In vitro and in vivo susceptibility of Plasmodium falciparum isolates from Liberia to pyrimethamine, cycloguanil and chlorcycloguanil

REFERENCES

• Avery-Jones, S. (1954). Resistance of Plasmodium falciparum and Plasmodium malariae to pyrimethamine (Daraprim) following mass treatment with this drug. A preliminary note. East African Medical Journal, 31, 47–49.
   PubMedGoogle Scholar
• Björkman, A., Brohult, J., Sirleaf, V., Willcox, M. & Bengtsson, E. (1980). Plasmodium falciparum resistance to pyrimethamine and chlorproguanil—host or parasite dependent. Annals of Tropical Medicine and Parasitology, 74, 245–248.
   PubMed Web of Science ®Google Scholar
• Björkman, A., Brohult, J., Willcox, M., Pehrson, P. O., Rombo, L., Hedman, P., Hetland, G., Kollie, E., Hanson, A. P. & Bengtsson, E. (1985). Malaria control by chlorproguanil. I. Clinical effects and susceptibility of Plasmodium falciparum in vivo after seven years of monthly chlorproguanil administration to children in a Liberian village. Annals of Tropical Medicine and Parasitology, 79, 597–601.
   PubMedGoogle Scholar
• Bygbjerg, I., Ravn, P., Rønn, A., Flachs, H. & Hvidberg, E. F. (1987). Human pharmacokinetics of proguanil and its metabolites. Tropical Medicine and Parasitology, 38, 77–80.
   PubMedGoogle Scholar
• Clyde, D. F. (1960). Cross resistance of malaria parasites. Transactions of the Royal Society of Tropical Medicine and Hygiene, 54, 597–598.
   Google Scholar
• Coosemans, M. H., Barutwanayo, M., Onori, E., Otoul, C., Gryseels, B. & Wéry, M. (1987). Double-blind study to assess the efficacy of chlorproguanil given alone or in combination with chloroquine for malaria chemoprophylaxis in an area with Plasmodium falciparum resistance to chloroquine, pyrimethamine and cycloguanil. Transactions of the Royal Society of Tropical Medicine and Hygiene, 81, 151–156.
   PubMed Web of Science ®Google Scholar
• Crowther, A. F. & Levi, A. A. (1953). Proguanil—the isolation of a metabolite with high antimalarial activity. British Journal of Pharmacology, 8, 93–97.
   Web of Science ®Google Scholar
• Curd, F. H. S., Davey, D. G. & Rose, F. L. (1945). Annals of Tropical Medicine and Parasitology, 39, 208–216.
   PubMed Web of Science ®Google Scholar
• Davey, D. G. & Robertson, G. I. (1957). Experiments with antimalarial drugs in man. IV. An experiment to investigate the prophylactic value of proguanil against a strain of Plasmodium falciparum known to be resistant to therapeutic treatment. Transactions of the Royal Society of Tropical Medicine and Hygiene, 51, 463–466.
   PubMedGoogle Scholar
• Dodge, J. S. (1967). Malaria chemoprophylaxis in four schools in Kaduna, Northern Nigeria. West African Medical Journal, 16, 55–58.
   Google Scholar
• Edstein, M. D. & Veenendaal, J. R. (1987). Chlorproguanil and cycloguanil concentrations in human plasma and urine after Lapudrine administration. Transactions of the Royal Society of Tropical Medicine and Hygiene, 81, 136–139.
   PubMed Web of Science ®Google Scholar
• Field, J. W. & Edeson, J. F. B. (1949). Paludrine resistant falciparum malaria. Transactions of the Royal Society of Tropical Medicine and Hygiene, 43, 233–236.
   Web of Science ®Google Scholar
• Greenberg, J. & Bond, H. W. (1956). Further studies on cross-resistance between pyrimethamine and related compounds. American Journal of Tropical Medicine and Hygiene, 5, 14–18.
   PubMed Web of Science ®Google Scholar
• Greenwood, B. M., Greenwood, A. M., Smith, A. W., Mnenon, A., Bradley, A. K., Snow, R. W., Sisay, F. & Bennett, S. (1989). A comparative study of Lapudrine® (chlorproguanil) and Maloprim® (pyrimethamine and dapsone) as chemoprophylactics against malaria in Gambian children. Transactions of the Royal Society of Tropical Medicine and Hygiene, 83, 182–188.
   PubMed Web of Science ®Google Scholar
• Hitchings, G. H. (1952). Daraprim as an antagonist of folic and folinic acids. Transactions of the Royal Society of Tropical Medicine and Hygiene, 46, 467–473.
   PubMed Web of Science ®Google Scholar
• Howells, R. E., Gilles, H. M. & Bent, N. S. (1985). A comparison of the pyrimethamine and cycloguanil sensitivities of the pre-erythrocytic and erythrocytic stages of drug-sensitive and -resistant strains of Plasmodium yoelii. Annals of Tropical Medicine and Parasitology, 79, 247–251.
   PubMed Web of Science ®Google Scholar
• Laing, A. B. G. (1968). Antimalarial effects of sulphormethoxine, diaphenylsulfone and separate combinations of these with pyrimethamine. A review of preliminary investigations carried out in Tanzania. Journal of Tropical Medicine and Hygiene, 71, 27–35.
   PubMed Web of Science ®Google Scholar
• Mcgregor, I. A. & Smith, D. A. (1952). Daraprim in treatment of malaria. A study of its effects in falciparum and quartan infections in West Africa. British Medical Journal, 1, 730–734.
