Arch Ophthalmol. 1969;81:783.
  • Brown RM, Mendis U. Retinal arteritis complicating herpes zoster ophthalmicus. Br J Ophthalmol. 1973;57:344.
  • Krill AE. The retinal disease of rubella. Arch Ophthalmol. 1967;77: 445.
  • Font RL, Jenis EH, Tuck KD. Measles maculopathy associated with subacute sclerosing panencephalitis (SSPE). Arch Pathol. 1973;96:168.
  • Shuman JS, Orellana J, Friedman AH, et al. Acquired immunodeficiency syndrome (AIDS). &ITV Ophthalmol. 1987;31: 384.
  • Gagliuso DJ, Teich SA, Friedman AH, et al. Ocular toxoplasmosis in AIDS patients. Trans Am Ophthalmol Soc. 1990;88:63.
  • Wilkinson CP. Ocular toxocariasis. In: Schachat AP, Murphy RB, Patz A, editors. Retina, VOL 2. St. Louis: CV Mosby, 1989.
  • Bird AC, Anderson J, Fuglsang H. Morphology of posterior segment lesions of the eye in patients with onchocerciasis. Br J Ophthalmol. 1976;60:2.
  • Tabbara KF. Endogenous ocular candidiasis. In: Tabbara KF, Hyndiuk RA, editors. Infections of the eye. Boston: Little, Brown, 1986.
  • Schlaegel TF. Presumed ocular histoplasmosis. In: Tasman W, Jaeger EA, editors. Duane's clinical ophthalmology, Vol. 4. Philadelphia: JB Lippincott, 1981.
  • Shields JA, Wright DM, Augsberger JJ, et al. Cryptococcal chorioretinitis. Am J Ophthalmol. 198o:89:21o.
  • Naidoff MA, Green WR. Endogenous Aspergillus endophthalmitis occurring after kidney transplant. Am J Ophthalmol. 1975;79:502.
  • Zakka KA, Foos RY, Brown WJ. Intraocular coceidioidomycosis. Surv Ophthalmol. 1978;22:313.
  • Bond WI, Sanders CV, Joffe L, et al. Presumed blastomycosis endophthalmitis. Ann Ophthalmol. 1982;14:1183.
  • Bullen CL, Liesegang TJ, McDonald TJ, DeRemee RA. Ocular complications of Wegener's granulomatosis. Ophthalmology. 1983;90:279–290.
  • Haynes BF, Fishman ML, Fauci AS, Wolff SM. The ocular manifestations of Wegener's granulomatosis. Fifteen years experience and review of the literature. Am J Med. 1977;63:131.
  • Baer JC, Raizman MB, Foster CS. Ocular Behcet's disease in the U.S.: clinical presentation and visual outcome in 29 patients. In: Masahiko U, Shigeaki 0, Koki A, editors. Proceedings of the 5th International Symposium on the Immunology and Immunopathology of the Eye, 1990 March 13–15; Tokyo, Japan. New York: Elsevier Science, 1990; 383.
  • Oppenheimer S, Hoffbrand BI. Optic neuritis and myelopathy in SLE. Can J Neurol Sci. 1986;13: 129.
  • Svitra PP, Perry H. Vogt-Koyanagi-Harada (uveomeningitic) syndrome. In: Albert DM, Jakobiec FA, editors. Principles and practice of ophthalmology. Philadelphia: WB Sanders Company, 1994.
  • Kincaid MC, Green WR. Ocular and orbital involvement in leukaemia. Surv Ophthalmol. 1983;27:211–232.
  • Qualman SJ, Mendelsohn G, Mann RB, Green WR. Intraocular lymphomas: natural history based on a clinicopathologic study of eight cases and review of the literature. Cancer. 1983;52:878–886.
  • Font RL, Naumann G, Zimmerman LE. Primary malignant melanoma of the skin metastatic to the eye and orbit. Am J Ophthalmol. 1967; 63:738–754.
