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Review Article

Does the long-term administration of proton pump inhibitors increase the risk of adverse cardiovascular outcomes? A ChatGPT powered umbrella review

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Pages 980-988 | Received 11 Apr 2023, Accepted 26 Jun 2023, Published online: 11 Jul 2023

References

  • Mishuk AU, Chen L, Gaillard P, et al. National trends in prescription proton pump inhibitor use and expenditure in the United States in 2002-2017. J Am Pharm Assoc. 2003;S1544-3191(20)30476-3.
  • Daniels B, Pearson SA, Buckley NA, et al. Long-term use of proton-pump inhibitors: whole-of-population patterns in Australia 2013-2016. Therap Adv Gastroenterol. 2020;13:1756284820913743. doi:10.1177/1756284820913743.
  • Mazer-Amirshahi M, Mullins PM, van den Anker J, et al. Rising rates of proton pump inhibitor prescribing in US emergency departments. Am J Emerg Med. 2014;32(6):618–622. doi:10.1016/j.ajem.2014.03.019.
  • Lee D, Kim JS, Kim BJ, et al. Influence of individual proton pump inhibitors on clinical outcomes in patients receiving clopidogrel following percutaneous coronary intervention. Medicine (Baltimore). 2021;100(52):e27411. doi:10.1097/MD.0000000000027411.
  • Malhotra K, Katsanos AH, Bilal M, et al. Cerebrovascular outcomes with proton pump inhibitors and thienopyridines: a systematic review and Meta-Analysis. Stroke. 2018;49(2):312–318. doi:10.1161/STROKEAHA.117.019166.
  • Serbin MA, Guzauskas GF, Veenstra DL. Clopidogrel-Proton pump inhibitor Drug-Drug interaction and risk of adverse clinical outcomes among PCI-Treated ACS patients: a meta-analysis. JMCP. 2016;22(8):939–947. doi:10.18553/jmcp.2016.22.8.939.
  • Demcsák A, Lantos T, Bálint ER, et al. PPIs are not responsible for elevating cardiovascular risk in patients on Clopidogrel-A systematic review and Meta-Analysis. Front Physiol. 2018;9:1550. doi:10.3389/fphys.2018.01550.
  • Khan MY, Siddiqui WJ, Alvarez C, et al. Reduction in postpercutaneous coronary intervention angina in addition to gastrointestinal events in patients on combined proton pump inhibitors and dual antiplatelet therapy: a systematic review and meta-analysis. Eur J Gastroenterol Hepatol. 2018;30(8):847–853. doi:10.1097/MEG.0000000000001125.
  • Guo H, Ye Z, Huang R. Clinical outcomes of concomitant use of proton pump inhibitors and dual antiplatelet therapy: a systematic review and Meta-Analysis. Front Pharmacol. 2021;12:694698. doi:10.3389/fphar.2021.694698.
  • Page MJ, McKenzie JE, Bossuyt PM, et al. The PRISMA 2020 statement: an updated guideline for reporting systematic reviews. BMJ. 2021;372:n71. doi:10.1136/bmj.n71.
  • Shea BJ, Reeves BC, Wells G, et al. AMSTAR 2: a critical appraisal tool for systematic reviews that include randomised or non-randomised studies of healthcare interventions, or both. BMJ. 2017;358:j4008. doi:10.1136/bmj.j4008.
  • Nolde M, Ahn N, Dreischulte T, et al. Proton pump inhibitors and the risk of cardiovascular events and cardiovascular mortality: a systematic review and meta-analysis of observational studies. Eur J Intern Med. 2022;106:80–89. doi:10.1016/j.ejim.2022.09.021.
  • Batchelor R, Kumar R, Gilmartin-Thomas JFM, et al. Systematic review with meta-analysis: risk of adverse cardiovascular events with proton pump inhibitors independent of clopidogrel. Aliment Pharmacol Ther. 2018;48(8):780–796. doi:10.1111/apt.14955.
  • Farhat N, Fortin Y, Haddad N, et al. Systematic review and meta-analysis of adverse cardiovascular events associated with proton pump inhibitors used alone or in combination with antiplatelet agents. Crit Rev Toxicol. 2019;49(3):215–261. doi:10.1080/10408444.2019.1583167.
  • Sun S, Cui Z, Zhou M, et al. Proton pump inhibitor monotherapy and the risk of cardiovascular events in patients with gastro-esophageal reflux disease: a meta-analysis. Neurogastroenterol Motil. 2017;29(2):e12926. doi:10.1111/nmo.12926.
  • Yang M, He Q, Gao F, et al. Regular use of proton-pump inhibitors and risk of stroke: a population-based cohort study and meta-analysis of randomized-controlled trials. BMC Med. 2021;19(1):316. doi:10.1186/s12916-021-02180-5.
  • Shiraev TP, Bullen A. Proton pump inhibitors and cardiovascular events: a systematic review. Heart Lung Circ. 2018;27(4):443–450. doi:10.1016/j.hlc.2017.10.020.
  • Li S, Liu F, Chen C, et al. Real-World relationship between proton pump inhibitors and Cerebro-Cardiovascular outcomes independent of clopidogrel. Int Heart J. 2019;60(4):910–918. doi:10.1536/ihj.18-584.

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