A Novel HPLC-PDA-MS Method for S-Adenosylmethionine and S-Adenosylhomocysteine Routine Analysis

REFERENCES

• Birsan , C. , S. C. Litescu , N. Cucu , and G. L. Radu . 2008 . Determination of S-Adenosylmethionine and S-Adenosylhomocysteine from human blood samples by HPLC-FL . Anal. Lett. 41 : 1720 – 1731 .
   Web of Science ®Google Scholar
• Birsan , C. , S. C. Litescu , I. Vasilescu , S. Eremia , and G. L. Radu . 2006 . Applicability study on some HPLC methods for simultaneous determination of SAM and SAH . Rev. de Chimie. 57 : 790 – 795 .
   Google Scholar
• Brown-Borg , H. M. , S. G. Rakoczy , and E. O. Uthus . 2005 . Growth hormone alters methionine and glutathione . Mech. Aging Dev. 126 : 389 – 398 .
   PubMedGoogle Scholar
• Burren , K. A. , K. Mills , A. J. Copp , and N. D. E. Greene . 2006 . Quantitative analysis of s-adenosylmethionine and s-adenosylhomocysteine in neurulation-stage mouse embryos by liquid chromatography tandem mass spectrometry . J. Chromatogr. B 844 : 112 – 118 .
   PubMedGoogle Scholar
• Castro , R. , E. A. Struys , E. E. W. Jansen , H. J. Blom , I. Tavares de Almeida , and C. Jakobs . 2002 . Quantification of plasma S-adenosylmethionine and S-adenosylhomocysteine as their fluorescent 1,N6-etheno derivatives: An adaptation of previously described methodology . J. Pharm. Biomed. Anal. 29 : 963 – 968 .
   PubMed Web of Science ®Google Scholar
• Chiang , P. K. , R. K. Gordon , J. Tal , G. C. Zeng , B. P. Doctor , K. Pardhasaraadhi , and P. P. McCann . 1996. S-Adenosylmethionine and methylation. FASEBJ. 10: 471–480.
   PubMed Web of Science ®Google Scholar
• Feil , R. 2006 . Environmental and nutritional effects on the epigenetic regulation of genes . Mutat. Res-Fund. Mol. M. 600 : 46 – 57 .
   PubMed Web of Science ®Google Scholar
• Fontecave , M. , M. Atta , and E. Mulliez . 2004 . S-adenosylmethionine: Nothing goes to waste . Trends. Biochem. Sci. 29 : 243 – 249 .
   PubMed Web of Science ®Google Scholar
• Gellekink , H. , D. van Oppenraaij-Emmerzaal , A. Rooij , E. A. Struys , M. den Heijer , and H. J. Blom . 2005 . Stable-isotope dilution liquid chromatography-electrospray injection tandem mass spectrometry method for fast, selective measurement of S-adenosylmethionine and S-adenosylhomocysteine in plasma . Clin. Chem. 51 : 1487 – 1492 .
   PubMed Web of Science ®Google Scholar
• Herbig , K. , E. P. Chiang , L. R. Lee , J. Hills , B. Shane , and P. J. Stover . 2002 . Cytoplasmic serine hydroxymethyltransferase mediates competition between Folate-dependent deoxyribonucleotide and S-Adenosylmethionine biosyntheses . J. Biol. Chem. 277 : 38381 – 38389 .
   PubMed Web of Science ®Google Scholar
• Hitchler , M. J. , and F. E. Domann . 2007 . Domann An epigenetic perspective on the free radical theory of development . Free Radical Bio. Med. 43 : 1023 – 1036 .
   PubMed Web of Science ®Google Scholar
• Kharbanda , K. K. , D. D. Rogers II , M. E. Mailliard , G. L. Siford , A. J. Barak , H. C. Beckenhauer , M. F. Sorrell , and D. J. Tuma . 2005 . Role of elevated S-adenosylhomocysteine in rat hepatocyte apoptosis: Protection by betaine . Biochem. Pharmacol. 70 : 1883 – 1890 .
   PubMed Web of Science ®Google Scholar
• Lin , P. Y. , T. H. Yang , H. G. Lin , and M. L. Hu . 2007 . Synergistic effects of S-adenosylhomocysteine and homocysteine on DNA damage in a murine microglial cell line . Clin. Chim. Acta. 379 : 139 – 144 .
   PubMedGoogle Scholar
• Liu , H. , J. P. Lin , P. L. Cen , and Y. J. Pan . 2004 . Co-production of S-adenosyl-l-methionine and glutathione from spent brewer's yeast cells . Process Biochem. 39 : 1993 – 1997 .
