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Original Articles

The antimalarial activity of N-benzyl-oxydihydrotriazines

IV. The development of resistance to BRL 6231 (4,6-diamino-1,2-dihydro-2,2-dimethyl-1-(2,4,5-trichloropropyloxy)-1,3,5 triazine hydrochloride) by Plasmodium berghei

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Pages 9-14 | Received 11 Jun 1980, Published online: 11 Mar 2016

REFERENCES

  • Canfield, C. J. & Rozman, R. S. (1974). Clinical testing of new antimalarial compounds. Bulletin of the World Health Organization, 50, 203–212.
  • Knight, D. J. & Peters, W. (1980). The antimalarial activity of N-benzyloxydihydrotriazines. I. The activity of clociguanil (BRL 50216) against rodent malaria, and studies on its mode of action. Annals of Tropical Medicine and Parasitology, 74, 393–404.
  • Knight, D. J. & Williamson, P. (1980). The antimalarial activity of N-benzyloxydihydrotriazines. II. The development of resistance to clociguanil (BRL 50216) and cycloguanil by P. berghei. Annals of Tropical Medicine and Parasitology, 74, 405–413.
  • Knight, D. J., Mamalis, P. & Peters, W. (1982). The antimalarial activity of N-benzyl oxydihydrotriazines. III. The activity of 4,6-diamino-1,2-dihydro-2,2-dimethyl-1-(2,4,5 trichloropropyloxy)-1,3,5-triazine hydrobromide (BRL 51084) and hydrochloride (BRL 6231). Annals of Tropical Medicine and Parasitology, 76, 1–7.
  • Peters, W. (1965a). Drug resistance in Plasmodium berghei, Vincke and Lips, 1948. I. Chloroquine resistance. Experimental Parasitology, 17, 80–89.
  • Peters, W. (1965b). Drug resistance in Plasmodium berghei. Vincke and Lips, 1948. II. Triazine resistance. Experimental Parasitology, 17, 90–96.
  • Ramakrishnan, S. P., Prakash, S., Chowdhury, D. S. & Basu, P. C. (1961). Studies of Plasmodium berghei, Vincke and Lips, 1948. Part XXIX. The size of parasite population and its relation to the selection of a strain resistant to sulphadiazine. Indian Journal of Malariology, 15, 95–106.
  • Richards, H. N. G. (1970). Quoted in Peters, W. (1970) Chemotherapy and Drug Resistance in Malaria, p. 537. London & New York: Academic Press.
  • Who (1973). Chemotherapy of malaria and resistance to antimalarials. World Health Organization Technical Report Series, No. 529, Geneva.

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