Metastatic Cervical Lymph Nodes from Urogenital Tract Carcinoma: A Diagnostic and Therapeutic Challenge

References

• Hendrick JVV. Occult cancer with cervical lymph node metastasis. Conley J, ed. Cancer of the head and neck. Washington D.C.: Butterworths, 1967: 41–55.
   Google Scholar
• Berge T, Toremalm NG. Cervical and mediastinal lymph node metastases as an otorhinolaryngic prob-lem. Ann Otol 1969; 78: 663–70.
   Google Scholar
• Batsakis JG. The pathology of head and neck tumors: the occult primary and metastases to the head and neck, part 10. Head Neck Surg 1981; 3: 409–23.
   PubMedGoogle Scholar
• Hessan H, Strauss M, Sharkey FE. Urogenital tract carcinoma metastatic to the head and neck. Laryngo-scope 1986; 96: 1352–6.
   Google Scholar
• Som PM, Norton KI, Shugar JMA, et al. Metastatic hypernephroma to the head and neck. Am J Neurora-diol 1987; 8: 1103–6.
   PubMedGoogle Scholar
• Issing PR, Stöver T, Kempf HG, Heermann R, Lenarz T. Sonographic diagnosis of metastatic renal cell car-cinoma to the head and neck region. Ultraschall Med 1999; 20: 218–22.
   PubMedGoogle Scholar
• Ellison E, LaPuerta P, Martin SE. Supraclavicular masses: results of a series of 309 cases biopsied by fine needle aspiration. Head Neck 1999; 21: 239–46.
   Google Scholar
• Ferlito A, Boccato P, Shaha AR, et al. The art of diagnosis in head and neck tumors. Acta Otolaryngol 2001; 121: 324–8.
   PubMed Web of Science ®Google Scholar
• McMenamin PG, Anderson JD, Baker JJ. Prostatic carcinoma presenting with neck metastasis. J Otolaryn-gol 1989; 18: 119–24.
   Google Scholar
• Cho KR, Epstein JI. Metastatic prostatic carcinoma to supradiaphragmatic lymph nodes. A clinicopathologic and immunohistochemical study. Am J Surg Pathol 1987; 11: 457–63.
   PubMed Web of Science ®Google Scholar
• Ro JY, El-Naggar A, Ayala AG, Mody DR, Ordonez NG. Signet-ring-cell carcinoma of the prostate. Elec-tron-microscopic and immunohistochemical studies of eight cases. Am J Surg Pathol 1988; 12: 453–60.
   PubMed Web of Science ®Google Scholar
• Fernandez Borrell A, Peinado Ibarra F, Gomez Sancha F, et al. Left supraclavicular adenopathy with a neu-roendocrine pattern of unknown cause: prostatic car-cinoma metastasis. Actas Urol Esp 1999; 23: 603–8.
   PubMedGoogle Scholar
• Keen CE, Szakacs S, Okon E, Rubin JS, Bryant BM. CA125 and thyroglobulin staining in papillary car-cinomas of thyroid and ovarian origin is not com-pletely specific for site of origin. Histopathology 1999; 34: 113–7.
   Google Scholar
• Dal Cin P, Sciot R, De Weyer I, Van Damme B, Van den Berghe H. Diagnosis of primary renal cell car-cinoma in a left supraclavicular lymph node by chro-mosome analysis. J Urol 1996; 156: 171–2.
   Google Scholar
• Steiner G, Sidransky D. Molecular differential diagno-sis of renal carcinoma: from microscopes to microsatel-lites. Am J Pathol 1996; 149: 1791–5.
   PubMed Web of Science ®Google Scholar
• Brown FM. Urine cytology. It is still the gold standard for screening? Urol Clin North Am 2000; 27: 25–37.
   Google Scholar
• Wu WJ, Liu LT, Huang CN, Huang CH, Chang LL. The clinical implications of telomerase activity in upper tract urothelial cancer and washings. Br J Urol Int 2000; 86: 213–9.
   Google Scholar
• Ramakumar S, Bhuiyan J, Besse JA, et al. Comparison of screening methods in the detection of bladder can-cer. J Urol 1999; 161: 388–94.
   PubMed Web of Science ®Google Scholar
• Miller K. Renal cell carcinoma. Guidelines for diagno-sis and treatment Urol Int 1999; 63: 6–9.
   Google Scholar
• Jeong YY, Outwater EK, Kang HK. Imaging evalua-tion of ovarian masses. Radiographics 2000; 20: 1445–70.
