The Role of Iodine in Antisepsis and Wound Management: A Reappraisal

References

• Fleischer W., Reimer K. Povidone-Iodine in Antisepsis-State of the Art. Dermatology, 1997, 195 (suppl 2): 3–9.
   Google Scholar
• Gershenfeld L. Povidone-iodine as a topical antiseptic. Am J Surg, 1957, 94: 938–939.
   Google Scholar
• Davaine M. D. Recherches sur le traitment des maladies charbonneuses chez l’homme. Bull Acad Natl Med Paris, 1880, 9: 757.
   Google Scholar
• Gulliver G. Wound Care. Arguments over iodine. Nursing Time, 1999, 95 (27): 68–70.
   Google Scholar
• Schelanski H. A., Shelanski M. V. PVP-iodine: History, toxicity and therapeutic uses. J Int Coll Surg, 1956, 25: 727–737.
   Google Scholar
• Lawrence J. C. The use of iodine as an antiseptic agent. J Wound Care, 1998, 7 (8): 421–5.
   Google Scholar
• Reynolds J. The Extra Pharmacopoeia (29th edn). Martindale eds. London: The Pharmaceutical Press, 1989.
   Google Scholar
• Gottardi W. Iodine and iodine compounds. In S.S. Block eds. Disinfection, sterilization, and preservation. 4th ed. Lea & Febiger, Philadelphia, Pa., 1991: 152–166.
   Google Scholar
• Higgins D. G. Povidone iodine: the tamed iodine. Chemist and Druggist, 1975, August 30, 274–275.
   Google Scholar
• Lacey R. W., Catto A. Action of povidone-iodine against methi-cillin sensitive and-resistant cultures of Staphylococcus aureus. Postgrad Med J, 1993, 69: (suppl 3), S78–S83.
   Google Scholar
• Berkelman R. L., Holland B. W., Handerson R. L. Increased bactericidal activity of dilute preparations of povidone-iodine solutions. J Clin Microbiol, 1982, 15: 635–639.
   Google Scholar
• Rackur H. New aspects of mechanism of action of povidoneiodine. J Hosp Infect, 1985, 6 (suppl A): 13–23.
   Google Scholar
• Mayer D. A. Povidone-Iodine and Wound Healing: A Critical Review. Wounds, 1993, 5 (1): 14–23.
   Google Scholar
• Jeng D. K., Severin J. E. Povidone iodine gel alcohol: a 30-second onetime application preoperative skin preparation. Am J Infect Control, 1998 Oct, 26 (5): 488–94.
   Google Scholar
• Cahuzac J. P., Lareng B., Prere M. F., Denis P., Greig G. Evaluation de l’activité bactericide de la PVP-I at de la chlorhexidine. Therapeutique, Abstract Hospital N 11, Oct, 1991: 27–30.
   Google Scholar
• Reverdy M. E., Martra A., Allaert F. A., Nony P., Freney J. Cinetique de bactericide de la PVP-I, solution dermique, sur la flore residente du pli du coude, après application de 15 ou 30 secondes. Med Mal Infect, 1997, 27: 711–4.
   Google Scholar
• Calfee D. P., Farr B. M. Comparison of four antiseptic preparations for skin in the prevention of contamination of percutaneously drawn blood cultures: a randomized trial. J Clin Microbiol, 2002 May, 40 (5): 1660–5.
   Google Scholar
• Arata T., Murakami T., Hirai Y. Evaluation of povidone-iodine alcoholic solution for operative site disinfection. Postgrad Med J, 1993, 69 Suppl 3: S93–6.
   Google Scholar
• Kutarski P. W., Grundy H. C. To dry or not to dry? An assessment of the possible degradation in efficiency of preoperative skin preparation caused by wiping skin dry. Annals of Royal College of Surgeons of England (1993) vol. 75, 181–185.
   Google Scholar
• Sundberg J. A retrospective review of cadexomer iodine in the treatment of chronic wounds. Wounds, 1997, 9: 68–86.
