Aortic valve: anatomy and structure and the role of vasculature in the degenerative process

References

• Stewart BF, Siscovick D, Lind BK, et al. Clinical factors associated with calcific aortic valve disease. Cardiovascular health study. J Am Coll Cardiol. 1997;29(3):630–634.
   PubMed Web of Science ®Google Scholar
• Otto CM, Lind BK, Kitzman DW, et al. Association of aortic-valve sclerosis with cardiovascular mortality and morbidity in the elderly. N Engl J Med. 1999;341(3):142–147.
   PubMed Web of Science ®Google Scholar
• Tilea I, Suciu H, Tilea B, et al. 2013. Anatomy and function of normal aortic valvular complex. In: Aikawa E, editor. Calcific aortic valve disease. Intechopen; p. 31–57. Available from: http://dx.doi.org/10.5772/53403
   Google Scholar
• Schoen FJ. Evolving concepts of cardiac valve dynamics: the continuum of development, functional structure, pathobiology, and tissue engineering. Circulation. 2008;118(18):1864–1880.
   PubMed Web of Science ®Google Scholar
• Piazza N, de Jaegere P, Schultz C, et al. Anatomy of the aortic valvar complex and its implications for transcatheter implantation of the aortic valve. Circ Cardiovasc Interv. 2008;1(1):74–81.
   PubMed Web of Science ®Google Scholar
• Cary T, Pearce J. Aortic stenosis: pathophysiology, diagnosis, and medical management of nonsurgical patients. Crit Care Nurse. 2013;33(2):58–72.
   PubMed Web of Science ®Google Scholar
• Misfeld M, Sievers HH. Heart valve macro- and microstructure. Philos Trans R Soc Lond B Biol Sci. 2007;362(1484):1421–1436.
   PubMed Web of Science ®Google Scholar
• Ho SY. Structure and anatomy of the aortic root. Eur J Echocardiogr. 2009;10(1):i3–10.
   PubMed Web of Science ®Google Scholar
• Bateman MG, Quill JL, Hill AJ, et al. The anatomy and function of the semilunar valves. In: Iaizzo PA, Bianco RW, Hill AJ, editors. Heart valves: from design to clinical implantation. St Louis (JD): Springer; 2013. p. 27–43.
   Google Scholar
• Bateman MG1, Hill AJ, Quill JL, et al. The clinical anatomy and pathology of the human arterial valves: implications for repair or replacement. J Cardiovasc Transl Res. 2013;6(2):166–175.
   PubMed Web of Science ®Google Scholar
• Charitos EI, Sievers HH. Anatomy of the aortic root: implications for valve-sparing surgery. Ann Cardiothorac Surg. 2013;2(1):53–56.
   PubMedGoogle Scholar
• Hoffman JI, Kaplan S. The incidence of congenital heart disease. J Am Coll Cardiol. 2002;39(12):1890–1900.
   PubMed Web of Science ®Google Scholar
• Novaro GM, Katz R, Aviles RJ, et al. Clinical factors, but not C-reactive protein, predict progression of calcific aortic-valve disease: the Cardiovascular Health Study. J Am Coll Cardiol. 2007;50(20):1992–1998.
   PubMed Web of Science ®Google Scholar
• Bonow RO, Carabello B, de Leon AC, Jr, et al. Guidelines for the management of patients with valvular heart disease: executive summary. A report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (Committee on Management of Patients with Valvular Heart Disease). Circulation. 1998;98(18):1949–1984.
   PubMed Web of Science ®Google Scholar
• Vahanian A, Alfieri O, Andreotti F, et al. Guidelines on the management of valvular heart disease (version 2012). Eur Heart J. 2012;33(19):2451–2496.
   PubMed Web of Science ®Google Scholar
• Hinton RB, Yutzey KE. Heart valve structure and function in development and disease. Annu Rev Physiol. 2011;73:29–46.
   PubMed Web of Science ®Google Scholar
• Leopold JA. Cellular mechanisms of aortic valve calcification. Circ Cardiovasc Interv. 2012;5(4):605–614.
   PubMed Web of Science ®Google Scholar
• Akahori H, Tsujino T, Masuyama T, et al. Mechanisms of aortic stenosis. J Cardiol. 2018;71(3):215–220.
   PubMed Web of Science ®Google Scholar
• Syväranta S, Helske S, Laine M, et al. Vascular endothelial growth factor-secreting mast cells and myofibroblasts: a novel self-perpetuating angiogenic pathway in aortic valve stenosis. Arterioscler Thromb Vasc Biol. 2010;30(6):1220–1227.
