Mid-trimester serum relaxin concentrations and post-partum pelvic floor dysfunction

References

• Mant J, Painter R, Vessey M. Epidemiology of genital prolapse: observations from the Oxford family planning association study. BJOG. 1997; 104(5)579–85
   Web of Science ®Google Scholar
• Stanton SL, Kerr-Wilson R, Grant HV. The incidence of urological symptoms in normal pregnancy. BJOG. 1980; 87(10)897–900
   Web of Science ®Google Scholar
• Emmi AM, Skurnick J, Goldsmith LT, Gagliardi CL, Schmidt CL, Kleinberg D, et al. Ovarian control of pituitary hormone secretion in early human pregnancy. J Clin Endocrinol Metab 1991; 72(6)1359–63
   PubMed Web of Science ®Google Scholar
• Bell RJ, Eddie LW, Lester AR, Wood EC, Johnston PD, Niall HD. Relaxin in human pregnancy serum measured with a homologous radioimmunoassay. Obstet Gynecol. 1987; 69(4)585–9
   PubMed Web of Science ®Google Scholar
• MacLennan AH, Nicolson R, Green RC. Serum relaxin in pregnancy. Lancet. 1986; 2(8501)241–3
   PubMed Web of Science ®Google Scholar
• Petersen LK, Vogel I, Agger AO, Westergard J, Nils M, Uldbjerg N. Variations in serum relaxin (hRLX-2) concentrations during human pregnancy. Acta Obstet Gynecol Scand. 1995; 74(4)251–6
   PubMed Web of Science ®Google Scholar
• Sherwood OD. Relaxin's physiological roles and other diverse actions. Endocr Rev. 2004; 25(2)205–34
   PubMed Web of Science ®Google Scholar
• Kristiansson P, Samuelsson E, Von Schoultz B, Svardsudd K. Reproductive hormones and stress urinary incontinence in pregnancy. Acta Obstet Gynecol Scand. 2001; 80(12)1125–30
   PubMed Web of Science ®Google Scholar
• Tincello DG, Teare J, Fraser WD. Second trimester concentration of relaxin and pregnancy related incontinence. Eur J Obstet Gynecol Reprod Biol. 2003; 106(2)237–8
   PubMed Web of Science ®Google Scholar
• Davies G, Ottenhof C, Woodman M, Farley A, Julien N, van Vugt D Cervical length and relaxin as predictors of preterm birth. JOGC. (In press)
   Google Scholar
• Uebersax JS, Wyman JF, Shumaker SA, McClish DK, Fantl JA. Short forms to assess life quality and symptom distress for urinary-incontinence in women – the Incontinence Impact Questionnaire and the Urogenital Distress Inventory. Neurourol Urodyn. 1995; 14(2)131–9
   PubMed Web of Science ®Google Scholar
• Bump RC, Mattiasson A, Bo K, Brubaker LP, Delancey JOL, Klarskov P, et al. The standardization of terminology of female pelvic organ prolapse and pelvic floor dysfunction. Am J Obstet Gynecol. 1996; 175(1)10–17
   PubMed Web of Science ®Google Scholar
• Dupont WD, Plummer WD., Jr. Power and sample size calculations. A review and computer program. Control Clin Trials. 1990; 11(2)116–28
   PubMedGoogle Scholar
• Meyer S, Hohlfeld P, Achtari C, Russolo A, De Grandi P. Birth trauma: short and long term effects of forceps delivery compared with spontaneous delivery on various pelvic floor parameters. BJOG. 2000; 107(11)1360–5
   PubMed Web of Science ®Google Scholar
• Abrams P, Cardozo L, Fall M, Griffiths D, Rosier P, Ulmsten U, et al. The standardization of terminology of lower urinary tract function. Neurourol Urodyn. 2002; 21: 167–78
   PubMed Web of Science ®Google Scholar
• Hunskaar S, Burgio KLP, Clark AL, Lapitan MC, Nelson RL, Sillen U, . Epidemiology of urinary (UI) and fecal (FI) incontinence and pelvic organ prolapse (POP). Incontinence. Third International Consultation on Incontinence, P Abrams, L Cardozo, S Khoury, A Wein, et al. Health Publications, West Caldwell 2004; 255–312
   Google Scholar
• Harvey MA. Genital prolapse following childbirth: a study of its incidence and determinants. Masters of Science, University of Ottawa; 2005.
   Google Scholar
• Nara BS, Welk FA, Rutherford JE, Sherwood OD, First NL. Effect of relaxin on parturition and frequency of live births in pigs. J Reprod Fertil. 1982; 66(1)359–65
   PubMedGoogle Scholar
• Downing SJ, Sherwood OD. The physiological role of relaxin in the pregnant rat. IV. The influence of relaxin on cervical collagen and glycosaminoglycans. Endocrinology. 1986; 118(2)471–9
   PubMed Web of Science ®Google Scholar
• Zhao S, Sherwood OD. Monoclonal antibodies specific for rat relaxin. X. Endogenous relaxin induces changes in the histological characteristics of the rat vagina during the second half of pregnancy. Endocrinology. 1998; 139(11)4726–34
   PubMed Web of Science ®Google Scholar
• Zhao S, Sherwood OD. Induction of labor with RU 486 (mifepristone) in relaxin-deficient rats: antepartum administration of relaxin facilitates delivery and increases pup survival. Am J Obstet Gynecol. 2004; 190(1)229–38
   PubMed Web of Science ®Google Scholar
• Palejwala S, Stein DE, Weiss G, Monia BP, Tortoriello D, Goldsmith LT. Relaxin positively regulates matrix metalloproteinase expression in human lower uterine segment fibroblasts using a tyrosine kinase signaling pathway. Endocrinology. 2001; 142(8)3405–13
   PubMed Web of Science ®Google Scholar
• Unemori EN, Pickford LB, Salles AL, Piercy CE, Grove BH, Erikson ME, et al. Relaxin induces an extracellular matrix-degrading phenotype in human lung fibroblasts in vitro and inhibits lung fibrosis in a murine model in vivo. J Clin Invest. 1996; 98(12)2739–45
   PubMed Web of Science ®Google Scholar
• Jackson SR, Avery NC, Tarlton JF, Eckford SD, Abrams P, Bailey AJ. Changes in metabolism of collagen in genitourinary prolapse. Lancet. 1996; 347(9016)1658–61
   PubMed Web of Science ®Google Scholar
• Chen BH, Wen Y, Li H, Polan ML. Collagen metabolism and turnover in women with stress urinary incontinence and pelvic prolapse. Int Urogynecol J Pelvic Floor Dysfunct. 2002; 13(2)80–7
   PubMed Web of Science ®Google Scholar
• Chen B, Wen Y, Yu X, Polan ML. Elastin metabolism in pelvic tissues: is it modulated by reproductive hormones?. Am J Obstet Gynecol. 2005; 192(5)1605–13
   PubMed Web of Science ®Google Scholar
• Tincello DG, Adams EJ, Richmond DH. Antenatal screening for postpartum urinary incontinence in nulliparous women: a pilot study. Eur J Obstet Gynecol Reprod Biol. 2002; 101(1)70–3
   PubMed Web of Science ®Google Scholar
• Rortveit G, Daltveit AK, Hannestad YS, Hunskaar S. Vaginal delivery parameters and urinary incontinence: the Norwegian EPINCONT study. Am J Obstet Gynecol. 2003; 189(5)1268–74
   PubMed Web of Science ®Google Scholar