   Google Scholar
• Gordon J. Clinical significance of methicillin-sensitive and methi-cillin-resistant Staphylococcus aureus in UK hospitals and the relevance of povidone-iodine in their control. Postgrad Med J, 1993, 69 (suppl 3): 106–115.
   Google Scholar
• Prince H. N., Prince D. L., Prince R. N. Principles of viral control and transmission. In: Block S. S. (eds.). Disinfection, sterilization, and preservation. 4th ed. Lea & Febiger, Philadelphia, Pa, 1991: 441–444.
   Google Scholar
• Springthorpe V. S., Satter S. A. Chemical disinfection of virus-contaminated surfaces. Crit Rev Environ Control, 1990, 20: 169229.
   Google Scholar
• Rutala W. A. APIC guidelines for selection and use of disinfectants. Am J Infect Control, 1995, 23: 313–342.
   Google Scholar
• Larson E. L. Antiseptics. In: Olmstad R. N. (ed.). APIC infection control & applied epidemiology: principles & practices. Mosby-Year Book, Inc., St. Louis, Mo., 1996: 19–1, 19–7, G1–G17.
   Google Scholar
• Munson. Principles of Pharmacology, Chapman & Hall, 1995.
   Google Scholar
• Pierard G. E., Pierard-Franchimont C., Arrese J. E. Povidoneiodine wash solution in the prevention of superficial fungal infections, predictive evaluation using the corneofungimetry bioassay. Eur J Clin Pharmacol, 1997, 53 (2): 101–104.
   Google Scholar
• Goldenheim D. In vitro efficacy of povidone-iodine solution and cream against methicillin-resistant Staphylococcus aureus. Postgrad Med J, 1993, 69 (suppl.3): S62–S65.
   Google Scholar
• McLure A. R. In-vitro evaluation of povidone-iodine and chlorexidine against methicilin-resistant Staphylococcus aureus. J of Hospital Infection, 1992, 21: 291–299.
   Google Scholar
• Block C., Robenshtok E., Simhon ॅ., Shapiro M. Evaluation of chlorexidine and povidone iodine activity against methicillin-resistant Staphylococcus aureus and vancomycin-resistant Enterococcus faecalis using a surface test. J Hosp Infect, 2000 oct, 46 (2): 147–152.
   Google Scholar
• McDonnel G., Russel D. Antiseptics and Disinfectants: activity, action and resistance. Clinical Microbiology Reviews, 1999 Jan: 147–179.
   Google Scholar
• Kunisada T., Yamada K., Oda S., Hara O. Investigation on the efficacy of povidone-iodine against antiseptic-resistant species. Dermatology, 1997, 195 (suppl 2): 14–8.
   Google Scholar
• Kramer S. ॅ. Effect of povidone-iodine on wound healing:a review. J Vasc Nurs, 1999 Mar, 17 (1): 17–23.
   Google Scholar
• Lineaweaver W., Howard R., Soucy D., McMorris S., Freeman J., Crain C., Robertson J., Rumley T. Topical Antimicrobial Toxicity. Arch Surg, 1985, 120 (3): 267–270.
   Google Scholar
• Gilchrist B. Should iodine be reconsidered in wound management? Journal of wound care, 1997, 6 (3): 148–150.
   Google Scholar
• Moore K. Iodine Realeased from the Wound Dressing Iodosorb Modulates the Secretion of Cytokines by Human Macrophages responding to Bacterial Lipopolysaccharide. Int Biochem Cell Biol, 1997, 29 (1): 163–171.
   Google Scholar
• Bennet L. L., Rosenblum R. S., Perlov C., Davidson J. M., Barton R. M., Nanney L. B. An in vivo comparison of topical agents on wound repair. Plastic and Reconstructive Surgery, 2001 Sep, 108 (3): 675–685.
   Google Scholar
• Fumal I., Braham C., Paquet P., Pierard-Freanchimont C., Pierard G. E. The beneficial toxicity paradox of antimicrobials in leg ulcer healing impaired by a polymicrobial flora: a proof-of-concept study. Dermatology, 2002, 204 Suppl 1:70–4.