  • Stephens RF, Shields JA. Diagnosis and management of cancer metastatic to the uvea: a study of 70 cases. Ophthalmology. 1979;86: 1336�1349.
  • Ryan SJ, Maumenee AE. Birdshot
  • Kirkham TH, Ffytche TJ, Sanders MD. Placoid pigment epitheliopathy Br J Ophthalmol. 1972;56:875.
  • Dodwell DG, Jampol LM, Rosenburg M, et al. Optic nerve
  • Fujisawa C, Fujiara H, Hasegawa E, et al. The cases of serpiginous choroiditis [in Japanese]. Nippon Ganka Gakkai Zasshi. 1978;82:135.
  • McCluskey PJ,Watson PG, Lightman S, Haybittle J, Restori M,Branley M. Posterior scleritis: clinical features, systemic
  • Dutton D, Burde RM, Kiingele TG. Autoimmune retrobulbar optic neuritis. Am J Ophthalmol. 1982;94: II–17.
  • JW IJ, Conti-Kelly AM, Greco P, Abedi M, Amos M, Provenzale JM. Anti-phospholipid antibodies in patients with multiple sclerosis and MS-like illnesses: MS or APS? [see comments]. Lupus. 1999;8:109�115.
  • Sakuma R, Fujihara K, Sato N, Mochizuki H, Itoyama Y. Optic- spinal form of multiple sclerosis and anti-thyroid autoantibodies. J Neurol. 1999;246:449–453.
  • Bennet WM. Bronchial carcinoma presenting with non-metastatic bilateral papillitis. Br Dis Chest. 1986; 80: 189-90.
  • Boghen D, Sebag M, Michaud J. Arch Neurol. 1988;45:353–356.
  • Coppeto JR, Monteiro ML, Cannarozzi DB. Optic neuropathy associated with chronic lymphomatous meningitis. J Clin Neuroophthalmol. 1988;8:39–45.
  • Pillay N, Gilbert D, Ebers GC, Brown JD. Internuclear ophthalmoplegia and 'optic neuritis': paraneoplastic effects of bronchial carcinoma. Neurology. 1984;34:788–791.
  • Perkin GD, Rose FC. Optic neuritis and its differential diagnosis. Oxford medical publications. New York: Oxford University Press, 1979.
  • Engell T, Sellebjerg E, Jensen C. Changes in the retinal veins in acute optic neuritis. Acta Neurol Scand. 1999;100:81–83.
  • Traugott U, Raine CS, McFarlin DE. Acute experimental allergic encephalomyelitis in the mouse: immunopathology of the developing lesion. Cell Immunol. 1985;91:240–254.
  • Prineas JW, Barnard RO, Kwon EE, et al. Multiple sclerosis: remyelination of nascent lesions. Ann Neurol. 1993;33:137–151.
  • Frick E. Optic neuritis and multiple sclerosis. Cell-mediated cytotoxicity by peripheral blood lymphocytes against basic protein of myelin, encephalitogenic peptide, cerebrosides and gangliosides. Eur Neurol. 1988;28:120–125.
  • Sellebj erg E, Christiansen M, Nielsen PM, Frederiksen JL. Cerebrospinal fluid measures of disease activity in patients with multiple sclerosis. Multiple Sclerosis. 1998;4:475–479.
  • Soderstrom M, Link H, Xu Z, Frederiksson S. Optic neuritis and multiple sclerosis: anti-MBP and anti-MBP peptide antibody-secreting cells are accumulated in CSE Neurology. 1993;43:1215–1222.
  • Navikas V, Link H. Review: Cytokines and the pathogenesis of multiple sclerosis. J Neurosci Res. 1996;45:322–333.
  • Shields DC, Tyor WR, Deibler GE, Banik NL. Increased calpain expression in experimental demyelinating optic neuritis: an immunocytochemical study. Brain Res. 1998;784:299–304.
  • Inuzuka T, Sato S, Baba H, Miyatake T. Neutral protease in cerebrospinal fluid from patients with multiple sclerosis and other neurological diseases. Acta Neurol Scand. 1987;76:18–23.