   Web of Science ®Google Scholar
• Loehrer , F. M. T. , M. Tschöpl , C. P. Angst , P. Litynski , K. Jäger , B. Fowler , and W. E. Haefeli . 2001 . Disturbed ratio of erythrocyte and plasma S-adenosylmethionine: S-adenosylhomocysteine in peripheral arterial occlusive disease . Atherosclerosis. 154 : 147 – 154 .
   PubMedGoogle Scholar
• Loehrer , F. M. T. , W. E. Haefeli , C. P. Angst , G. Browne , G. Frick , and B. Fowler . 1996 . Effect of methionine loading on 5-methyltetrahydrofolate, S-adenosylmethionine and S-adenosylhomocysteine in plasma of healthy humans . Clin. Sci (Lond). 91 : 79 – 86 .
   PubMedGoogle Scholar
• Luippold , G. , U. Delabar , D. Kloor , and B. Mühlbauer . 1999 . Simultaneous determination of adenosine, S-adenosylhomocysteine and S-adenosylmethionine in biological samples using solid-phase extraction and high-performance liquid chromatography . J. Chromatogr. B. 724 : 231 – 238 .
   PubMed Web of Science ®Google Scholar
• Melnyk , S. , M. Pogribna , I. P. Pogribny , P. Yi , and S. J. James . 2000 . Measurement of plasma and intracellular S-Adenosylmethionine and S-Adenosylhomocysteine utilizing coulometric electrochemical detection: Alterations with plasma homocysteine and pyridoxal 5′-phosphate concentrations . Clin. Chem. 46 : 265 – 272 .
   PubMed Web of Science ®Google Scholar
• Pols , H. A. P. , N. Yazdanpanah , and J. B. J. van Meurs . 2007 . Homocysteine, the vitamin B complex family and bone . Int.Cong. Series. 1297 : 151 – 157 .
   Google Scholar
• Reguera , R. M. , C. M. Redondo , Y. Pérez-Pertejo , and R. Balaña-Fouce . 2007 . S-Adenosylmethionine in protozoan parasites: Functions, synthesis and regulation . Mol. Biochem. Parasit. 152 : 1 – 10 .
   PubMedGoogle Scholar
• Selley , M. L. 2007 . A metabolic link between S-adenosylhomocysteine and polyunsaturated fatty acid metabolism in Alzheimer's disease . Neurobiol. Aging 28 : 1834 – 1839 .
   PubMedGoogle Scholar
• Song , Z. , Z. Zhou , M. Song , S. Uriarte , T. Chen , I. Deaciuc , and C. J. McClain . 2007 . Alcohol-induced S-adenosylhomocysteine accumulation in the liver sensitizes to TNF hepatotoxicity: Possible involvement of mitochondrial S-adenosylmethionine transport . Biochem. Pharmacol. 74 : 521 – 531 .
   PubMedGoogle Scholar
• Song , Z. , Z. Zhou , T. Chen , D. Hill , J. Kang , S. Barve , and C. McClain . 2003. S-Adenosylmethionine (SAMe) protects against acute alcohol induced hepatotoxicity in mice. J. Nutr. Biochem. 14: 591–597.
   PubMed Web of Science ®Google Scholar
• Stabler , S. P. , and R. H. Allen . 2004 . Quantification of serum and urinary S-Adenosylmethionine and S-Adenosylhomocysteine by stable-isotope-dilution liquid chromatography-mass spectrometry . Clin. Chem. 50 : 365 – 372 .
   PubMedGoogle Scholar
• Struys , E. A. , E. E. W. Jansen , K. de Meer , and C. Jakobs . 2000 . Determination of S-adenosylmethionine and S-adenosylhomocysteine in plasma and cerebrospinal fluid by stable-isotope dilution tandem mass spectrometry . Clin. Chem. 46 : 1650 – 1656 .
   PubMed Web of Science ®Google Scholar
• Szyf , M. 2003 . Targeting DNA methylation in cancer . Aging Res. Rev. 2 : 299 – 328 .
   PubMed Web of Science ®Google Scholar
• Valli , A. , J. J. Carrero , A. R. Qureshi , G. Garibotto , P. Bárány , J. Axelsson , B. Lindholm , P. Stenvinkel , B. Anderstam , and M. E. Suliman . 2008 . Elevated serum levels of S-adenosylhomocysteine, but not homocysteine, are associated with cardiovascular disease in stage 5 chronic kidney disease patients . Clin. Chim. Acta. 395 : 106 – 110 .
   PubMed Web of Science ®Google Scholar
• Wise , C. K. , C. A. Cooney , S. F. Ali , and L. A. Poirier . 1997 . Measuring S-adenosylmethionine in whole blood, red blood cells and cultured cells using a fast preparation method and high-performance liquid chromatography . J. Chromatogr. B 696 : 145 – 152 .
   PubMed Web of Science ®Google Scholar