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Annals of Tropical Medicine & Parasitology Volume 58, 1964 - Issue 4
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Original Articles

Chemotherapy of Experimental Schistosomiasis Mansoni: Influence of Dimercaptosuccinic Acid on the Toxicity and Antischistosomal Activity of Sodium Antimony Dimercaptosuccinate and other Antimony Compounds in Mice

H. R. Stohler From the Medical Research Department, F. Hoffmann-La Roche and Company Limited, Basle, Switzerland
&
J. R. Frey From the Medical Research Department, F. Hoffmann-La Roche and Company Limited, Basle, Switzerland
Pages 431-438 | Received 20 Aug 1964, Published online: 17 Mar 2016

REFERENCES

  • Awwaad, S., Nagaty, H. F., Elguindy, M., and Rifaat, M. A. (1960). TWSb in Treating Urinary Bilharziasis in Egyptian Children. J. Trop. Med. Hyg., 63, 204.
  • Braun, H. A., Lusky, L. M., and Calvery, H. O. (1946). The efficacy of 2,3-dimercaptopropanol (BAL) in the therapy of poisoning by compounds of antimony, bismuth, chromium, mercury and nickel. J. Pharmacol., 87, suppl., 119.
  • Cannavà, A., and Cugurra, F. (1961). Attività farmacologica generale e proprietà antitossiche degli acidi dimercapto-succinici. I: Acido meso-2-3-dimercapto-succinico (DTS, DMS, RO 1–7977). Arch, int. Pharmacodyn., 131, 283.
  • Eagle, H., Germuth, F. G. jr., Magnuson, H. J., and Fleischman, R. (1947). The protective action of BAL in experimental antimony poisoning. J. Pharmacol., 89, 196.
  • Gammill, J. F., Southam, C. M., and Van Dyke, H. B. (1947). Effect of 2,3-dimercaptopropanol (BAL) on acute poisoning by tervalent and quinquevalent antimonial drugs. Proc. Soc. exp. Biol., N.Y., 64, 13.
  • Gerecke, M., Friedheim, E. A. H., and Brossi, A. (1961). Zur Kenntnis der 2,3-dimercapto-bernsteinsauren. Helv. chim. acta, 44, 955.
  • Jordan, P., and Randall, K. (1961). Drug trials. Rep. E. Afr. Inst. med. Res., 1960–61, 15.
  • Liang, Y., Chu, C. C., Tsen, Y. L., and Ting, K. S. (1957a). [Studies on antibilharzial drugs. VI: The antidotal effects of sodium dimercaptosuccinate and BAL-glucoside against tartar emetic.] (In Chinese; English summary.) Acta physiol. sin., 21, 24.
  • Liang, Y., Chu, C. C., Tsen, Y. L., and Ting, K. S. Shen, M. L., Chen, E. H., and Ting, K. S. (1957b). [Studies on antibilharzial drugs. X: Influences of sodium dimercaptosuccinate on the distribution, excretion and therapeutic activity of tartar emetic in rabbits.] (In Chinese; English summary.) Ibid., 21, 235.
  • Miller, L. C., and Tainter, M. L. (1944). Estimation of the ED50 and its error by means of logarithmic-probit graph paper. Proc. Soc. exp. Biol., N.Y., 57, 261.
  • Standen, O. D. (1953). Experimental schistosomiasis. III: Chemotherapy and mode of drug action. Ann. trop. Med. Parasit., 47, 26.
  • Thompson, R. H. S., and Whittaker, V. P. (1947). Antidotal activity of British anti-lewisite against compounds of antimony, gold and mercury. Biochem. J., 41, 342.

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