  • Navikas V, He B, Link J, Haglund M, Soderstrom M, Frederikson S. Augmented expression of tumour necrosis factor-alpha and lymphotoxin in mononuclear cells in multiple sclerosis and optic neuritis. Brain. 1996;I I9(pt I): 213–223.
  • Potter NT, Bigazzi PE. Acute optic neuritis associated with immunization with the CNS myelin proteolipid protein. Invest Ophthalmol Vis Sci. 1992;33:1717–1722.
  • Sellebjerg FT, Frederiksen JL, Olsson T. Anti-myelin basic protein and anti-proteolipid protein antibody-secreting cells in the cerebrospinal fluid of patients with acute optic neuritis. Arch Neurol. 1994;51:1032–1036.
  • Warren KG, Catz I, Johnson E, Mielke B. Anti-myelin basic protein and anti-proteolipid protein specific forms of multiple sclerosis. Ann Neurol. 1994;35:280–289.
  • Sellebjerg F, Madsen HO, Frederiksen JL, Ryder LP, Svejgaard A. Acute optic neuritis: myelin basic protein and proteolipid protein antibodies, affinity, and the HLA system. Ann Neurol. 1995;38:943–950.
  • Sadovnik AD, Baird PA, Ward RH. Multiple sclerosis: updated risks for relatives. Am J Med Genet. 1988;29: 533–541.
  • Wilkstrom J, Kinnunen E, Porras J. The age-specific prevalence ratio of familial multiple sclerosis. Neuroepidemiology. 1984;3:74–82.
  • Ebers GC, Bulman DE, Sadovnick AD, et al. A population-based study of multiple sclerosis in twins. N Engl J Med. 1986;315:1638–1642.
  • Kinnunen E, Koskenvuo M, Kaprio J, Aho K. Multiple sclerosis in a nation-wide series of twins. Neurology. 1987;37:1627–1629.
  • Sadovnik AD, Armstrong H, Rice GPA, et al. A population-based study of multiple sclerosis in twins: update. Ann Neurol. 1993;33:281–285.
  • Mumford CJ, Wood NW, Kellar-Wood H, et al. The UK study of multiple sclerosis in twins (Abstract). J Neurol. 1992;239 (Suppl 2):62.
  • Doolittle TH, Myers RH, Lehrich JR, et al. Multiple sclerosis sibling pairs: clustered onset and familial predisposition. Neurology. 1990; 40:1546–1552.
  • Bulman DE, Sadovnik AD, Ebers GC. Age of onset in siblings concordant for multiple sclerosis. Brain. 1991;114:937–950.
  • Haines JL, Terwedow HA, Burgess K, Pericak-Vance MA, Rimmler JB, Martin ER, et al. Linkage of the MHC to familial multiple sclerosis suggests genetic heterogeneity. The Multiple Sclerosis Genetics Group. Hum Mol Genet. 1998;7(8):1229–1234.
  • The Multiple Sclerosis Group, Barcellos LF, Oksenberg JR, Green AJ, Bucher P, Rimmler JB, et al. Genetic basis for clinical expression in multiple sclerosis. Brain. 2002; 125:150–158.
  • Butterfield RJ, Blankenhorn EP, Roper RJ, Zachary SF, Doerge RW, Teuscher C. Identification of genetic loci controlling the characteristics and severity of brain and spinal cord lesions in experimental allergic encephalomyelitis. Am J Pathol. 2000;157:637–645.
  • Sobel RA. Genetic and epigenetic influence on EAE phenotypes induced with different encephalitogenic peptides. J Neuroimmunol. 2000;108:45–52.
  • Pericak-Vance MA, Rimmler JB, Martin ER, Haines JL, Garcia ME, Oksenberge JR, et al. A detailed examination of chromosome 19913 in multiple sclerosis using linkage and association analysis. Neuro genetics. [In press12002.