   Google Scholar
• Schmidt R., Kirby ॅ., Chung L. Cadexomer iodine formulations may modulate the redox environment of wounds. in: iodine and Wound Physiology. Cambridge: Information Transfer Ltd, 1995.
   Google Scholar
• Russel ॅ. D., Day M. J. Antibiotic and biocide resistance in bacteria. Microbios, 1996, 85 (342): 45–65.
   Google Scholar
• Heir E., Langsrud S., Sidhu M. S., Steinbakk M. Can disinfectants contribute to antibiotic resistance? Tidsskr Nor Laegeforen, 2001, 121 (27): 3201–6.
   Google Scholar
• Jones R. D. Bacterial resistance and topical antimicrobial wash products. Am J Infect Control, 1999, 27 (4): 351–363.
   Google Scholar
• Lanker Klossner B., Widmer H. R., Frey F. Nondevelopment of Resistance by Bacteria during Hospital Use of Povidone-Iodine. Dermatology, 1997, 195 (suppl 2): 10–13.
   Google Scholar
• Micock G. Methicillin/antiseptic-resistant Staphylococcus aureus. Lancet, 1985 Oct 26, 2 (8461): 949–50.
   Google Scholar
• Shirashi T., Oka R., Nakagawa Y. Pharmaceutical and bacteriological study on povidone-iodine sugar ointment. Dermatology, 1997, 195 (Suppl 2): 100–3.
   Google Scholar
• Payne D. N., Gibson S. ॅ. W., Lewis R. Antiseptics: a forgotten weapon in the control of antibiotic resistant bacteria in hospital and community settings? J Roy Soc Health, 1998, 118 (1): 18–22.
   Google Scholar
• Campistol J. M., Abad C., Nogue S., Bertran ॅ. Acute renal failure in a patient treated by continuous povidone-iodine mediastinal irrigation. J cardiovasc Surg Torino, 1988, 28: 410–412.
   Google Scholar
• Zec N., Donovan J. W., Aufiero T. X., Kincaid R. L., Demers L. M. Seizures in a patient treated with continuous povidone-iodine mediastinal irrigation (letter). N Engl J Med, 1992, 326:1784).
   Google Scholar
• Keating J. P., Neill M., Hill G. L. Sclerosing encapsulationg peritonitis after intraperitoneal use of povidone iodine. Aust NZ J Surg, 1997, 67: 742–744.
   Google Scholar
• Linder N., Davidovitch N., Reichman B., Kuint J., Hegesh J., Lubin D., Sack J. Topical iodine-containing antiseptics and subclinical hypothyroidism in preterm infants. J Pediatr, 1997, 131: 434–439.
   Google Scholar
• Brown R. S., Bloomfield S., Bednarek F. J., Mitchell M. L., Braverman L. E. Routine skin cleansing with povidone-iodine is not a common cause of transient neonatal hypothyroidism in North America: ॅ retrospective controlled study. Thyroid, 1997, 7: 395–400.
   Google Scholar
• Steen M. Review of the use of povidone-iodine (PVP-I) in the treatment of burns. Postgrad Med J, 1993, 69 (suppl) 3: S84–92.
   Google Scholar
• Okano M. Irritant contact dermatitis caused by povidone-iodine (letter). J Am Acad Dermatol, 1989, 20: 860.
   Google Scholar
• Tosti ॅ., Vincenzi C., Bardazzi F., Mariani R. Allergic contact dermatitis due to povidone-iodine. Contact Dermatitis, 1990, 23: 197–198.
   Google Scholar
• Pohl-Markl H., Neumann R. Polyvinylpyrrolidon-Jod (PVP-Jod) Seine Bedeutung fur die Dermatologie. Z Hautkr, 1988, 63: 1009–1015.
   Google Scholar
• Juhasz I. Experiences with the use of povidone-iodine-containing local therapeutics in dermatological surgery and in the treatment of burns: testing for allergic sensitization in postsurgery patients. Dermatology, 2002, 204 Suppl. 1: 52–8.
   Google Scholar
• Shetty K. R., Duthie E. H. Jr. Thyrotoxicosos induced by topical iodine application. Arch Intern Med, 1990, 150: 2400–2401.
   Google Scholar