   Google Scholar
• Bast RC Jr, Xu FJ, Yu YH, Barnhill S, Zhang Z, Mills GB. CA 125: the past and the future. Int J Biol Markers 1998; 13: 179–87.
   PubMed Web of Science ®Google Scholar
• van der Planken HJ, Tiwari RM, Karim AB. Treat-ment of cervical lymph node metastasis from an un-known primary tumor, with a review of the literature. Strahlenther Onkol 1997; 173: 163–9.
   PubMedGoogle Scholar
• Jakobsen J, Aschenfeldt P, Johansen J, Jorgensen K. Lymph node metastases in the neck from unknown primary tumour. Acta Oncol 1992; 31: 653–5.
   PubMed Web of Science ®Google Scholar
• Boles R, Cerny J. Head and neck metastases from renal cell carcinomas. Mich Med 1971; 70: 616–8.
   PubMedGoogle Scholar
• Giuliani A, Caporale A, Borghese M, Galati G, Di Bari M, Demoro M. Papillary renal cell carcinoma presenting as nodal metastases to the neck. J Exp Clin Cancer Res 1999; 18: 579–82.
   PubMedGoogle Scholar
• Boggess MA, Hester TO, Archer SM. Renal clear cell carcinoma appearing as a left neck mass. Ear Nose Throat J 1996; 75: 620–2.
   Google Scholar
• Kharoubi S. Cervical lymph node metastasis disclosing a Grawitz's tumor. A propos of a case. Ann Urol 1997; 31: 348–51.
   PubMedGoogle Scholar
• Gottlieb MD, Roland JT Jr. Paradoxical spread of renal cell carcinoma to the head and neck. Laryngo-scope 1998; 108: 1301–5.
   PubMedGoogle Scholar
• Vara A, Madrigal B, Perez del Rio MJ, Diaz A, Mateos A, Sales C. Parotid metastasis from renal clear cell adenocarcinoma. An unusual site for metastasis. Urol Int 1998; 61: 196–8.
   Google Scholar
• Matz LR, Latham BI, Fabian VA, Vivian JB. Collect-ing duct carcinoma of the kidney: a report of three cases and review of the literature. Pathology 1997; 29: 354–9.
   PubMed Web of Science ®Google Scholar
• Quivey JM, Fu KK, Herzog KA, Weiss JM, Phillips TL. Malignant tumors of the testis: analysis of treat-ment results and sites and causes of failure. Cancer 1977; 39: 1247–53.
   Google Scholar
• McCauley RL, Javadpour N. Supraclavicular node biopsy in staging of testicular carcinoma. Cancer 1983; 51: 359–61.
   PubMedGoogle Scholar
• Opot EN, Magoha GA. Testicular cancer at Kenyatta National Hospital, Nairobi East Afr Med J 2000; 77: 80–5.
   PubMedGoogle Scholar
• Lynch DF Jr, Richie JP. Supraclavicular node biopsy in staging testis tumors. J Urol 1980; 123: 39–40.
   PubMedGoogle Scholar
• Fowler JE Jr, McLeod DG, Stutzman RE. Critical appraisal of routine supraclavicular lymph node biopsy in staging of testicular tumors. Urology 1979; 4: 230–2.
   Google Scholar
• Adolphs HD, Weissbach L, Distelmaier W. Signifi-cance of supraclavicular lymph node biopsy for stag-ing, therapy and prognosis of testicular tumors. Eur Urol 1980; 6: 339–43.
   Google Scholar
• Wood A, Robson N, Tung K, Mead G. Patterns of supradiaphragmatic metastases in testicular germ cell tumours. Clin Radiol 1996; 51: 273–6.
   PubMedGoogle Scholar
• Stoter G, Sleijfer D, Kaye SB, et al. Prognostic factors in metastatic non-seminomatous germ cell tumours: an interim analysis of the EORTC GU-Group experience. Eur Urol 1993; 23: 202–6.
   PubMedGoogle Scholar
• Zeph RD, Weisberger EC, Einhorn LH, Williams SD, Lingeman RE. Modified neck dissection for metastatic testicular carcinoma. Arch Otolaryngol 1985; 111: 667–72.
   Google Scholar
• Brenner PC, Herr HW, Morse MJ, et al. Simultaneous retroperitoneal, thoracic, and cervical resection of postchemotherapy residual masses in patients with metastatic nonseminomatous germ cell tumors of the testis. J Clin Oncol 1996; 14: 1765–9.
