32
Views
0
CrossRef citations to date
0
Altmetric
Original Articles

Resolution of the Co-eluting Impurity 3,4-Dihydro-3,3-dimethylisoquinoline in Phentermine Base Using HPLC-UV Photodiode Array Detection Followed by Identification via GC-(EI+)-MS

Pages 2375-2395 | Received 02 Dec 1997, Accepted 22 Jun 1998, Published online: 22 Aug 2006

REFERENCES

  • Ryan , T. W. 4/12 1995 . “ Validation of the HPLC Method for the Assay and Purity of Phentermine HCl Bulk Drug Substance ” . In Ganes Chem. Quality Control Research Report no. 0003 4/12 ,
  • Ryan , T. W. 1993 . GC-MS Analysis of Phentermine Samples . Ganes Chem. Int. Com. , 12/13
  • Binder , S. R. , Adams , A. K. , Regalia , M. , Essien , H. and Rosenblum , R. 1991 . Standardization of a Multiwavelength UV Detector for Liquid Chromatography-Base Toxicological Analyses . J. Chromatogr. , 500 ( 1–2 )
  • Ryan , T. W. 1993 . Resolution of the Non-Specific Spectra of Barbiturates by UV-Photodiode Array Detection . J Liq. Chromatog. , 16 ( 1 )
  • Ryan , T. W. 1993 . Resolution of the Non-Specific Spectra of Barbiturates by UV-Photodiode Array Detection, Part II: Effects of Concentration on Spectral Matching Accuracy . J. Liq. Chromatogr. , 16 ( 2 )
  • Ryan , T. W. 1993 . Identification and Quantification of Tricyclic Antidepressants by UV-Photodiode Array Detection with Multicomponent Analysis . J. Liq. Chromatogr. , 16 ( 7 )
  • Ryan , T. W. 1992 . Determination of Mono- or Di-Substitution in Barbituric Acids By UV Photodiode Array . Ganes Chem. Int. Com. , 3/6
  • Jonsson , J. , Kronstrand , R. and Hatanpaa . 1996 . A Convenient Derivitization Method for the Determination of Amphetamine and Related Drugs in Urine . J. Forensic Sci. , 41 ( 1 )
  • Hughes , R. O. , Bronner , W. E. and Smith , M. L. 1991 . J. Anal Toxiccol, “Detection of Amphetamine and Methamphetamine in Urine by Gas Chromatography-Mass Spectrometry following Derivitization with Levo-Menthylchloroformate” . J. Forensic Sci. , 15 ( 5 )
  • Lehrer , M. 1989 . Improved GC-MS Drug Detection with Chemical Ionization Mass Spectrometry and Ion Trap Detection. Proceedings from the Nat. Meeting of the American Assn. of . Clin. Chemi. , 35 ( 6 )
  • Coutts , R. T. , Baker , G. B. and Liu , S. F. 1980 . Studies on Extraction and Derivitization Procedures in the Analysis of Biogenic Amines . J. Forensic Sci. , 23
  • Ryan , T. W. 1994 . Identification of Barbiturates Using High Performance Liquid Chromatography- Particle Beam EI/CI Mass Spectroscopy . J. Liquid Chromatogr. , 17 ( 4 )
  • Federowic , W. F. 1993 . Phentermine Base (PRO 451C) Batches 247–261 . Ganes Chem. Int. Com. , 12/17
  • Federowic , W. F. 1994 . Phentermine Base (PRO 415C) Review . Ganes Chem. Int. Com. , 10/14
  • Ryan , T. W. 1996 . PRO 415-Related Samples . Ganes Chem. Int. Com. , 4/8
  • Fuson , R. C. 1950 . Advance Organic Chemistry , 405 – 406 . New York, NY : John Wiley & Sons, Inc. .
  • Nodar , R. 1996 . Possible Isolation of 280 nm Impurity from Phentermine HCl . Ganes Chem. Int. Com. , 3/25
  • Ryan , T. W. 1998 . HPLC Impurity Profile Analyses of Pharmceutical Substances Using UV-Photodiode Array Detection . Anal. Let. , 31 ( 4 )

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.