  • Oksenberg JR, Baranzini SE, Barcellos LF, Hauser SL. Multiple sclerosis. Genomic rewards (Review). J Neuroimmunol. 2001; 113:171–184.
  • Kalman B, Rodriguez-Valdez JL, Bosch U, Lublin PD. Screening for Leber's hereditary optic neuropathy associated mitochondrial DNA mutations in patients with prominent optic neuritis. Multiple Sclerosis. 1997;2:279–282.
  • Rizzo JF, Lessell S. Risk of developing multiple sclerosis after uncomplicated optic neuritis: a long-term prospective study. Neurology. 1988;38:185–190.
  • Beck RW, Arrington J, Murragh FR, Cleary PA, Kaufman DI. Brain magnetic resonance imaging in acute optic neuritis. Experience of the Optic Neuritis Study Group. Arch Neurol. 1993;50:841–846.
  • Beck RW, Trobe JD. The Optic Neuritis Treatment Trial. Putting the results in perspective. The Optic Neuritis Study Group. J Neuroophthalmol. 1995;15:131–135.
  • Kurtzke JF, Beebe GW, Norman Jr JE. Epidemiology of multiple sclerosis in U.S. veterans. 1. Race, sex, and geographic distribution. Neurology. 1979;29(9 Pt 0:1228–1235.
  • Sandberg-Wollheim M, Brynke H, Cronqvist S, Holtas S, Platz P, Ryder LP. A long-term prospective study of optic neuritis: evaluation of risk factors. Ann Neurol. 1990;27: 386–393.
  • Druschky A, Heckmann JG, Claus D, Katalinic A, Druschky KF, Neundorfer B. Progression of optic neuritis to multiple sclerosis: an 8-year follow-up study. Clin Neurol Neurosurg. I999;IoI:189–192.
  • Brex PA, Ciccarelli 0, O'Riordan JI, Sailer M, Thompson AJ, Miller DH. A longitudinal study of abnormalities on MRI and disability from multiple sclerosis. N Engl J Med. 2002;346(3):199–200.
  • Miller DH, Ormerod IE, McDonald WI, MacManus DG, Kendall BE, Kingsley DR The early risk of multiple sclerosis after optic neuritis. J Neurol Neurosurg Psychiatry. 1988;51:1569–1571.
  • Guy J, Fitzsimmons J, Ellis EA, Beck B, Mancuso A. Intraorbital optic nerve and experimental optic neuritis. Correlation of fat suppression magnetic resonance imaging and electron microscopy. Ophthalmology. 1992;99:720–725.
  • Guy J, Mao J, Bidgood Jr WD, Mancuso A, Quisling RG. Enhancement and demyelination of the intraorbital optic nerve. Fat suppression magnetic resonance imaging. Ophthalmology. 1992;99: 713–719.
  • Cornblath WT, Quint DJ. MRI of optic nerve enlargement in optic neuritis. Neurology. 1997;48:821–825.
  • Rolak LA, Beck RW, Paty DW, Tourtellotte WW, Whitaker JN, Rudick RA. Cerebrospinal fluid in acute optic neuritis: experience of the Optic Neuritis Treatment Trial. Neurology. 1996;46:368–372.
  • Ghezzi A, Toni V, Zaffaroni M. Isolated optic neuritis and its prognosis for multiple sclerosis: a clinical and paraclinical study with evoked potentials. CSF examination and brain MRI. Ital J Neurol Sci. 1996;17:325–332.
  • Andersson T, Siden A. An analysis of VEP components in optic neuritis. Electromyogr Clin Neurophysiol. 1995;35:77–85.
  • Spehlmann R. Evoked potential primer, ist ed. Boston, MA: Butterworth Publishers, 1985; 126.
  • Sorensen TL, Frederikson JL, Bronnum-Hansen H, Petersen HC. Optic neuritis as onset manifestation of multiple sclerosis: a nationwide, long-term survey. Neurology. 1999;53:473–478.
  • Cole SR, Beck RW, Moke PS, Kaufinail DI, Tourtellotte WW The predictive value of CSF oligoclonal banding for MS 5 years after optic neuritis. Optic Neuritis Study Group. Neurology. 1998;51:885–887.