   PubMedGoogle Scholar
• Lee JT, Calcaterra TC. Testicular carcinoma metastatic to the neck. Am J Otolaryngol 1998; 19: 325–9.
   PubMedGoogle Scholar
• Weisberger EC, McBride LC. Modified neck dissection for metastatic nonseminomatous testicular carcinoma. Laryngoscope 1999; 109: 1241–4.
   PubMedGoogle Scholar
• Buttner H, Rosanowski F, Pottek T, Hartmann M. Metastasierung von Keimzell-tumoren in den HNO-Bereich-eine seltene Differentialdiagnose von Lymph-knotenmetastasen bei unbekanntem Primärtumor. Laryngorhinootologie 1996; 75: 616–8.
   PubMedGoogle Scholar
• See WA, Laurenzo JF, Dreicer R, Hoffman HT. Inci-dence and management of testicular carcinoma metastatic to the neck. J Urol 1996; 155: 590–2.
   PubMedGoogle Scholar
• Romero JM, Bori MA, Marigil M, Sanz I, Sanz J. Metastasis cervical de un coriocarcinoma. An Otorri-nolaringol Ibero Am 1998; 25: 131–6.
   PubMedGoogle Scholar
• Bumpus HC. Carcinoma of the prostate: a clinical study of 1,000 cases. Surg Gynecol Obstet 1926; 43: 150–5.
   Google Scholar
• Mintz ER, Smith GG. Autopsy findings in 100 cases of prostatic cancer. N Engl J Med 1934; 211: 479–87.
   Google Scholar
• Arnheim FK. Carcinoma of the prostate: a study of the postmortem finding in 176 cases. J Urol 1948; 60: 599–603.
   PubMedGoogle Scholar
• Franks LM. The spread of prostate cancer. J Pathol Bacteriol 1956; 72: 603–11.
   Google Scholar
• Dick S. Carcinoma of the prostate gland with metas-tases. Surg Clin North Am 1962; 42: 771–7.
   PubMedGoogle Scholar
• Warren MM, Furlow WL. Carcinoma of the prostate presenting as a mass in the neck. JAMA 1970; 213: 620–1.
   PubMedGoogle Scholar
• Butler JJ, Howe CD, Johnson DE. Enlargement of the supraclavicular lymph nodes as the initial sign of pro-static carcinoma. Cancer 1971; 27: 1055–63.
   Google Scholar
• Michaelides DN. Poorly differentiated carcinoma of the prostate presenting as bilateral cervical mass: case report. Mil Med 1979; 144: 326–8.
   PubMedGoogle Scholar
• Huang TY, Yam LT, Li CY. Unusual radiologic fea-tures of metastatic prostatic carcinoma confirmed by immunohistochemical study. Urology 1984; 23: 218–23.
   Google Scholar
• Tell DT, Khoury JC, Taylor HG, Veasey SP. Atypical metastasis from prostate cancer: clinical utility of the immuno-peroxidaR technique for prostate-specific antigen. JAMA 1985; 253: 3574–5.
   PubMedGoogle Scholar
• Saeter G, Fossa SD, Ous S, Blom GP, Kaalhus 0. Carcinoma of the prostate with soft tissue or non-re-gional lymphatic metastases at the time of diagnosis: a review of 47 cases. Br J Urol 1984; 56: 385–90.
   Google Scholar
• Sengelov L, Kamby C, von der Maase H. Pattern of metastases in relation to characteristics of primary tumor and treatment in patients with disseminated urothelial carcinoma. J Urol 1996; 155: 111–4.
   Google Scholar
• Wallmeroth A, Wagner U, Moch H, Gasser TC, Sauter G, Mihatsch MJ. Patterns of metastasis in muscle-inva-sive bladder cancer (pT2-4): An autopsy study on 367 patients. Urol Int 1999; 62: 69–75.
   PubMed Web of Science ®Google Scholar
• Yang XJ, Lecksell K, Epstein JI. Can immunohisto-chemistry enhance the detection of micrometastases in pelvic lymph nodes from patients with high-grade urothelial carcinoma of the bladder? Am J Clin Pathol 1999; 112: 649–53.
   Google Scholar
• Uygur MC, Yaman I, Kutluay L, Altug U, Erol D. The relation between p53 overexpression and lymph node metastases in clinical stage t2 and t3a transitional cell bladder carcinoma. J Exp Clin Cancer Res 1999; 18: 391–5.