   PubMed Web of Science ®Google Scholar
• Freeman RV, Otto CM. Spectrum of calcific aortic valve disease: pathogenesis, disease progression, and treatment strategies. Circulation. 2005;111(24):3316–3326.
   PubMed Web of Science ®Google Scholar
• Otto CM, Kuusisto J, Reichenbach DD, et al. Characterization of the early lesion of ‘degenerative’ valvular aortic stenosis. Histological and immunohistochemical studies. Circulation. 1994;90(2):844–853.
   PubMed Web of Science ®Google Scholar
• Alexopoulos A, Kaoukis A, Papadaki H, et al. Pathophysiologic mechanisms of calcific aortic stenosis. Ther Adv Cardiovasc Dis. 2012;6(2):71–80.
   PubMedGoogle Scholar
• Mohler ER, Gannon F, Reynolds C, et al. Bone formation and inflammation in cardiac valves. Circulation. 2001;103(11):1522–1528.
   PubMed Web of Science ®Google Scholar
• Mazzone A, Epistolato MC, De Caterina R, et al. Neoangiogenesis, T-lymphocyte infiltration, and heat shock protein-60 are biological hallmarks of an immunomediated inflammatory process in end-stage calcified aortic valve stenosis. J Am Coll Cardiol. 2004;43(9):1670–1676.
   PubMed Web of Science ®Google Scholar
• Clarke JA. An x-ray microscopic study of the blood supply to the valves of the human heart. Br Heart J. 1965;27(3):420–423.
   PubMedGoogle Scholar
• Charest A, Pépin A, Shetty R, et al. Distribution of SPARC during neovascularisation of degenerative aortic stenosis. Heart. 2006;92(12):1844–1849.
   PubMed Web of Science ®Google Scholar
• Soini Y, Salo T, Satta J. Angiogenesis is involved in the pathogenesis of nonrheumatic aortic valve stenosis. Hum Pathol. 2003;34(8):756–763.
   PubMed Web of Science ®Google Scholar
• Chalajour F, Treede H, Ebrahimnejad A, et al. Angiogenic activation of valvular endothelial cells in aortic valve stenosis. Exp Cell Res. 2004;298(2):455–464.
   PubMed Web of Science ®Google Scholar
• Fondard O, Detaint D, Iung B, et al. Extracellular matrix remodelling in human aortic valve disease: the role of matrix metalloproteinases and their tissue inhibitors. Eur Heart J. 2005;26(13):1333–1341.
   PubMed Web of Science ®Google Scholar
• Rajamannan NM, Nealis TB, Subramaniam M, et al. Calcified rheumatic valve neoangiogenesis is associated with vascular endothelial growth factor expression and osteoblast-like bone formation. Circulation. 2005;111(24):3296–3301.
   PubMed Web of Science ®Google Scholar
• Yoshioka M, Yuasa S, Matsumura K, et al. Chondromodulin-I maintains cardiac valvular function by preventing angiogenesis. Nat Med. 2006;12(10):1151–1159.
   PubMed Web of Science ®Google Scholar
• Steiner I, Krbal L, Dominik J. Blood vessels and lymphatics in calcific aortic stenosis–in support of its inflammatory pathogenesis. Cesk Patol. 2010;46(2):33–36.
   PubMedGoogle Scholar
• Moreno PR, Purushothaman M, Purushothaman KR. Plaque neovascularization: defense mechanisms, betrayal, or a war in progress. Ann N Y Acad Sci. 2012;1254:7–17.
   PubMed Web of Science ®Google Scholar
• Moreno PR, Purushothaman KR, Zias E, et al. Neovascularization in human atherosclerosis. Curr Mol Med. 2006;6(5):457–477.
   PubMed Web of Science ®Google Scholar
• Camaré C, Pucelle M, Nègre-Salvayre A, et al. Angiogenesis in the atherosclerotic plaque. Redox Biol. 2017;12:18–34.
   PubMed Web of Science ®Google Scholar
• Ribatti D, Levi-Schaffer F, Kovanen PT. Inflammatory angiogenesis in atherogenesis–a double-edged sword. Ann Med. 2008;40(8):606–621.
   PubMed Web of Science ®Google Scholar
• Kaur S, Anita K. Angiogenesis in liver regeneration and fibrosis: “a double-edged sword.” Hepatol Int. 2013;7(4):959–968.
   PubMed Web of Science ®Google Scholar
• Arroyo AG, Iruela-Arispe ML. Extracellular matrix, inflammation, and the angiogenic response. Cardiovasc Res. 2010;86(2):226–235.