  • Beck RW, Cleary FA. Optic neuritis treatment trial. One-year follow-up results [see comments]. Arch Ophthalmol. '993;1'1:773–775.
  • Fleishman JA, Beck RW, Linares DA, Klein JW. Deficits in visual function after resolution of optic neuritis. Ophthalmology. 1987;94: 1029–1035.
  • Franklin CR, Brickner RM. Vasospasm associated with multiple sclerosis. Arch Neurol Psychiatr. 1947;58:125–162.
  • Goldstein JE, Cogan DG. Exercise and the optic neuropathy of multiple sclerosis. Arch Ophthalmol. 1964;72:168–170.
  • Uhthoff W. Untersuchungen uber die bei der multiplen herdsklerose vorkommenden augenstorungen. Arch Psychiatr Nervenkr. 189o;21: 55–116,303–410.
  • Scholl GB, Song H-S, Wray SH. Uhthoff's symptom in optic neuritis: relationship to magnetic resonance imaging and development of multiple sclerosis. Ann Neurol. 1991;30:180–184.
  • Smith JL, Hoyt WF, Susac JO. Ocular fundus in acute Leber optic neuropathy. Arch Ophthalmol. 1973;90:349–354.
  • Nelson D, Jeffreys WH, McDowell E Effect of induced hyperthermia on some neurological diseases. Arch Neurol Psychiatr. 1958;79:31–39.
  • Persson HE, Sachs E. Visual evoked potentials elicited by pattern reversal during provoked visual impairment in multiple sclerosis. Brain. 1981;104:369–382.
  • Dunker S, Wiegand W. Prognostic value of magnetic resonance imaging in monosymptomatic optic neuritis. Ophthalmology. 1996;103: 1768–1773.
  • Cleary FA, Beck RW, Bourque LB, Backlund JC, Miskala PH. Visual symptoms after optic neuritis. Results from the Optic Neuritis Treatment Trial. J Neuroophthalmol. 1997;17: 18–23; quiz 24–28.
  • Kupersmith MJ, Nelson JI, Seiple WH, Can RE. Efectrophysiological confirmation of orientation-specific contrast losses in multiple sclerosis. Ann NY Acad Sci. 1984;436:487–491.
  • Halliday AM, McDonald WI, Mushin J. Delayed visual evoked response in optic neuritis. Lancet. 1972;I:982–985.
  • Frederiksen JL, Petrera J, Larsson HB, Stigsby B, Olesen J. Serial MRI, VEP, SEP and biotesiometry in acute optic neuritis: value of baseline results to predict the development of new lesions at one year follow up. Acta Neurol Scand. 1996;93:246–252.
  • Kurland LT, Beebe GW, Kurtzke JF, Nagler B, Auth TL, Lessen S. Studies on the natural history of multiple sclerosis. 2. The progression of optic neuritis to multiple sclerosis. Acta Neurol Scand.I966;42(Suppl):157+.
  • Morrissey SP, Bormat FX, Miller DH, Moseley IF, Sweeney MG, Govan GG. Bilateral simultaneous optic neuropathy in adults: clinical, imaging, serological, and genetic studies. J Neurol Neurosurg Psychiatry. 1995;58:70–74.
  • Hutchinson WM. Acute optic neuritis and the prognosis for multiple sclerosis. J Neurol Neurosurg Psychiatry. 1976;39: 283–289.
  • Haller P, Patzgold U. Die Optikusneuritis im Kindesalter. Fortschr Neurol Psychiatr. 1979;47: 209–216.
  • Kriss A, Francis DA, Cuendet F, et al. Recovery after optic neuritis in childhood. J Neurol Neurosurg Psychiatry. 1988;51:1253.
  • Riikonen R. The role of infection and vaccination in the genesis of optic neuritis and multiple sclerosis in children. Acta Neurol (Scand). 1989;80:425–431.