   PubMed Web of Science ®Google Scholar
• Nguyen-Dinh, P., Spencer, H. C., Chemangey-Masaba, S. & Churchill, F. C. (1982). Susceptibility of Plasmodium falciparum to pyrimethamine and sulfadoxine/pyrimethamine in Kisumu, Kenya. Lancet, i, 823–825.
   Google Scholar
• Panton, L. J. & Greenwood, B. M. (1985). In vitro sensitivity of Plasmodium falciparum to chlorcycloguanil in The Gambia. Transactions of the Royal Society of Tropical Medicine and Hygiene, 79, 491–492.
   PubMed Web of Science ®Google Scholar
• Payne, D. & Wernsdorfer, W. H. (1989). Development of a blood culture medium and a standard in vitro microtest for field-testing the response of Plasmodium falciparum to antifolate antimalarials. Bulletin of the World Health Organization, 67, 59–64.
   PubMed Web of Science ®Google Scholar
• Petersen, E. (1987). Comparison of different methods for determining pyrimethamine susceptibility in P. falciparum malaria. Annals of Tropical Medicine and Parasitology, 81, 1–8.
   PubMed Web of Science ®Google Scholar
• Petersen, E., Flachs, H., Høgh, B., Hanson, A. P., Björkman, A., Hvidberg, E. F. (in press). Plasma erythrocyte and urine concentrations of chlorproguanil and two metabolites in man after different doses. Journal of Tropical Medicine and Hygiene.
   Google Scholar
• Petersen, E., Høgh, B., Marbiah, N. T., Perlmann, H., Willcox, M., Dolopaie, E. Björkman, A., Hanson, A. P. & Perlmann, P. (1990). A longitudinal study of Pfl55/RESA antibodies and immunity to malaria infection in adult Liberians. Transactions of the Royal Society of Tropical Medicine and Hygiene, 84, 339–345.
   PubMed Web of Science ®Google Scholar
• Peterson, D. S., Walliker, D. & Wellems, T. E. (1988). Evidence that a point mutation in dihydrofolate reductase-thymidylate synthase confers resistance to pyrimethamine in falciparum malaria. Proceedings of the National Academy of Science U. S.A., 85, 9114–9118.
   Web of Science ®Google Scholar
• Powell, R. D. & Brewer, G. J. (1967). Effects of pyrimethamine, chlorguanide, and primaquine against exoerythrocytic forms of a strain of chloroquine-resistant Plasmodium falciparum from Thailand. American Journal of Tropical Medicine and Hygiene, 16, 693–698.
   PubMed Web of Science ®Google Scholar
• Rieckmann, K. H., Sax, L. H., Campbell, G. H. & Mrema, J. E. (1978). Drug sensitivity of Plasmodium falciparum. An in vitro micro technique. Lancet, i, 22–23.
   Google Scholar
• Robertson, G. I. (1957). Experiments with antimalarial drugs in man III. Experiments with compound 5943. Transactions of the Royal Society of Tropical Medicine and Hygiene, 51, 457–462.
   PubMedGoogle Scholar
• Schapira, A. (1984). Concomitant resistance to pyrimethamine and cycloguanil of chloroquine-resistant falciparum malaria from East Africa: an in vitro study of 12 isolates. Transactions of the Royal Society of Tropical Medicine and Hygiene, 78, 359–362.
   PubMed Web of Science ®Google Scholar
• Tan-Ariya, P., Brockelman, C. R. & Menabandhu, C. (1987). Optimal concentration of p-aminobenzoic acid and folic acid in the in vitro assay of antifolates against Plasmodium falciparum. American journal of Tropical Medicine and Hygiene, 37, 42–48.
   PubMed Web of Science ®Google Scholar
• Watkins, W. M., Brandling-Bennett, A. D., Oloo, A. J., Howells, R. E., gilles, H. M. & Koeck, D. K. (1987a). Inadequacy of chlorproguanil 20 mg per week as chemoprophylaxis for falciparum malaria in Kenya. Lancet, i, 125–128.
   Google Scholar
• Watkins, W. M., Howells, R. E., Brandling-Bennett, A. D. & Koech, D. K. (1987c). In vitro susceptibility of Plasmodium falciparum isolates from jilore, Kenya, to antimalarial drugs. American journal of Tropical Medicine and Hygiene, 37, 445–451.
   PubMed Web of Science ®Google Scholar
• Watkins, W. M., Chulay, J. D., Sixsmith, D. G., Spencer, H. C. & Howells, R. E. (1987b). A preliminary pharmacokinetic study of the antimalarial drugs proguanil and chlorproguanil. Journal of Pharmacy and Pharmacology, 39, 261–265.
   PubMed Web of Science ®Google Scholar
• Watkins, W. M., Sixsmith, D. G. & Chulay, J. D. (1984). The activity of proguanil and its metabolites, cycloguanil and p-chlorophenylbiguanide, against Plasmodium falciparum in vitro. Annals of Tropical Medicine and Parasitology, 78, 273–278.
   PubMed Web of Science ®Google Scholar
• Watkins, W. M., Sixsmith, D. G., Chulay, J. D. & Spencer, H. C. (1985). Antagonism of sulfadoxine and pyrimethamine antimalarial activity in vitro by p-aminobenzoic acid, p-aminobenzoylglutamic acid and folic acid. Molecular and Biochemical Parasitology, 14, 55–61.
   PubMed Web of Science ®Google Scholar
• Weidekamm, E., Plozza-Nottebrock, H., Forgo, I. & Dubach, D. C. (1982). Plasma concentrations of pyrimethamine and sulfadoxine and evaluation of pharmacokinetic data by computerized curve fitting. Bulletin of the World Health Organization, 60, 115–122.
   PubMed Web of Science ®Google Scholar