   PubMed Web of Science ®Google Scholar
• Rundhaug JE. Matrix metalloproteinases and angiogenesis. J Cell Mol Med. 2005;9(2):267–285.
   PubMed Web of Science ®Google Scholar
• Davis GE, Senger DR. Endothelial extracellular matrix: biosynthesis, remodeling, and functions during vascular morphogenesis and neovessel stabilization. Circ Res. 2005;97(11):1093–1107.
   PubMed Web of Science ®Google Scholar
• Kwon TG, Lerman LO, Lerman A. The vasa vasorum in atherosclerosis: the vessel within the vascular wall. J Am Coll Cardiol. 2015;65(23):2478–2480.
   PubMed Web of Science ®Google Scholar
• Sverdlov AL, Ngo DT, Chapman MJ, et al. Pathogenesis of aortic stenosis: not just a matter of wear and tear. Am J Cardiovasc Dis. 2011;1(2):185–199.
   PubMedGoogle Scholar
• Parolari A, Loardi C, Mussoni L, et al. Nonrheumatic calcific aortic stenosis: an overview from basic science to pharmacological prevention. Eur J Cardiothorac Surg. 2009;35(3):493–504.
   PubMed Web of Science ®Google Scholar
• Rajamannan NM. Calcific aortic stenosis: lessons learned from experimental and clinical studies. Arterioscler Thromb Vasc Biol. 2009;29(2):162–168. Epub 2008 Nov 20.
   PubMed Web of Science ®Google Scholar
• Sathyamurthy I, Alex S. Calcific aortic valve disease: is it another face of atherosclerosis? Indian Heart J. 2015;67(5):503–506.
   PubMedGoogle Scholar
• Weind KL, Ellis CG, Boughner DR. Aortic valve cusp vessel density: relationship with tissue thickness. J Thorac Cardiovasc Surg. 2002;123(2):333–340.
   PubMed Web of Science ®Google Scholar
• Sapp MC, Krishnamurthy VK, Puperi DS, et al. Differential cell-matrix responses in hypoxia-stimulated aortic versus mitral valves. J R Soc Interface. 2016;13(125):pii:20160449.
   PubMed Web of Science ®Google Scholar
• Skowasch D, Schrempf S, Wernert N, et al. Cells of primarily extra-valvular origin in degenerative aortic valves and bioprostheses. Eur Heart J. 2005;26(23):2576–2580.
   PubMed Web of Science ®Google Scholar
• Chalajour F, Treede H, Gehling UM, et al. Identification and characterization of cells with high angiogenic potential and transitional phenotype in calcific aortic valve. Exp Cell Res. 2007;313(11):2326–2335.
   PubMed Web of Science ®Google Scholar
• Durbin AD, Gotlieb AI. Advances towards understanding heart valve response to injury. Cardiovasc Pathol. 2002;11(2):69–77.
   PubMed Web of Science ®Google Scholar
• Hayoz D, Mazzolai L. Endothelial function, mechanical stress and atherosclerosis. Adv Cardiol. 2007;44:62–75.
   PubMed Web of Science ®Google Scholar
• Hadi HA, Carr CS, Al Suwaidi J. Endothelial dysfunction: cardiovascular risk factors, therapy, and outcome. Vasc Health Risk Manag. 2005;1(3):183–198.
   PubMedGoogle Scholar
• Coté N, Mahmut A, Bosse Y, et al. Inflammation is associated with the remodeling of calcific aortic valve disease. Inflammation. 2013;36(3):573–581.
   PubMed Web of Science ®Google Scholar
• Syväranta S, Alanne-Kinnunen M, Oörni K, et al. Potential pathological roles for oxidized low-density lipoprotein and scavenger receptors SR-AI, CD36, and LOX-1 in aortic valve stenosis. Atherosclerosis. 2014;235(2):398–407.
   PubMed Web of Science ®Google Scholar
• Hakuno D, Kimura N, Yoshioka M, et al. Periostin advances atherosclerotic and rheumatic cardiac valve degeneration by inducing angiogenesis and MMP production in humans and rodents. J Clin Invest. 2010;120(7):2292–2306.
   PubMed Web of Science ®Google Scholar
• Perrotta I, Moraca FM, Sciangula A, et al. HIF-1α and VEGF: immunohistochemical profile and possible function in human aortic valve stenosis. Ultrastruct Pathol. 2015;39(3):198–206.
   PubMed Web of Science ®Google Scholar
• Akahori H, Tsujino T, Naito Y, et al. Nuclear factor-κB-hypoxia-inducible factor-2 pathway in aortic valve stenosis. J Heart Valve Dis. 2014;23(5):558–566.