  • Kennedy C, Carter S. Relation of optic neuritis to multiple sclerosis in children. Paediatrics. 1961;28:377–387.
  • Kennedy C, Carroll FD. Optic neuritis in children. Arch Ophthalmol. 1960;63:747–755.
  • Riikonen R, Donner M, Errkila H. Optic neuritis in children and its relationship to multiple sclerosis. A clinical study of 21 children. Dev Med Child Neurol. 1988;3o:349–359.
  • Morales DS, Siatkowski RM, Howard CW, Warman R. Optic neuritis in children. J Pediatr Ophthalmol Strabismus. 2000;37(5): 254–259.
  • Beck RW, Cleary FA, Backlund JC. The course of visual recovery after optic neuritis. Experience of the Optic Neuritis Treatment Trial. Ophthalmology. 1994;101:1771–1778.
  • Beck RW, Cleary PA, Trobe JD, Kaufman DR, Kupersmith D, Paty DW. The effect of corticosteroids for acute optic neuritis on the subsequent development of multiple sclerosis. The Optic Neuritis Study Group [see comments]. N Engl J Med. 1993; 329:1764–1769.
  • Beck RW. The optic neuritis treatment trial. Implications for clinical practice. Optic Neuritis Study Group (Editorial). Arch Ophthalmol. I 992; I 10:331–332.
  • Chrousos GA, Katrah JC, Beck RW, Cleary FA. Side effects of glucocorticoid treatment. Experience of the Optic Neuritis Treatment Trial. J Am Med Assoc. 1993;269:2110–2112.
  • Cleary FA, Beck RW, Anerson Jr MM, Kenny DJ, Backlund JY, Gilbert FR. Design, methods, and conduct of the Optic Neuritis Treatment Trial. Control Clin Trials. 1993;14:123–142.
  • Dalakas MC. Intravenous immune globulin therapy for neurologic diseases [see comments]. Ann Intern Med. 1997;126:721–730.
  • Schuller E. [Use of immunoglobulin G in the treatment of nervous system diseases]. Transfus Clin Biol. 1995;2:57–66.
  • Noseworthy JH, O'Brien PC, Petterson TM, Weis J, Stevens L, Peters WK, et al. A randomized trial of intravenous immunoglobulin in inflammatory demyelinating optic neuritis. Neurology. 2001; 56(1 0:14–22.
  • Jacobs LD, Beck RW, Simon JH, Kenkel RP, Brownscheidle CM, Murray TJ, et al. Intramuscular interferon beta-ia therapy initiated during a first demyelinating event in multiple sclerosis. CHAMPS Study Group. N Engl J Med. 2000;343(13):898–904.
  • Galetta SL. The controlled high risk Avonex multiple sclerosis trial (CHAMPS Study). J Neuroophthalmol. 200 I ; (4):292–295.
  • Munschauer 3rd FE, Stuart WH. Rationale for early treatment with interferon beta-ia in relapsing-remitting multiple sclerosis. Clin Ther. 1997;19(5):868–882.
  • Martinelli-Boneschi F, Hartung HP, Sorensen PS, Edan G, Fernandez 0, Durelli L, et al. Baseline variables predictive of conversion from possible to clinically definite MS: ETOMS results. In: American Academy of Neurology 54' Annual Meeting; 13–20 April 2002, Denver, Colorado.
  • Munschauer 3rd FE, Kinkel RP. Managing side effects of interferon-beta in patients with relapsing-remitting multiple sclerosis. Clin Ther. 1997;19(5):883–893.
  • Patten SB, Metz LM. Interferon-beta Ia and depression in secondary progressive MS: data from the SPECTRIMS Trial. Neurology. 2002;59:744–746.
  • Feinstein A, O'Connor P, Feinstein K. Multiple sclerosis, interferon beta- II) and depression: a prospective investigation. J Neurol. 2002;249(7):815–820.
  • Feinstein A. An examination of suicidal intent in patients with multiple sclerosis. Neurology. 2002; 59:674–678.

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