   Google Scholar
• Jaeger TM, Weidner N, Chew K, et al. Tumor angio-genesis correlates with lymph node metastases in inva-sive bladder cancer. J Urol 1995; 154: 69–71.
   PubMed Web of Science ®Google Scholar
• Parimoo D, Raghavan D. Progress in the management of metastatic bladder cancer. Cancer Control 2000; 7: 347–56.
   PubMedGoogle Scholar
• Vieweg J, Gschwend JE, Herr HW, Fair WR. The impact of primary stage on survival in patients with lymph node positive bladder cancer. J Urol 1999; 161: 72–6.
   PubMed Web of Science ®Google Scholar
• Aalders JG, Abeler V, Kolstad P. Stage IV endometrial carcinoma: a clinical and histopathological study of 83 patients. Gynecol Oncol 1984; 17: 75–84.
   Google Scholar
• Mallipeddi P, Kapp DS, Teng NN. Long-term survival with adjuvant whole abdominopelvic irradiation for uterine papillary serous carcinoma. Cancer 1993; 71: 3076–81.
   Google Scholar
• Siddiq MA, Bhudia SK, Gana P, Patel PJ. Metastatic endometrial carcinoma of the neck. J Laryngol Otol 2000; 114: 229–30.
   PubMedGoogle Scholar
• Petru E, Pickel H, Tamussino K, et al. Pretherapeutic scalene lymph node biopsy in ovarian cancer. Gynecol Oncol 1991; 43: 262–4.
   PubMedGoogle Scholar
• Patel SV, Spencer JA, Wilkinson N, Perren TJ. Supra-diaphragmatic manifestations of papillary serous ade-nocarcinoma of the ovary. Clin Radiol 1999; 54: 748–54.
   PubMedGoogle Scholar
• Helmkamp BF, Sevin BU, Greening SE, Nadji M, Ng AB, Averette HE. Fine needle aspiration cytology of supraclavicular lymph nodes in gynecologic malignan-cies. Gynecol Oncol 1981; 11: 89–95.
   PubMedGoogle Scholar
• Zang RY, Zhang ZY, Cai SM, Tang MQ, Chen J, Li ZT. Epithelial ovarian cancer presenting initially with extraabdominal or intrahepatic metastases: a prelimi-nary report of 25 cases and literature review. Am J Clin Oncol 2000; 23: 416–9.
   PubMedGoogle Scholar
• Glynne Jones RG, Anand AK, Young TE, Berry RJ. Metastatic adenocarcinoma in the cervical lymph nodes from an occult primary. Clin Oncol (R Coll Radiol) 1989; 1: 19–21.
   PubMedGoogle Scholar
• Spiro RH, DeRose G, Strong EW. Cervical node metastasis of occult origin. Am J Surg 1983; 146: 441–6.
   Google Scholar
• Fried MP, Diehl WH Jr, Brownson RJ, Sessions DG, Ogura JH. Cervical metastasis from an un-known primary. Ann Otol Rhinol Laryngol 1975; 84: 152–7.
   PubMed Web of Science ®Google Scholar
• Croce A, de Vincentiis M, Gallo A, Calcagno P. Le adenopatie latero-cervicali da tumore occulto: espe-rienza clinica e considerazioni sul trattamento terapeu-tico. Acta Otorhinolaryngol Ital 1989; 9: 15–24.
   PubMedGoogle Scholar
• Leipzig B, Winter ML, Hokanson JA. Cervical nodal metastases of unknown origin. Laryngoscope 1981; 91: 593–8.
   Google Scholar
• Redon A, Daly N, Douchez J, Combes PF. Cervical lymph nodes metastasis from an unknown primary: diagnosis, treatment and prognosis. A retrospective study of 127 cases observed from 1959 to 1973. J Radiol 1979; 60: 343–9.
   Google Scholar
• Buckley JG. Monoclonal antibody therapy in treating patients with metastatic kidney cancer. Protocol ID: NCI-98-C-0159, NCI-T98-0035. Personal communica-tion, 2000.
   Google Scholar
• Yu KK, Hawkins RA. The prostate: diagnostic evalua-tion of metastatic disease. Radiol Clin N Am 2000; 38: 139–57.
   PubMed Web of Science ®Google Scholar
• Hillman GG, Triest JA, Cher ML, Kocheril SV, Talati BR. Prospects of immunotherapy for the treatment of prostate carcinoma—a review. Cancer Detect Prey 1999; 23: 333–42.
   PubMedGoogle Scholar