Advanced search
Publication Cover
Acta Orthopaedica Scandinavica Volume 72, 2001 - Issue 5
Journal homepage
1,144
Views
149
CrossRef citations to date
0
Altmetric
Research Article

Blood conservation with tranexamic acid in total hip arthroplasty: A randomized, double-blind study in 40 primary operations

Göran Benoni Departments of 1Orthopaedics and 2Diagnostic Radiology, Malmo University Hospital, SE-205 02 Malmo, Sweden E-mail: [email protected]
,
Hans Fredin Departments of 1Orthopaedics and 2Diagnostic Radiology, Malmo University Hospital, SE-205 02 Malmo, Sweden E-mail: [email protected]
,
Richard Knebel Departments of 1Orthopaedics and 2Diagnostic Radiology, Malmo University Hospital, SE-205 02 Malmo, Sweden E-mail: [email protected]
&
Paul Nilsson Departments of 1Orthopaedics and 2Diagnostic Radiology, Malmo University Hospital, SE-205 02 Malmo, Sweden E-mail: [email protected]
Pages 442-448 | Published online: 08 Jul 2009

  • Benoni G, Fredin H. Fibrinolytic inhibition with tranexamic acid reduces blood loss and blood transfusion after knee arthroplasty. J Bone Joint Surg (Br) 1996; 78: 434-40.
  • Benoni G, Carlsson Å, Petersson C, Fredin H. Does tranexamic acid reduce blood loss in knee arthroplasty?. Acta Orthop Scand (Suppl 256) 1994; 65: 101.
  • Benoni G, Björkman S, Fredin H. Application of pharmacokinetic data from healthy volunteers for the prediction of plasma concentrations of tranexamic acid in surgical patients. Clin Drug Invest 1995; 10: 280-7.
  • Benoni G, Lethagen S, Nilsson P, Fredin H. Tranexamic acid, given at the end of the operation, does not reduce postoperative blood loss in hip arthroplasty. Acta Orthop Scand 2000; 71: 250-4.
  • Bergqvist D, Benoni G, Björgell O, Fredin H, Hedlundh U, Nicolas S, et al. Low-molecular-weight heparin (enoxaparin) as prophylaxis against venous thromboemholism after total hip replacement. N Engl J Med 1996; 335: 696-700.
  • Bierbaum B E, Callaghan J J, Galante J O, Rubash H E, Tooms R E, Welch R B. An analysis of blood management in patients having a total hip or knee arthroplasty. J Bone Joint Surg (Am) 1999; 81: 2-10.
  • Dahl O E, Andreassen G, Aspelin T, Müller C, Mathiesen P, Nyhus S, et al. Prolonged thromboprophylaxis following hip replacement surgery-results of a double-blind, prospective, randomised, placebo-controlled study with dalteparin (Fragmin®). Thromb Haemost 1997; 77: 26-31.
  • Dunn C J, Goa K L. Tranexamic acid: a review of its use in surgery and other indications. Drugs 1999; 5: 1005-32.
  • Duquenne P, Lhoest L, Henkes W, De Sart F. Tranexamic acid reduces postoperative blood losses associated with total hip replacement. J Bone Joint Surg (Br) (Suppl II abstr 489) 1999; 81: 233-4.
  • Ekback G, Axelsson K, Ryttberg L, Edlund B, Kjellberg J, Weckstrom J, et al. Tranexamic acid reduces blood loss in total hip replacement surgery. Anesth Analg 2000; 91: 1124-30.
  • Eriksson B I, Hultman E, Martinell S, Eriksson E, Tengborn L, Risberg B. Regional fibrinolysis following total hip replacement. Thromb Res 1991; 62: 441-7.
  • Flordal P-A. Measurement of blood loss in clinical studies. Eur J Anaesthesiol (Suppl 14) 1997; 14: 35-7.
  • Flordal P A, Ljungström K-G, Ekman B, Neander G. Effects of desmopressin on blood loss in hip arthroplasty. Controlled study in 50 patients. Acta Orthop Scand 1992; 63: 381-5.
  • Hedlund P O. Antifibrinolytic therapy with Cyklokapron in connection with prostatectomy. A double-blind study. Scand J Urol Nephrol 1969; 3: 177-82.
  • Hiippala S, Strid E, Wennerstrand M, Arvela V, Mäntylä S, Ylinen J, et al. Tranexamic acid (Cyklokapron) reduces perioperative blood loss associated with total knee arthroplasty. Br J Anaesth 1995; 74: 534-7.
  • Hiippala S T, Strid L J, Wennerstrand M I, Arvela J V, Niemela H M, Mäntylä S, et al. Tranexamic acid radically decreases blood loss and transfusions associated with total knee arthroplasty. Anesth Analg 1997; 84: 839-44.
  • Horrow J C. Hemostatic therapy revisited. Anaesthes Clin North Am 1994; 12: 91-117.
  • Howes J P, Sharma V, Cohen A T. Letter to the Editor. J Bone Joint Surg (Br) 1996; 78: 995-6.
  • Ido K, Neo M, Asada Y, Kondo K, Morita T, Sakamoto T, et al. Reduction of blood loss using tranexamic acid in total knee and hip arthroplasties. Arch Orthop Trauma Surg 2000; 120: 518-20.
  • Jansen A J, Andreica S, Claeys M, D'Haese J, Camu F, Jochmans K. Use of tranexamic acid for an effective blood conservation strategy after total knee arthroplasty. Br J Anaesth 1999; 83: 596-601.
  • Krishnamurti C, Vukelja S, Alving B. Inhibitory effects of lysine analogues on t-PA-induced whole blood clot lysis. Thromb Res 1994; 73: 419-30.
  • Lisander B, Jacobsson S-A, Ivarsson I, Vegfors M, Engdahl O. Giving both Enoxaparin and Dextran increases the need for transfusion in revision hip arthroplasty. Eur J Surg 1996; 162: 861-6.
  • Nelson C L, Fontenot H J. Ten strategies to reduce blood loss in orthopedic surgery. Am J Surg 1995; 170: 64S-8S.
  • Nilsson I M. Clinical pharmacology of aminocaproic and tranexamic acids. J Clin Pathol (R Coll Pathol) (Suppl) 1980; 14: 41-7.
  • Planes A, Vochelle N, Darmon J Y, Fagola M, Bellaud M, Huet Y. Risk of deep-venous thrombosis after hospital discharge in patients having undergone total hip replacement: double-blind randomised comparison of enoxaparin versus placebo. Lancet 1996; 348: 224-8.
  • Risberg B. Fibrinolysis and trauma. In: Fibrinolysis and the central nervous system (Ed. Sawaya R). Hanley & Belfus, Inc., Philadelphia 1990: 149-56.
  • Spence R K. Surgical red blood cell transfusion practice policies. Am J Surg (Suppl) 1995; 170: 3S-15S.
  • Thorsson O, Leander P, Lilja B, Nilsson P, Obrant K J, Westlin N. Comparing ultrasonography, magnetic resonance imaging and scintigraphy in evaluating an experimentally-induced muscular hematoma. Sound J Med Sci Sports 1993; 3: 110-6.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.