   PubMed Web of Science ®Google Scholar
• Helske S, Syväranta S, Lindstedt KA, et al. Increased expression of elastolytic cathepsins S, K, and V and their inhibitor cystatin C in stenotic aortic valves. Arterioscler Thromb Vasc Biol. 2006;26(8):1791–1798.
   PubMed Web of Science ®Google Scholar
• Peltonen T, Näpänkangas J, Vuolteenaho O, et al. Apelin and its receptor APJ in human aortic valve stenosis. J Heart Valve Dis. 2009;18(6):644–652.
   PubMed Web of Science ®Google Scholar
• Pohjolainen V, Mustonen E, Taskinen P, et al. Increased thrombospondin-2 in human fibrosclerotic and stenotic aortic valves. Atherosclerosis. 2012;220(1):66–71.
   PubMed Web of Science ®Google Scholar
• Rajamannan NM, Subramaniam M, Rickard D, et al. Human aortic valve calcification is associated with an osteoblast phenotype. Circulation. 2003;107(17):2181–2184.
   PubMed Web of Science ®Google Scholar
• Satta J, Melkko J, Pöllänen R, et al. Progression of human aortic valve stenosis is associated with tenascin-C expression. J Am Coll Cardiol. 2002;39(1):96–101.
   PubMed Web of Science ®Google Scholar
• Akahori H, Tsujino T, Naito Y, et al. Intraleaflet haemorrhage is associated with rapid progression of degenerative aortic valve stenosis. Eur Heart J. 2011;32(7):888–896.
   PubMed Web of Science ®Google Scholar
• Akahori H, Tsujino T, Naito Y, et al. Intraleaflet haemorrhage as a mechanism of rapid progression of stenosis in bicuspid aortic valve. Int J Cardiol. 2013;167(2):514–518.
   PubMed Web of Science ®Google Scholar
• Collett GD, Canfield AE. Angiogenesis and pericytes in the initiation of ectopic calcification. Circ Res. 2005;96(9):930–938.
   PubMed Web of Science ®Google Scholar
• Lindroos M, Kupari M, Heikkilä J, et al. Prevalence of aortic valve abnormalities in the elderly: an echocardiographic study of a random population sample. J Am Coll Cardiol. 1993;21(5):1220–1225.
   PubMed Web of Science ®Google Scholar
• Bonetti PO, Lerman LO, Napoli C, et al. Statin effects beyond lipid lowering–are they clinically relevant? Eur Heart J. 2003;24(3):225–248.
   PubMed Web of Science ®Google Scholar
• Chan KL, Teo K, Dumesnil JG, et al. Effect of Lipid lowering with rosuvastatin on progression of aortic stenosis: results of the aortic stenosis progression observation: measuring effects of rosuvastatin (ASTRONOMER) trial. Circulation. 2010;121(2):306–314.
   PubMed Web of Science ®Google Scholar
• Cowell SJ, Reid J, Northridge DB, et al. Boon NA; Scottish aortic stenosis and lipid lowering trial, impact on regression (SALTIRE) investigators. A randomized trial of intensive lipid-lowering therapy in calcific aortic stenosis. N Engl J Med. 2005;352(23):2389–2397.
   PubMed Web of Science ®Google Scholar
• Rossebø AB, Skjaerpe T, Wachtell K, et al. Willenheimer R; SEAS investigators. Intensive lipid lowering with simvastatin and ezetimibe in aortic stenosis. N Engl J Med. 2008;359(13):1343–1356.
   PubMed Web of Science ®Google Scholar
• Catapano AL, Graham I, De Backer G, et al. 2016 ESC/EAS guidelines for the management of dyslipidaemias. Eur Heart J. 2016;37(39):2999–3058.
   PubMed Web of Science ®Google Scholar
• Vuorio T, Jauhiainen S, Ylä-Herttuala S. Pro- and anti-angiogenic therapy and atherosclerosis with special emphasis on vascular endothelial growth factors. Expert Opin Biol Ther. 2012;12(1):79–92.
   PubMed Web of Science ®Google Scholar
• Salo T, Soini Y, Oiva J, et al. Chemically modified tetracyclines (CMT-3 and CMT-8) enable control of the pathologic remodellation of human aortic valve stenosis via MMP-9 and VEGF inhibition. Int J Cardiol. 2006;111(3):358–364.
   PubMed Web of Science ®Google Scholar
• Waters EA, Chen J, Allen JS, et al. Detection and quantification of angiogenesis in experimental valve disease with integrin-targeted nanoparticles and 19-fluorine MRI/MRS. J Cardiovasc Magn Reson. 2008;10:43.
   PubMed Web of Science ®Google Scholar